ARFGEF2 and GABRB3

Number of citations of the paper that reports this interaction (PubMedID 15198677)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ARFGEF2	GABRB3
Description		ARF guanine nucleotide exchange factor 2	gamma-aminobutyric acid type A receptor subunit beta3
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Axonemal Microtubule Membrane Dendrite Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Cell Projection Dendritic Spine Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse	Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Chloride Channel Complex Dendritic Spine Synapse Postsynaptic Membrane GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding GABA Receptor Binding	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity GABA-gated Chloride Ion Channel Activity Identical Protein Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Receptor Recycling Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Endomembrane System Organization Protein Transport Vesicle-mediated Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction	Monoatomic Ion Transport Chloride Transport Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Nervous System Development Brain Development Learning Memory Response To Xenobiotic Stimulus Reproductive Behavior Cerebellum Development Monoatomic Ion Transmembrane Transport Social Behavior Exploration Behavior Circadian Sleep/wake Cycle, REM Sleep Neuron Development Synaptic Transmission, GABAergic Roof Of Mouth Development Hard Palate Development Inhibitory Postsynaptic Potential Inner Ear Receptor Cell Development Innervation Motor Behavior Cellular Response To Zinc Ion Cellular Response To Histamine Response To Anesthetic Cochlea Development Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		Association of TriC/CCT with target proteins during biosynthesis	Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs			Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Lindane Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Piperazine Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Glutethimide Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Fospropofol Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Muscimol 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases		Periventricular nodular heterotopia (PVNH)
GWAS		Adult body size ( 32376654) Anger ( 24489884) Birth weight ( 31043758) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Offspring birth weight ( 31043758) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172)	Body mass index ( 28892062) Cognitive performance ( 19734545) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Longevity ( 20834067) Pericalcarine cortex volume ( 31530798) Postprandial triglyceride response ( 32603185) Refractive error ( 32231278) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Thyroglobulin plasma levels ( 30929638)
Interacting Genes		10 interacting genes: ARFGEF1 EXOC7 GABRB1 GABRB2 GABRB3 LCOR PNPLA2 PRKAR1A PRKAR2A PRPF40A	8 interacting genes: AKAP5 ARFGEF2 MEOX2 PPP2CA PRKACA PRKCA RACK1 UBQLN1
Entrez ID		10564	2562
HPRD ID		09250	08844
Ensembl ID		ENSG00000124198	ENSG00000166206
Uniprot IDs		A0A7P0T7Z2 Q59FR3 Q86TH5 Q9Y6D5	B2RCW8 P28472 X5DQY4
PDB IDs		3L8N 3SWV	4COF 5O8F 5OJM 6A96 6HUG 6HUJ 6HUK 6HUO 6HUP 6I53 6QFA 7PBD 7PBZ 7PC0 7QN5 7QN6 7QN7 7QN8 7QN9 7QNA 7QNB 7QNC 7QND 7QNE 8PVB 9CSB 9CTJ 9CX7 9CXA 9CXC 9EQG
Enriched GO Terms of Interacting Partners?		Cellular Response To Histamine Response To Histamine GABA-A Receptor Activity GABA-gated Chloride Ion Channel Activity GABA-A Receptor Complex Gamma-aminobutyric Acid Signaling Pathway Postsynaptic Specialization Membrane Synaptic Transmission, GABAergic Extracellular Ligand-gated Monoatomic Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Chloride Channel Complex CAMP-dependent Protein Kinase Regulator Activity Chloride Channel Activity CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Nucleotide-activated Protein Kinase Complex Inner Ear Receptor Cell Development Chloride Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Protein Kinase A Catalytic Subunit Binding GABA-ergic Synapse Chloride Transport Inorganic Anion Transmembrane Transport Regulation Of Biological Quality Innervation CAMP Binding Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Inhibitory Synapse Assembly Negative Regulation Of CAMP/PKA Signal Transduction Monoatomic Ion Channel Activity Neuron Development Cochlea Development Plasma Membrane Raft Membrane Ciliary Base Transmembrane Signaling Receptor Activity Regulation Of CAMP/PKA Signal Transduction Postsynaptic Membrane Transmembrane Transport Circadian Sleep/wake Cycle, REM Sleep Prostaglandin-I Synthase Activity Inorganic Ion Transmembrane Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Trans-synaptic Signaling Synaptic Signaling Regulation Of Cytokinesis	GABA Receptor Binding Protein Kinase A Regulatory Subunit Binding Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Transport Perinuclear Region Of Cytoplasm Protein Serine/threonine Phosphatase Complex Positive Regulation Of Establishment Of Protein Localization Vascular Endothelial Cell Response To Fluid Shear Stress Regulation Of Signal Transduction Negative Regulation Of Glycolytic Process Regulation Of Calcium Ion Transmembrane Transport Regulation Of Protein Transport Positive Regulation Of Protein Localization Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of ATP Metabolic Process Regulation Of Establishment Of Protein Localization Regulation Of Vesicle-mediated Transport Regulation Of Cell Communication Regulation Of Signaling Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Fluid Shear Stress Regulation Of Calcium Ion Transport Negative Regulation Of Smoothened Signaling Pathway Response To Fluid Shear Stress Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Glycolytic Process Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Calcium-mediated Signaling Regulation Of Transport Positive Regulation Of Transport Cellular Response To Glucose Stimulus Regulation Of Carbohydrate Catabolic Process RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Regulation Of Protein Localization Regulation Of Metal Ion Transport Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of ATP Metabolic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Signal Transduction Cellular Response To Carbohydrate Stimulus Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Purine Nucleotide Metabolic Process
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