AKAP13 and RTKN

Number of citations of the paper that reports this interaction (PubMedID 19696020)
40

Data Source:
BioGRID (pull down)

		AKAP13	RTKN
Description		A-kinase anchoring protein 13	rhotekin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cell Cortex Actin Cytoskeleton Membrane Cortical Actin Cytoskeleton	Actomyosin Contractile Ring Cytosol
	Molecular Function	MAP-kinase Scaffold Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding Protein Kinase A Binding Molecular Adaptor Activity	Nucleotide Binding GTPase Inhibitor Activity Protein Binding GTP Binding Small GTPase Binding
	Biological Process	MAPK Cascade G Protein-coupled Receptor Signaling Pathway Heart Development Regulation Of Rho Protein Signal Transduction Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Cardiac Muscle Cell Differentiation Regulation Of Sarcomere Organization Bone Development Adrenergic Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Apoptotic Process Signal Transduction Rho Protein Signal Transduction Septin Ring Organization Regulation Of Apoptotic Process
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		A body shape index ( 34021172) Birth weight ( 31043758) Central corneal thickness ( 20719862 32528159 31798171 29760442) Corneal structure ( 23291589) Coronary artery disease ( 29212778) Granulocyte percentage of myeloid white cells ( 27863252) Hemoglobin ( 32888494) High myopia ( 32428537) Idiopathic pulmonary fibrosis ( 31710517 29066090) Immature fraction of reticulocytes ( 32888494) Intraocular pressure ( 29617998) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) Offspring birth weight ( 31043758) Platelet count ( 32888494) Platelet distribution width ( 32888494) Post-bronchodilator lung function in asthma (FEV1/FVC) ( 32989782) Psoriasis ( 25939698) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to platinum-based chemotherapy (carboplatin) ( 21844884) Systolic blood pressure ( 30578418) Waist circumference adjusted for body mass index ( 34021172)	Refractive error ( 32231278)
Interacting Genes		21 interacting genes: APP CTNNAL1 ESR1 ESR2 GNA12 GNAQ LINC00839 MAP1LC3A PPARA PRKAR2A PRKD1 RANBP2 RHOA RTKN RXRB SRPK2 THRA YWHAB YWHAE YWHAG YWHAZ	12 interacting genes: AKAP13 APP GOPC MAP1LC3A MFHAS1 RAC2 RHOA RHOB RHOC SMURF1 TAX1BP3 TGFBR1
Entrez ID		11214	6242
HPRD ID		05253	03795
Ensembl ID		ENSG00000170776	ENSG00000114993
Uniprot IDs		A8MYJ1 B0AZU4 Q12802	A0A1W2PPZ2 Q9BST9
PDB IDs		2DRN 2LG1 4D0N 4D0O 6BCA
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Nuclear Receptor Activity Protein Domain Specific Binding Nuclear Steroid Receptor Activity Intracellular Signaling Cassette Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Steroid Hormone Receptor Signaling Pathway Phosphoserine Residue Binding Protein Sequestering Activity Cellular Response To Oxygen-containing Compound Focal Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Rho Protein Signal Transduction Cellular Response To Starvation Negative Regulation Of MiRNA Transcription Regulation Of Cell Communication Regulation Of Signaling Response To Starvation Response To Norepinephrine Cellular Response To Norepinephrine Stimulus Nuclear Estrogen Receptor Activity Cellular Response To Nutrient Levels Regulation Of Nucleocytoplasmic Transport Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Protein Localization To Nucleus Cytosol Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Localization To Nucleus Regulation Of System Process Cellular Response To Amino Acid Starvation Positive Regulation Of Transcription By RNA Polymerase II Response To Amino Acid Starvation Regulation Of Biological Quality Estrogen Response Element Binding G Protein Activity G Protein-coupled Receptor Binding Enzyme Binding Protein Targeting Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Innate Immune Response Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway	Intracellular Signal Transduction Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Skeletal Muscle Satellite Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Signal Transduction Regulation Of Actin Cytoskeleton Organization GTP Binding Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Stress Fiber Assembly Cleavage Furrow Negative Regulation Of Protein Localization Supramolecular Fiber Organization Rho Protein Signal Transduction Positive Regulation Of Lipase Activity Positive Regulation Of Actin Filament Bundle Assembly Mitotic Cytokinesis Apical Junction Assembly Regulation Of Cytoskeleton Organization Regulation Of Cell Migration Actin Filament Organization Endothelial Tube Morphogenesis Negative Regulation Of Protein Localization To Cell Surface Regulation Of Cell Motility Cytoskeleton-dependent Cytokinesis Regulation Of Stress Fiber Assembly Regulation Of Locomotion Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of Modification Of Postsynaptic Structure GTPase Activity I-SMAD Binding Regulation Of Cell Projection Organization Response To Lead Ion Regulation Of Modification Of Synaptic Structure Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Copper Ion Positive Regulation Of Leukocyte Migration Regulation Of Intracellular Signal Transduction Extracellular Exosome Negative Regulation Of Signal Transduction Wound Healing, Spreading Of Cells Regulation Of Signal Transduction Regulation Of Protein Localization
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