ATF7IP and STRN

Number of citations: 54 (PubMedID 15231748)
Data Source: HPRD (two hybrid)

		ATF7IP	STRN
Name		activating transcription factor 7 interacting protein	striatin
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Nuclear Body	Cytoplasm Cytosol Bicellular Tight Junction Postsynaptic Density Membrane Cell Junction Dendrite Cell Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane FAR/SIN/STRIPAK Complex Postsynapse
	Molecular Function	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding ATP Hydrolysis Activity	Protein Binding Calmodulin Binding Nuclear Estrogen Receptor Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding Protein Phosphatase 2A Binding Armadillo Repeat Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription	Locomotory Behavior Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Wnt Signaling Pathway Dendrite Development Bicellular Tight Junction Assembly
Pathways		PKMTs methylate histone lysines Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Extra-nuclear estrogen signaling Signaling by cytosolic PDGFRA and PDGFRB fusion proteins ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
GWAS		Breast cancer ( 24143190 ) Cognitive ability (MTAG) ( 29186694 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Height ( 31562340 33713608 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Leukocyte telomere length ( 32109421 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Prostate-specific antigen levels ( 23359319 ) Testicular germ cell cancer ( 20543847 ) Testicular germ cell tumor ( 23666240 28604728 28604732 )	Alanine aminotransferase levels ( 33547301 ) Alanine transaminase levels ( 29403010 ) Appendicular lean mass ( 33097823 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cognitive decline (age-related) ( 28078323 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) High light scatter reticulocyte percentage of red cells ( 27863252 ) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597 ) Immature fraction of reticulocytes ( 27863252 ) Mean platelet volume ( 32888494 ) Metabolite levels ( 23823483 ) PR interval ( 32439900 ) QRS duration ( 27659466 27577874 ) Red cell distribution width ( 32888494 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) TPE interval (resting) ( 32386560 ) Triglyceride levels ( 32203549 32154731 )
Interacting Genes		71 interacting genes: A2M ACTB ACTG1 AP1B1 CADM1 CEP250 COL4A2 CREB1 CREBBP CSPG4 DISC1 DMTF1 DNM2 EHMT2 EPG5 FLNB FLT4 GMEB1 GTF2E2 GTF2F1 GTF2H1 HEYL HLA-B HMGB1 HSPG2 KIF13A KRT7 LAMA4 LAMA5 LAMC1 LUC7L2 MACF1 MBD1 MCAM MED4 MRI1 NOMO1 NPR1 PAPPA PAPPA2 PCDH1 PEX6 PIAS3 PKD1 PLEKHB2 POLR2C POLR2D POLR2G PRSS8 PSG3 QRICH1 RPS3A RRBP1 SENP3 SETDB1 SLC12A4 SMAD4 SP1 SPTBN1 SREBF2 STBD1 STRN SUMO2 SUSD1 SVEP1 TRIP12 TTC3 UBE2I ZBTB6 ZNF350 ZNF518A	12 interacting genes: ATF7IP CALM1 CAV1 ESR1 GNAI1 LNX1 PDCD10 PPP2CA PPP2R1A PPP2R1B RINT1 TFIP11
Entrez ID		55729	6801
HPRD ID		09811	18124
Ensembl ID		ENSG00000171681	ENSG00000115808
Uniprot IDs		B3KNI7 B3KQF8 Q6VMQ6	O43815
PDB IDs		2RPQ	Not available
GO Terms Enriched among Interactors		Transcription By RNA Polymerase II DNA-templated Transcription Morphogenesis Of A Polarized Epithelium Transcription Initiation At RNA Polymerase II Promoter Nucleoplasm DNA-templated Transcription Initiation Basement Membrane Laminin-11 Complex Laminin-10 Complex Lymph Vessel Morphogenesis RNA Polymerase II, Core Complex Nucleobase-containing Compound Biosynthetic Process SUMO Transferase Activity Regulation Of Transepithelial Transport Dense Body Regulation Of Multicellular Organismal Development Nuclear Thyroid Hormone Receptor Binding Presynaptic Cytosol Macromolecule Biosynthetic Process Postsynaptic Cytosol Structural Constituent Of Postsynaptic Actin Cytoskeleton Maintenance Of Blood-brain Barrier Proximal Tubule Development Focal Adhesion DNA-directed RNA Polymerase Complex Golgi To Plasma Membrane Protein Transport Histone H3K9me2 Methyltransferase Activity DNA Methylation-dependent Constitutive Heterochromatin Formation Extracellular Exosome Positive Regulation Of Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Histone H3K9 Methyltransferase Activity Nucleus	FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Meiotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Meiotic Sister Chromatid Cohesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Communication By Electrical Coupling Intracellular Signal Transduction INTAC Complex Regulation Of Cell Cycle Process RNA Polymerase II Transcription Initiation Surveillance Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Hippo Signaling Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Kinase Binding T Cell Homeostasis Nuclear RNA Surveillance Membrane Raft Fibroblast Proliferation RNA Surveillance Sister Chromatid Cohesion Protein Phosphatase Regulator Activity Regulation Of Hippo Signaling Transcription Elongation By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Cycle Regulation Of Cell Communication Regulation Of Muscle System Process Regulation Of Signaling Inward Rectifier Potassium Channel Inhibitor Activity Negative Regulation Of Endothelial Cell Proliferation RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity DNA-templated Transcription Elongation RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Meiotic Spindle Elongation Regulation Of Action Potential Regulation Of Nitric Oxide Biosynthetic Process Response To Estrogen Lymphocyte Homeostasis Regulation Of Nitric Oxide Metabolic Process Transcription By RNA Polymerase II Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Contraction Response To Metal Ion