ARFGEF2 and GABRB1

Number of citations of the paper that reports this interaction (PMID 15198677)
28

Data Source:
HPRD (two hybrid)

		ARFGEF2	GABRB1
Gene Name		ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	gamma-aminobutyric acid (GABA) A receptor, beta 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Trans-Golgi Network Microtubule Organizing Center Cytosol Axonemal Microtubule Membrane Cytoplasmic Membrane-bounded Vesicle Cell Junction Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Dendritic Spine Perinuclear Region Of Cytoplasm Recycling Endosome	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Chloride Channel Complex Postsynaptic Membrane GABA-A Receptor Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding GABA Receptor Binding	GABA-A Receptor Activity Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity Ligand-gated Ion Channel Activity
	Biological Process	Receptor Recycling Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Endomembrane System Organization Protein Transport Vesicle-mediated Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Positive Regulation Of GTPase Activity	Transport Ion Transport Signal Transduction Synaptic Transmission Ion Transmembrane Transport Transmembrane Transport Cellular Response To Histamine Chloride Transmembrane Transport
Pathways		Protein folding Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis	GABA receptor activation Ion channel transport GABA A receptor activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Orphan transporters Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		9 interactors: ARFGEF1 EXOC7 GABRB1 GABRB2 GABRB3 PNPLA2 PRKAR1A PRKAR2A PRPF40A	7 interactors: AKAP5 ARFGEF2 C1QBP NEUROD4 NOD1 PIK3CA UBQLN1
Entrez ID		10564	2560
HPRD ID		09250	15924
Ensembl ID		ENSG00000124198	ENSG00000163288
Uniprot IDs		Q59FR3 Q86TH5 Q9Y6D5	P18505
PDB IDs		3L8N 3SWV
Enriched GO Terms of Interacting Partners?		Cellular Response To Histamine Response To Histamine Cellular Response To Ammonium Ion Cellular Response To Organonitrogen Compound Negative Regulation Of CAMP-dependent Protein Kinase Activity Response To Ammonium Ion Response To Organonitrogen Compound Chloride Transmembrane Transport Regulation Of CAMP-dependent Protein Kinase Activity Activation Of Protein Kinase A Activity Chloride Transport Renal Water Homeostasis Innervation Cellular Response To Glucagon Stimulus Inner Ear Receptor Cell Development Inorganic Anion Transport Water Transport Fluid Transport Cochlea Development Activation Of Phospholipase C Activity Multicellular Organismal Water Homeostasis Response To Glucagon Positive Regulation Of Phospholipase C Activity Transmembrane Transport Inner Ear Receptor Cell Differentiation Water Homeostasis Mechanoreceptor Differentiation Cellular Response To Organic Substance Cellular Response To Organic Cyclic Compound Positive Regulation Of Phospholipase Activity Anion Transmembrane Transport Positive Regulation Of Protein Glycosylation In Golgi Transport Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Nerve Development Renal System Process Synaptic Transmission Negative Regulation Of Protein Serine/threonine Kinase Activity Response To Organic Substance Energy Reserve Metabolic Process Positive Regulation Of Protein Glycosylation Sensory Perception Of Sound Anion Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Acylglycerol Acyl-chain Remodeling Negative Regulation Of Neuron Apoptotic Process Sensory Perception Of Mechanical Stimulus	Regulation Of Intracellular Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Stimulus Interleukin-8 Biosynthetic Process Regulation Of Metabolic Process Regulation Of Tumor Necrosis Factor Production Regulation Of Signal Transduction Regulation Of Cytokine Production Regulation Of Apoptotic Process Regulation Of Cell Death Hypomethylation Of CpG Island Positive Regulation Of Trophoblast Cell Migration Negative Regulation Of MDA-5 Signaling Pathway Response To Stimulus Positive Regulation Of Immune Response Regulation Of Signaling Signal Transduction Phosphatidylinositol-mediated Signaling Positive Regulation Of Metabolic Process Signaling Intracellular Signal Transduction Interleukin-8 Production Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Cell Communication Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Cellular Protein Metabolic Process Amacrine Cell Differentiation Positive Regulation Of Protein Kinase A Signaling Regulation Of Immune Response Positive Regulation Of Mitochondrial Translation Regulation Of Genetic Imprinting Positive Regulation Of Immune System Process Positive Regulation Of Dendritic Cell Chemotaxis Regulation Of Protein Metabolic Process Mature Ribosome Assembly Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of RIG-I Signaling Pathway Regulation Of Mitochondrial Translation Negative Regulation Of Viral-induced Cytoplasmic Pattern Recognition Receptor Signaling Pathway Receptor Recycling Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of RIG-I Signaling Pathway Positive Regulation Of Signal Transduction Negative Regulation Of Anoikis Positive Regulation Of Cytokine Production Blood Coagulation, Intrinsic Pathway
Tagcloud ?		13q33 15q26 20q13 22q11 already c20orf199 candidate chromosomes copy cse1l ddx27 deficiency duplications gh hemizygous homozygous individuals integrin investigations itgbl1 kcnb1 mb oligonucleotide predispose ptgis remaining snord12 unreported znfx1	atp5d bear behaviors build cessation chronically clustering diethylamide drd2 hyperactivity illnesses krox20 lsd lysergic medial mpfc ndufa1 neurogenetic neuropeptide neurotransmission npy persist prefrontal qpcr schizophrenia seq sucrose underlie validate
Tagcloud (Difference) ?		13q33 15q26 20q13 22q11 already c20orf199 candidate chromosomes copy cse1l ddx27 deficiency duplications gh hemizygous homozygous individuals integrin investigations itgbl1 kcnb1 mb oligonucleotide predispose ptgis remaining snord12 unreported znfx1	atp5d bear behaviors build cessation chronically clustering diethylamide drd2 hyperactivity illnesses krox20 lsd lysergic medial mpfc ndufa1 neurogenetic neuropeptide neurotransmission npy persist prefrontal qpcr schizophrenia seq sucrose underlie validate
Tagcloud (Intersection) ?