CCAR1 and CASP10

Number of citations: 27 (PubMedID 15069192)
Data Source: HPRD (in vitro)

		CCAR1	CASP10
Name		cell division cycle and apoptosis regulator 1	caspase 10
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Lumen Nucleoplasm Cytoplasm Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Binding Ubiquitin Protein Ligase Activity	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Death Effector Domain Binding
	Biological Process	Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Positive Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Protein Maturation Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis
Pathways		mRNA Splicing - Major Pathway	TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Diseases		None	Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Cannabis dependence symptom count ( 27028160 )	Alanine aminotransferase levels ( 33547301 ) Basal cell carcinoma ( 25855136 ) Chronic lymphocytic leukemia ( 23770605 28165464 ) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831 ) Mean corpuscular hemoglobin ( 32888494 )
Novel Interactors		1 novel interactors: DAO	6 novel interactors: BMPR2 ERBB4 IGFBP2 NPTX1 SCARB1 YBX3
Interacting Genes		18 interacting genes: CASP10 CHERP CTNNB1 DNAAF6 GOLGA2 HMGB1 HNRNPK HUNK MDM2 MIR106B MIRLET7G MTUS2 RBM10 RNF10 RNF113A SFN U2AF2 USP7	30 interacting genes: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP
Entrez ID		55749	843
HPRD ID		10811	03458
Ensembl ID		ENSG00000060339	ENSG00000003400
Uniprot IDs		Q8IX12	A0A0S2Z3G5 A0A0S2Z3Z5 Q92851
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Negative Regulation Of Gene Expression Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Glycoprotein Biosynthetic Process Regulation Of Intracellular Transport Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Protein Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Nucleocytoplasmic Transport Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Vasculature Development Disordered Domain Specific Binding Cadherin Binding Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Protein Ubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Cell Population Proliferation Protein Modification By Small Protein Conjugation Epithelial Cell Proliferation Glial Cell Fate Determination Regulation Of Protein Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Gliogenesis Positive Regulation Of Angiogenesis Regulation Of Myelination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Vasculature Development D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process Regulation Of Protein Export From Nucleus Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Negative Regulation Of Gene Expression, Epigenetic	Cell Death Programmed Cell Death Apoptotic Process Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cysteine-type Peptidase Activity Death Receptor Binding Extrinsic Apoptotic Signaling Pathway Protein Processing Pyroptotic Inflammatory Response Death-inducing Signaling Complex Regulation Of Canonical NF-kappaB Signal Transduction Execution Phase Of Apoptosis Regulation Of Neuron Apoptotic Process Neuron Apoptotic Process Regulation Of Necroptotic Process Cellular Response To Mechanical Stimulus Protein Maturation Regulation Of Programmed Necrotic Cell Death Cell Surface Receptor Signaling Pathway Peptidase Activity Cellular Response To Staurosporine Proteolysis Epithelial Cell Apoptotic Process Regulation Of Signal Transduction Glial Cell Apoptotic Process Positive Regulation Of Execution Phase Of Apoptosis Response To Mechanical Stimulus Response To Anesthetic Ripoptosome CD95 Death-inducing Signaling Complex Response To Lipopolysaccharide Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Defense Response Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Response To Stress Regulation Of Defense Response Regulation Of Intracellular Signal Transduction Response To Cobalt Ion Regulation Of Apoptotic Signaling Pathway Fibroblast Apoptotic Process