AKAP13 and YWHAE

Number of citations of the paper that reports this interaction (PubMedID 15229649)
34

Data Source:
HPRD (in vivo, in vitro)

		AKAP13	YWHAE
Description		A-kinase anchoring protein 13	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cell Cortex Actin Cytoskeleton Membrane Cortical Actin Cytoskeleton	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Membrane Mitochondrial Membrane Melanosome Extracellular Exosome
	Molecular Function	MAP-kinase Scaffold Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding Protein Kinase A Binding Molecular Adaptor Activity	RNA Binding Protein Phosphatase Inhibitor Activity Calcium Channel Regulator Activity Protein Binding Potassium Channel Regulator Activity Calcium Channel Inhibitor Activity Enzyme Binding Protein Phosphatase Binding Protein Domain Specific Binding MHC Class II Protein Complex Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Histone Deacetylase Binding Transmembrane Transporter Binding Cadherin Binding Protein Heterodimerization Activity Phosphoserine Residue Binding Phosphoprotein Binding Scaffold Protein Binding Protein Sequestering Activity Molecular Function Inhibitor Activity
	Biological Process	MAPK Cascade G Protein-coupled Receptor Signaling Pathway Heart Development Regulation Of Rho Protein Signal Transduction Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Cardiac Muscle Cell Differentiation Regulation Of Sarcomere Organization Bone Development Adrenergic Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction	MAPK Cascade Neuron Migration Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Heart Rate By Hormone Protein Targeting Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Signal Transduction Regulation Of Mitotic Cell Cycle Intracellular Protein Localization Substantia Nigra Development Hippocampus Development Cerebral Cortex Development Intracellular Potassium Ion Homeostasis Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Protein Localization To Nucleus Cellular Response To Heat Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Export From Nucleus Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Membrane Repolarization Protein Localization To Endoplasmic Reticulum Protein K11-linked Ubiquitination Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Calcium Ion Export Across Plasma Membrane
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Signaling by Hippo NADE modulates death signalling Regulation of PLK1 Activity at G2/M Transition Regulation of HSF1-mediated heat shock response HSF1 activation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RAB GEFs exchange GTP for GDP on RABs SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Fusicoccin Phenethyl Isothiocyanate
Diseases			Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		A body shape index ( 34021172) Birth weight ( 31043758) Central corneal thickness ( 20719862 32528159 31798171 29760442) Corneal structure ( 23291589) Coronary artery disease ( 29212778) Granulocyte percentage of myeloid white cells ( 27863252) Hemoglobin ( 32888494) High myopia ( 32428537) Idiopathic pulmonary fibrosis ( 31710517 29066090) Immature fraction of reticulocytes ( 32888494) Intraocular pressure ( 29617998) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) Offspring birth weight ( 31043758) Platelet count ( 32888494) Platelet distribution width ( 32888494) Post-bronchodilator lung function in asthma (FEV1/FVC) ( 32989782) Psoriasis ( 25939698) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to platinum-based chemotherapy (carboplatin) ( 21844884) Systolic blood pressure ( 30578418) Waist circumference adjusted for body mass index ( 34021172)	Atrial fibrillation ( 30061737) Bevacizumab-induced composite toxicity (either hypertension or proteinuria) ( 34616010) High light scatter reticulocyte percentage of red cells ( 32888494) Left ventricular mass to end-diastolic volume ratio (MTAG) ( 33495596) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nicotine dependence symptom count ( 25555482) Reaction time ( 29844566) Schizophrenia ( 28991256 30285260)
Interacting Genes		21 interacting genes: APP CTNNAL1 ESR1 ESR2 GNA12 GNAQ LINC00839 MAP1LC3A PPARA PRKAR2A PRKD1 RANBP2 RHOA RTKN RXRB SRPK2 THRA YWHAB YWHAE YWHAG YWHAZ	148 interacting genes: ABL1 ACD AKAP13 AKAP9 ANKHD1-EIF4EBP3 ANKZF1 ARHGEF2 ARHGEF28 ATP6V0B ATXN1 BAD BCR BEX3 CALM1 CAP2 CASK CASP3 CCDC125 CCR9 CDC25A CDC25B CDK11B CDK14 CDK16 CDKN1B CEP131 CEP95 CGNL1 CHAF1A CHST11 CYSLTR2 DDX54 DISC1 DYRK1A ENKD1 EXO1 FAM13B FAM53C FGF12 FHL1 FTH1 GAPDH GPRIN2 GRAP2 GSTA1 GSTM3 GTF2B HDAC4 HDAC5 HIVEP2 HNRNPC HSF1 HSP90AA1 HSPB1 IGF1R IL7R ING1 IRAG2 IRS1 IRS2 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KIAA0232 KIF1C KLC4 KRT18 LCOR LCP2 MAGEB4 MAP3K10 MAP3K2 MAP3K3 MAP3K5 MAPK7 MARK2P21 MCM10 MDM4 METAP2 MSL2 MST1R MT-CO2 MYH10 NAF1 NCAM2 NCOR2 NDEL1 NEDD4L NIN PAPOLA PARD3B PIMREG PNLIP POT1 PRC1 PRDX6 PRKCG RAB11FIP2 RAF1 RAP1GAP2 RASAL3 RASGRF1 RBIS RBM14 REM1 RGS3 RIN1 RIPK2 RPA2 RPGR RXFP3 SAMSN1 SLC8A1 SLC8A2 SLC8A3 SMAGP SNAPIN SNCA SNF8 SORBS2 SRC SYN2 TAF7 TAFAZZIN TBC1D3F TBP TCEANC TFDP2 TGFB1 TLK1 TNFAIP3 TOP2A TSC1 TSC2 TTC3 UBE3A USP43 VIM WNK1 WWTR1 YWHAB YWHAG YWHAH YWHAZ ZC3HC1 ZNF839
Entrez ID		11214	7531
HPRD ID		05253	05457
Ensembl ID		ENSG00000170776	ENSG00000108953
Uniprot IDs		A8MYJ1 B0AZU4 Q12802	P62258 V9HW98
PDB IDs		2DRN 2LG1 4D0N 4D0O 6BCA	2BR9 3UAL 3UBW 6EIH 7C8E 7V9B 8DGM 8DGN 8DGP 8DP5 8Q1S
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Nuclear Receptor Activity Protein Domain Specific Binding Nuclear Steroid Receptor Activity Intracellular Signaling Cassette Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Steroid Hormone Receptor Signaling Pathway Phosphoserine Residue Binding Protein Sequestering Activity Cellular Response To Oxygen-containing Compound Focal Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Rho Protein Signal Transduction Cellular Response To Starvation Negative Regulation Of MiRNA Transcription Regulation Of Cell Communication Regulation Of Signaling Response To Starvation Response To Norepinephrine Cellular Response To Norepinephrine Stimulus Nuclear Estrogen Receptor Activity Cellular Response To Nutrient Levels Regulation Of Nucleocytoplasmic Transport Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Protein Localization To Nucleus Cytosol Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Localization To Nucleus Regulation Of System Process Cellular Response To Amino Acid Starvation Positive Regulation Of Transcription By RNA Polymerase II Response To Amino Acid Starvation Regulation Of Biological Quality Estrogen Response Element Binding G Protein Activity G Protein-coupled Receptor Binding Enzyme Binding Protein Targeting Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Innate Immune Response Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway	Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signaling Identical Protein Binding Regulation Of Signal Transduction Regulation Of Protein Modification Process Regulation Of Biological Quality Transmembrane Transporter Binding Positive Regulation Of Metabolic Process Cytoplasm Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Membrane Potential Cytosol Negative Regulation Of Signal Transduction Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Signal Transduction MAPK Cascade Nucleus Regulation Of Rho Protein Signal Transduction Intracellular Signaling Cassette MAP Kinase Kinase Kinase Activity Regulation Of Catalytic Activity Cellular Response To Hydrogen Peroxide Protein Kinase Binding Axon Postsynaptic Density Calcium:sodium Antiporter Activity Response To Hydrogen Peroxide Protein-containing Complex Protein Kinase C Binding Cellular Response To Chemical Stress Protein Domain Specific Binding Regulation Of Primary Metabolic Process Cellular Response To Reactive Oxygen Species Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Transferase Activity Enzyme Binding Perinuclear Region Of Cytoplasm
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?