CCAR1 and CASP10

Number of citations of the paper that reports this interaction (PMID 15069192)
17

Data Source:
HPRD (in vitro)

		CCAR1	CASP10
Gene Name		cell division cycle and apoptosis regulator 1	caspase 10, apoptosis-related cysteine peptidase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Plasma Membrane CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Poly(A) RNA Binding	Cysteine-type Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding Death Effector Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
	Biological Process	MRNA Splicing, Via Spliceosome Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Cell Cycle RNA Splicing Gene Expression	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Apoptotic Signaling Pathway
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAIL signaling Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Extrinsic Pathway Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: CASP10 CHERP GOLGA2 HNRNPK MDM2 PIH1D3 RBM10 RNF113A SFN U2AF2	30 interactors: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP
Entrez ID		55749	843
HPRD ID		10811	03458
Ensembl ID		ENSG00000060339	ENSG00000003400
Uniprot IDs		Q8IX12	Q92851
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Intracellular Protein Transport RNA Processing Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Export From Nucleus Positive Regulation Of Intracellular Transport Positive Regulation Of Transport Regulation Of Intracellular Protein Transport Positive Regulation Of Protein Transport RNA Splicing Cellular Response To UV-C Cellular Response To Vitamin B1 MRNA Processing Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Intracellular Transport Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter MRNA Metabolic Process Regulation Of Epidermal Cell Division Regulation Of Protein Transport Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Establishment Of Protein Localization Response To Vitamin B1 Response To Ether Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Localization Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of NFAT Protein Import Into Nucleus Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor Biosynthetic Process Response To UV-C Keratinocyte Development Negative Regulation Of Endopeptidase Activity Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Peptidase Activity Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Programmed Cell Death Regulation Of Cellular Localization Axonemal Dynein Complex Assembly Cell Death Death Regulation Of Receptor Biosynthetic Process Establishment Of Skin Barrier	Apoptotic Process Programmed Cell Death Cell Death Death Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Execution Phase Of Apoptosis Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Protein Processing Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Peptidase Activity Regulation Of Cell Death Regulation Of Endopeptidase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Peptidase Activity Positive Regulation Of Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Proteolysis Glial Cell Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To Mechanical Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Mechanical Stimulus Positive Regulation Of Macrophage Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Communication Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Neuron Apoptotic Process Intracellular Signal Transduction Proteolysis Regulation Of Necroptotic Process Positive Regulation Of Neuron Apoptotic Process Neuron Death Regulation Of Cellular Protein Metabolic Process Hepatocyte Apoptotic Process Signaling Positive Regulation Of Neuron Death
Tagcloud ?		alleles architecture cdkn1b chd1 copy damaging drivers encompassing exome foxa1 genotyping heterozygosity interpret interpretation kip1 loh manage mosaicism mutational personalized rb1 retained scpc somatic suppressors tp53 underscores virchow widespread	arginine bcl3 dap1 derepression epigenetic epigenetically governs hdac1 hodgkin hoxa5 hrk indirectly lymphoma master methyltransferase offer p52 polycomb prc2 prmt5 rb1 rbl2 reactivation repression repressor retinoblastoma tp53k372 trigger turn
Tagcloud (Difference) ?		alleles architecture cdkn1b chd1 copy damaging drivers encompassing exome foxa1 genotyping heterozygosity interpret interpretation kip1 loh manage mosaicism mutational personalized retained scpc somatic suppressors tp53 underscores virchow widespread	arginine bcl3 dap1 derepression epigenetic epigenetically governs hdac1 hodgkin hoxa5 hrk indirectly lymphoma master methyltransferase offer p52 polycomb prc2 prmt5 rbl2 reactivation repression repressor retinoblastoma tp53k372 trigger turn
Tagcloud (Intersection) ?		rb1