ARFGEF2 and GABRB2

Number of citations of the paper that reports this interaction (PubMedID 15198677)
0

Data Source:
HPRD (two hybrid)

		ARFGEF2	GABRB2
Description		ARF guanine nucleotide exchange factor 2	gamma-aminobutyric acid type A receptor subunit beta2
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Axonemal Microtubule Membrane Dendrite Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Cell Projection Dendritic Spine Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse	Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Chloride Channel Complex Dendritic Spine Synapse Postsynaptic Membrane Extracellular Exosome GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding GABA Receptor Binding	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity GABA Receptor Activity GABA-gated Chloride Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Receptor Recycling Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Endomembrane System Organization Protein Transport Vesicle-mediated Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Neuron Development Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Inner Ear Receptor Cell Development Innervation Cellular Response To Histamine Cochlea Development Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		Association of TriC/CCT with target proteins during biosynthesis	Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs			Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Carisoprodol Eszopiclone Alprazolam Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Ginkgo biloba Glutethimide Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Fospropofol Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases		Periventricular nodular heterotopia (PVNH)
GWAS		Adult body size ( 32376654) Anger ( 24489884) Birth weight ( 31043758) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Offspring birth weight ( 31043758) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172)	Multisite chronic pain ( 31194737 33830993) Nicotine dependence symptom count ( 25555482) Perceived intensity of sweet substances ( 31005972) Plasma neurofilament light levels ( 29747637) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)
Interacting Genes		10 interacting genes: ARFGEF1 EXOC7 GABRB1 GABRB2 GABRB3 LCOR PNPLA2 PRKAR1A PRKAR2A PRPF40A	5 interacting genes: ARFGEF2 PPP3CA PRKCB TRAK2 UBQLN1
Entrez ID		10564	2561
HPRD ID		09250	02578
Ensembl ID		ENSG00000124198	ENSG00000145864
Uniprot IDs		A0A7P0T7Z2 Q59FR3 Q86TH5 Q9Y6D5	P47870
PDB IDs		3L8N 3SWV	6D6T 6D6U 6X3S 6X3T 6X3U 6X3V 6X3W 6X3X 6X3Z 6X40 7T0W 7T0Z 8DD2 8DD3 8SGO 8SI9 8SID 8VQY 8VRN 9CRS 9CRV 9CSB 9CT0 9CTJ 9CTP 9CTV 9CXA 9CXB 9CXC 9CXD 9DRX
Enriched GO Terms of Interacting Partners?		Cellular Response To Histamine Response To Histamine GABA-A Receptor Activity GABA-gated Chloride Ion Channel Activity GABA-A Receptor Complex Gamma-aminobutyric Acid Signaling Pathway Postsynaptic Specialization Membrane Synaptic Transmission, GABAergic Extracellular Ligand-gated Monoatomic Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Chloride Channel Complex CAMP-dependent Protein Kinase Regulator Activity Chloride Channel Activity CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Nucleotide-activated Protein Kinase Complex Inner Ear Receptor Cell Development Chloride Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Protein Kinase A Catalytic Subunit Binding GABA-ergic Synapse Chloride Transport Inorganic Anion Transmembrane Transport Regulation Of Biological Quality Innervation CAMP Binding Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Inhibitory Synapse Assembly Negative Regulation Of CAMP/PKA Signal Transduction Monoatomic Ion Channel Activity Neuron Development Cochlea Development Plasma Membrane Raft Membrane Ciliary Base Transmembrane Signaling Receptor Activity Regulation Of CAMP/PKA Signal Transduction Postsynaptic Membrane Transmembrane Transport Circadian Sleep/wake Cycle, REM Sleep Prostaglandin-I Synthase Activity Inorganic Ion Transmembrane Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Trans-synaptic Signaling Synaptic Signaling Regulation Of Cytokinesis	Negative Regulation Of Transmembrane Transport GABA Receptor Binding Myosin Binding Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Calcium Ion Transport Dendrite Morphogenesis Regulation Of Synaptic Vesicle Exocytosis Establishment Of Protein Localization Negative Regulation Of Transport Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Neurotransmitter Secretion Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Monoatomic Ion Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Regulated Secretory Pathway Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Saliva Secretion Negative Regulation Of Nervous System Development Peptidyl-serine Dephosphorylation Dendritic Spine Regulation Of Intracellular Signal Transduction Negative Regulation Of Neurogenesis Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Histone H3T6 Kinase Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Dendritic Transport Of Mitochondrion Regulation Of Anatomical Structure Morphogenesis Regulation Of Exocytosis Negative Regulation Of Cell Projection Organization Protein Kinase C Signaling Symmetric Synapse Endomembrane System Organization Cytoplasmic Vesicle Positive Regulation Of Synaptic Vesicle Exocytosis Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Glomerulus Development Calmodulin-dependent Protein Phosphatase Activity Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Macromolecule Metabolic Process Regulation Of Calcium Ion Transport Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Transition Between Fast And Slow Fiber Calcium Ion Transport Cell Projection Morphogenesis Positive Regulation Of Kidney Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?