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ATF7IP and PAPPA
Number of citations of the paper that reports this interaction (PubMedID
15231748
)
54
Data Source:
HPRD
(two hybrid)
ATF7IP
PAPPA
Description
activating transcription factor 7 interacting protein
pappalysin 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytosol
Nuclear Body
Extracellular Region
Extracellular Space
Molecular Function
Transcription Coregulator Activity
Transcription Corepressor Activity
Protein Binding
ATP Hydrolysis Activity
Endopeptidase Activity
Metalloendopeptidase Activity
Protein Binding
Peptidase Activity
Metallopeptidase Activity
Zinc Ion Binding
Hydrolase Activity
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
DNA Methylation-dependent Constitutive Heterochromatin Formation
Regulation Of DNA-templated Transcription
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Proteolysis
Cell Surface Receptor Signaling Pathway
Female Pregnancy
Pathways
PKMTs methylate histone lysines
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Phenethyl Isothiocyanate
Diseases
GWAS
Breast cancer (
24143190
)
Cognitive ability (MTAG) (
29186694
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Height (
31562340
33713608
)
Household income (MTAG) (
31844048
)
Intelligence (MTAG) (
29326435
)
Leukocyte telomere length (
32109421
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Prostate-specific antigen levels (
23359319
)
Testicular germ cell cancer (
20543847
)
Testicular germ cell tumor (
23666240
28604728
28604732
)
Appendicular lean mass (
33097823
)
Birth weight (
31043758
)
Brain morphology (MOSTest) (
32665545
)
Conotruncal heart defects (
24800985
)
Haemorrhoidal disease (
33888516
)
Heel bone mineral density (
28869591
)
Height (
18391950
20881960
28552196
)
Hip circumference adjusted for BMI (
34021172
)
Intralaminar thalamic nuclei volume (
34006833
)
Metabolite levels (
23823483
)
Pulse pressure (
30224653
)
Symptoms in placebo-treated COVID-19 outpatients at risk of severe disease (time to remission) (
34035401
)
Interacting Genes
71 interacting genes:
A2M
ACTB
ACTG1
AP1B1
CADM1
CEP250
COL4A2
CREB1
CREBBP
CSPG4
DISC1
DMTF1
DNM2
EHMT2
EPG5
FLNB
FLT4
GMEB1
GTF2E2
GTF2F1
GTF2H1
HEYL
HLA-B
HMGB1
HSPG2
KIF13A
KRT7
LAMA4
LAMA5
LAMC1
LUC7L2
MACF1
MBD1
MCAM
MED4
MRI1
NOMO1
NPR1
PAPPA
PAPPA2
PCDH1
PEX6
PIAS3
PKD1
PLEKHB2
POLR2C
POLR2D
POLR2G
PRSS8
PSG3
QRICH1
RPS3A
RRBP1
SENP3
SETDB1
SLC12A4
SMAD4
SP1
SPTBN1
SREBF2
STBD1
STRN
SUMO2
SUSD1
SVEP1
TRIP12
TTC3
UBE2I
ZBTB6
ZNF350
ZNF518A
12 interacting genes:
ATF7IP
C3
CREBBP
IGFBP4
KLHL20
PLG
PRG2
SKIL
SMAD2
SMAD3
SMAD9
TNNI3
Entrez ID
55729
5069
HPRD ID
09811
01448
Ensembl ID
ENSG00000171681
ENSG00000182752
Uniprot IDs
B3KNI7
B3KQF8
Q6VMQ6
B4DTA8
Q13219
Q7Z613
PDB IDs
2RPQ
7UFG
7Y5N
7Y5Q
8A7D
8A7E
8D8O
8HGG
8HGH
Enriched GO Terms of Interacting Partners
?
Transcription By RNA Polymerase II
DNA-templated Transcription
Morphogenesis Of A Polarized Epithelium
Transcription Initiation At RNA Polymerase II Promoter
Nucleoplasm
DNA-templated Transcription Initiation
Basement Membrane
Laminin-11 Complex
Laminin-10 Complex
Lymph Vessel Morphogenesis
RNA Polymerase II, Core Complex
Nucleobase-containing Compound Biosynthetic Process
SUMO Transferase Activity
Regulation Of Transepithelial Transport
Dense Body
Regulation Of Multicellular Organismal Development
Nuclear Thyroid Hormone Receptor Binding
Presynaptic Cytosol
Macromolecule Biosynthetic Process
Postsynaptic Cytosol
Structural Constituent Of Postsynaptic Actin Cytoskeleton
Maintenance Of Blood-brain Barrier
Proximal Tubule Development
Focal Adhesion
DNA-directed RNA Polymerase Complex
Golgi To Plasma Membrane Protein Transport
Histone H3K9me2 Methyltransferase Activity
DNA Methylation-dependent Constitutive Heterochromatin Formation
Extracellular Exosome
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of Transcription By RNA Polymerase II
Histone H3K9 Methyltransferase Activity
Nucleus
Transcription Regulator Complex
SMAD Protein Complex
Heteromeric SMAD Protein Complex
I-SMAD Binding
SMAD Protein Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Paraxial Mesoderm Morphogenesis
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Mesoderm Morphogenesis
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Pericardium Development
Trophoblast Cell Migration
Intracellular Signaling Cassette
Embryonic Foregut Morphogenesis
Nodal Signaling Pathway
Co-SMAD Binding
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Primary MiRNA Processing
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Response To Growth Factor
Transforming Growth Factor Beta Receptor Binding
Lens Fiber Cell Differentiation
Regulation Of Cellular Response To Growth Factor Stimulus
Intracellular Signal Transduction
Homeostatic Process
R-SMAD Binding
Embryonic Cranial Skeleton Morphogenesis
Activin Receptor Signaling Pathway
Chromatin Binding
DNA-binding Transcription Factor Binding
MiRNA Processing
Endoderm Development
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Positive Regulation Of Signal Transduction
Ureteric Bud Development
Negative Regulation Of Ossification
Tau Protein Binding
Epithelium Development
Positive Regulation Of Multicellular Organismal Process
Gastrulation
Mesonephric Epithelium Development
Mesonephric Tubule Development
SMAD Binding
Mesoderm Formation
Protein Domain Specific Binding
Transcription Coactivator Binding
Phosphatase Binding
Positive Regulation Of Cell Communication
C5L2 Anaphylatoxin Chemotactic Receptor Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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