CCAR1 and RBM10

Number of citations: 106 (PubMedID 35271311)
Data Source: BioGRID (affinity chromatography technology, two hybrid, two hybrid)

		CCAR1	RBM10
Name		cell division cycle and apoptosis regulator 1	RNA binding motif protein 10
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Lumen Nucleoplasm Cytoplasm Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Nucleolus Nuclear Speck Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Binding Ubiquitin Protein Ligase Activity	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding MiRNA Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Positive Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome MRNA Processing Negative Regulation Of Cell Population Proliferation RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome 3'-UTR-mediated MRNA Stabilization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Vascular Associated Smooth Muscle Cell Apoptotic Process Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Ribosomal Large Subunit Export From Nucleus
Pathways		mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Diseases		None	TARP syndrome
GWAS		Cannabis dependence symptom count ( 27028160 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: DAO	1 novel interactors: ATE1
Interacting Genes		18 interacting genes: CASP10 CHERP CTNNB1 DNAAF6 GOLGA2 HMGB1 HNRNPK HUNK MDM2 MIR106B MIRLET7G MTUS2 RBM10 RNF10 RNF113A SFN U2AF2 USP7	73 interacting genes: AKAP9 ATN1 BAHD1 BEND7 CASK CBLL1 CCAR1 CEP70 CPSF7 CSNK2A1 DDX17 DDX5 FAM124A GTSE1 HNRNPH2 HNRNPK HNRNPLL IK KHDRBS2 KLF1 MAPRE2 MBD6 MDM2 MEOX2 MIR106B MIR107 MIR128-1 MIR21 MIR214 MIRLET7A1 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7G MIRLET7I NDEL1 NIN PATZ1 PCBP1 PRC1 PRCC PRDM14 PRR20A PTBP1 PTBP2 RBM12 RBM12B RBM14 RBM4 RBM7 RBMY1F RNF10 SF1 SF3A1 SF3B2 SF3B4 SLAIN1 SNRPA SNU13 SREK1 SRSF6 TBC1D22B THAP1 TLE5 U2AF1 UBQLN4 ZBTB24 ZFP64 ZNF275 ZNF317 ZNF408 ZNF473 ZNF526
Entrez ID		55749	8241
HPRD ID		10811	02095
Ensembl ID		ENSG00000060339	ENSG00000182872
Uniprot IDs		Q8IX12	A0A0S2Z4W4 A0A0S2Z4X1 P98175
PDB IDs		Not available	2LXI 2M2B 2MXV 2MXW 5ZSW 5ZSY
GO Terms Enriched among Interactors		Negative Regulation Of Gene Expression Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Glycoprotein Biosynthetic Process Regulation Of Intracellular Transport Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Protein Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Nucleocytoplasmic Transport Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Vasculature Development Disordered Domain Specific Binding Cadherin Binding Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Protein Ubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Cell Population Proliferation Protein Modification By Small Protein Conjugation Epithelial Cell Proliferation Glial Cell Fate Determination Regulation Of Protein Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Gliogenesis Positive Regulation Of Angiogenesis Regulation Of Myelination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Vasculature Development D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process Regulation Of Protein Export From Nucleus Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Negative Regulation Of Gene Expression, Epigenetic	MRNA Processing MRNA Metabolic Process Regulation Of RNA Splicing Nucleic Acid Binding RNA Splicing Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RNA Processing Post-transcriptional Gene Silencing Spliceosomal Complex MRNA Splicing, Via Spliceosome MRNA Base-pairing Post-transcriptional Repressor Activity RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome RNA Binding MRNA Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleoplasm Nuclear Speck Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Regulation Of Primary Metabolic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Extracellular Vesicle Negative Regulation Of Translation Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Ribonucleoprotein Complex Pre-mRNA Binding MRNA 3'-UTR Binding Post-transcriptional Regulation Of Gene Expression U2-type Precatalytic Spliceosome Negative Regulation Of RNA Splicing Microtubule Nucleation