AKAP1 and PRKAR1B

Number of citations of the paper that reports this interaction (PMID 12634056)
2

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		AKAP1	PRKAR1B
Gene Name		A kinase (PRKA) anchor protein 1	protein kinase, cAMP-dependent, regulatory, type I, beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Integral Component Of Membrane	Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Ciliary Base
	Molecular Function	RNA Binding Protein Binding Poly(A) RNA Binding	CAMP-dependent Protein Kinase Inhibitor Activity CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Blood Coagulation	Renal Water Homeostasis Energy Reserve Metabolic Process Protein Phosphorylation Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Learning Or Memory Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Factors involved in megakaryocyte development and platelet production	Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Integration of energy metabolism Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Downstream signaling of activated FGFR DARPP-32 events Glucagon signaling in metabolic regulation Innate Immune System Signaling by PDGF PKA activation in glucagon signalling Calmodulin induced events Signalling by NGF DAP12 interactions PKA-mediated phosphorylation of CREB PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events PKA activation Factors involved in megakaryocyte development and platelet production Signaling by Overexpressed Wild-Type EGFR in Cancer Aquaporin-mediated transport Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR Downstream signal transduction Calmodulin induced events Signaling by Hedgehog PLC-gamma1 signalling Signaling by EGFR in Cancer PKA activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: AMY1A APP CAV1 MAATS1 MYCBP PPP1CA PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTPN21	8 interactors: AKAP1 EGFR PPP1R9A PRKAR1A SMAD3 SMAD4 WNK1 WRN
Entrez ID		8165	5575
HPRD ID		03905	01485
Ensembl ID		ENSG00000121057	ENSG00000188191
Uniprot IDs		B4DN86 Q92667	P31321
PDB IDs			4DIN 4F9K
Enriched GO Terms of Interacting Partners?		Negative Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of CAMP-dependent Protein Kinase Activity Activation Of Protein Kinase A Activity Renal Water Homeostasis Cellular Response To Glucagon Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity Energy Reserve Metabolic Process Water Transport Fluid Transport Multicellular Organismal Water Homeostasis Activation Of Phospholipase C Activity Response To Glucagon Positive Regulation Of Phospholipase C Activity Blood Coagulation Hemostasis Water Homeostasis Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Body Fluid Levels Wound Healing Renal System Process Negative Regulation Of Transferase Activity Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Protein Phosphorylation Response To Wounding Regulation Of Protein Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Generation Of Precursor Metabolites And Energy Chemical Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Positive Regulation Of Hydrolase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Peptide Hormone Secretion Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus	SMAD Protein Complex Assembly Positive Regulation Of Protein Import Into Nucleus Regulation Of Transforming Growth Factor Beta2 Production Negative Regulation Of Protein Metabolic Process Positive Regulation Of Catenin Import Into Nucleus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Cell Development Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Protein Phosphorylation Mesoderm Development Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Cellular Response To Growth Factor Stimulus Gastrulation Regulation Of Catenin Import Into Nucleus Regulation Of Phosphorylation Response To Growth Factor Regulation Of Protein Localization To Nucleus Regulation Of Protein Transport Tissue Morphogenesis Regulation Of Nucleocytoplasmic Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Regulation Of Protein Localization Multicellular Organismal Development Negative Regulation Of Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Stem Cell Differentiation Activation Of Phospholipase C Activity SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Protein Transport Positive Regulation Of Phospholipase C Activity Neuron Development Regulation Of Cellular Protein Metabolic Process Cell Differentiation Digestive Tract Morphogenesis Response To Stress Response To Stimulus Regulation Of Cellular Localization Positive Regulation Of Hydrolase Activity Developmental Process Regulation Of Protein Catabolic Process Negative Regulation Of Phosphorylation Response To Abiotic Stimulus
Tagcloud ?		2a akaps bad barbier biol chaturvedi competes contributed dephosphorylates depletion dissociation exist p90 patel phosphatases pka pkarialpha poppleton pp2ac redistribution rsk rsk1 rsk2 rsk3 silenced silencing stringfield subcellular unstimulated	ad aimed alzheimer app c9orf72 defect defects dementia dutch early especially expansions find forms frequency ftd genetic grn mapt mutation mutations netherlands none onset pathogenic percent psen1 repeat resp
Tagcloud (Difference) ?		2a akaps bad barbier biol chaturvedi competes contributed dephosphorylates depletion dissociation exist p90 patel phosphatases pka pkarialpha poppleton pp2ac redistribution rsk rsk1 rsk2 rsk3 silenced silencing stringfield subcellular unstimulated	ad aimed alzheimer app c9orf72 defect defects dementia dutch early especially expansions find forms frequency ftd genetic grn mapt mutation mutations netherlands none onset pathogenic percent psen1 repeat resp
Tagcloud (Intersection) ?