ATF7IP and HSPG2

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		ATF7IP	HSPG2
Description		activating transcription factor 7 interacting protein	heparan sulfate proteoglycan 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Nuclear Body	Extracellular Region Basement Membrane Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Extracellular Matrix Neuron Projection Lysosomal Lumen Extracellular Exosome Plasma Membrane Protein Complex
	Molecular Function	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding ATP Hydrolysis Activity	Amyloid-beta Binding Integrin Binding Calcium Ion Binding Protein Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Collagen V Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription	Angiogenesis Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Lipid Metabolic Process Receptor-mediated Endocytosis Inflammatory Response Negative Regulation Of Cell Adhesion Smoothened Signaling Pathway Brain Development Embryo Implantation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Negative Regulation Of Angiogenesis Cell Differentiation Animal Organ Regeneration Negative Regulation Of Neuron Apoptotic Process Circulatory System Development Negative Regulation Of Amyloid Fibril Formation
Pathways		PKMTs methylate histone lysines Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	Degradation of the extracellular matrix Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Amyloid fiber formation Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Formation of the dystrophin-glycoprotein complex (DGC)
Drugs			Palifermin
Diseases			Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Breast cancer ( 24143190) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Height ( 31562340 33713608) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Leukocyte telomere length ( 32109421) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate-specific antigen levels ( 23359319) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240 28604728 28604732)	Atrial fibrillation ( 30061737) Cerebral microbleeds (lobar) ( 32913026) Height ( 28552196) PR interval ( 32439900)
Interacting Genes		71 interacting genes: A2M ACTB ACTG1 AP1B1 CADM1 CEP250 COL4A2 CREB1 CREBBP CSPG4 DISC1 DMTF1 DNM2 EHMT2 EPG5 FLNB FLT4 GMEB1 GTF2E2 GTF2F1 GTF2H1 HEYL HLA-B HMGB1 HSPG2 KIF13A KRT7 LAMA4 LAMA5 LAMC1 LUC7L2 MACF1 MBD1 MCAM MED4 MRI1 NOMO1 NPR1 PAPPA PAPPA2 PCDH1 PEX6 PIAS3 PKD1 PLEKHB2 POLR2C POLR2D POLR2G PRSS8 PSG3 QRICH1 RPS3A RRBP1 SENP3 SETDB1 SLC12A4 SMAD4 SP1 SPTBN1 SREBF2 STBD1 STRN SUMO2 SUSD1 SVEP1 TRIP12 TTC3 UBE2I ZBTB6 ZNF350 ZNF518A	33 interacting genes: APP ATF7IP ATN1 BMP1 CACNA1A CCN2 COL13A1 ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN HSP90AA1 ITGA2 ITGB1 LAMA1 MTDH NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TCAP TTR UBC VWA1
Entrez ID		55729	3339
HPRD ID		09811	00804
Ensembl ID		ENSG00000171681	ENSG00000142798
Uniprot IDs		B3KNI7 B3KQF8 Q6VMQ6	P98160
PDB IDs		2RPQ	3SH4 3SH5
Enriched GO Terms of Interacting Partners?		Transcription By RNA Polymerase II DNA-templated Transcription Morphogenesis Of A Polarized Epithelium Transcription Initiation At RNA Polymerase II Promoter Nucleoplasm DNA-templated Transcription Initiation Basement Membrane Laminin-11 Complex Laminin-10 Complex Lymph Vessel Morphogenesis RNA Polymerase II, Core Complex Nucleobase-containing Compound Biosynthetic Process SUMO Transferase Activity Regulation Of Transepithelial Transport Dense Body Regulation Of Multicellular Organismal Development Nuclear Thyroid Hormone Receptor Binding Presynaptic Cytosol Macromolecule Biosynthetic Process Postsynaptic Cytosol Structural Constituent Of Postsynaptic Actin Cytoskeleton Maintenance Of Blood-brain Barrier Proximal Tubule Development Focal Adhesion DNA-directed RNA Polymerase Complex Golgi To Plasma Membrane Protein Transport Histone H3K9me2 Methyltransferase Activity DNA Methylation-dependent Constitutive Heterochromatin Formation Extracellular Exosome Positive Regulation Of Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Histone H3K9 Methyltransferase Activity Nucleus	Extracellular Matrix Structural Constituent Extracellular Matrix Extracellular Region Extracellular Space Basement Membrane Heparin Binding Collagen Binding Positive Regulation Of Cell Migration Integrin Binding Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Cell-matrix Adhesion Regulation Of Cell Motility Regulation Of Locomotion Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet Alpha Granule Lumen Regulation Of Endothelial Cell Proliferation Chemoattractant Activity Growth Factor Activity Peptidase Activator Activity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Endoplasmic Reticulum Lumen Integrin-mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Positive Chemotaxis Positive Regulation Of Cell Communication Positive Regulation Of Epithelial Cell Proliferation Response To Wounding Positive Regulation Of Endothelial Cell Migration Cell Adhesion Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Developmental Process Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Animal Organ Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?