PRF1 and TRIM54

Number of citations of the paper that reports this interaction (PMID 17360532)
20

Data Source:
BioGRID (two hybrid)

		PRF1	TRIM54
Gene Name		perforin 1 (pore forming protein)	tripartite motif containing 54
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Endosome Lumen Cytolytic Granule	Microtubule Microtubule Associated Complex Z Disc
	Molecular Function	Calcium Ion Binding Protein Binding Wide Pore Channel Activity	Signal Transducer Activity Microtubule Binding Zinc Ion Binding
	Biological Process	Immunological Synapse Formation Defense Response To Tumor Cell Immune Response To Tumor Cell Apoptotic Process Cellular Defense Response Cytolysis Protein Homooligomerization Defense Response To Virus Transmembrane Transport	Microtubule-based Process Negative Regulation Of Microtubule Depolymerization Signal Transduction Multicellular Organismal Development Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Obesity (extreme) ( 19553259)
Protein-Protein Interactions		5 interactors: CALR DDX24 GZMB KRT31 TRIM54	127 interactors: ADCY4 ALS2CR11 ARFIP2 ARHGEF5 ATXN3 ATXN3L ATXN7 BYSL C12orf49 C1orf109 C1orf216 C1QTNF2 CALM3 CARD9 CCDC102B CCDC146 CCDC28A CCDC67 CCDC87 CDK18 CDKN1A CEP57L1 CHCHD2 CKM CRADD CWF19L2 CYTH4 DCUN1D1 DNAL4 DTX2 EHHADH EIF4E2 ELMO1 ENKD1 EPM2AIP1 EXOSC5 FAM110A FAM124A FAM124B FAM161A FARS2 FBF1 FLNC GEM GMCL1 GTF2IRD2 HAUS1 ING3 INPP5J IQUB JOSD1 KDM1A KIFC3 KLHL38 KPNA2 KRT6A KRT6B KRT6C LENG1 LIN37 LMO2 LNX1 LSM2 MAPK3 MBD3 MCM7 MEAF6 MFAP1 MID2 MYO5B NGLY1 OSTF1 OTUB1 OTUB2 PIK3R3 PPP1R18 PRF1 RABGEF1 RAD23A RBM41 RCOR3 RSRC2 SCNM1 SDCBP SENP3 SH2D1B SMARCE1 SNF8 SPG21 SSX2IP STAM STRA13 TBC1D22B TCEA2 TCEB3 THOC1 TRIM55 TRIM63 TSHZ3 TTC23 UBE2D3 UBE2I UBE2U UCHL1 UCHL3 UCHL5 USHBP1 USP15 USP18 USP2 USP21 USP33 USP4 USP5 USP7 USP8 UTP14C VPS28 WDR34 WDYHV1 YOD1 ZBTB16 ZGPAT ZNF250 ZNF417 ZNF572 ZNF587
Entrez ID		5551	57159
HPRD ID		01362	05928
Ensembl ID		ENSG00000180644	ENSG00000138100
Uniprot IDs		P14222	Q9BYV2
PDB IDs			3Q1D
Enriched GO Terms of Interacting Partners?		Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Organelle Organization Sequestering Of Calcium Ion Granzyme-mediated Apoptotic Signaling Pathway Positive Regulation Of Dendritic Cell Chemotaxis	Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Proteolysis Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Cellular Protein Metabolic Process Regulation Of Metabolic Process Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Organelle Organization Regulation Of Protein Catabolic Process Protein Metabolic Process Histone Deubiquitination RNA Metabolic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Process Monoubiquitinated Protein Deubiquitination Histone Modification Gene Expression RNA Biosynthetic Process Chromatin Modification Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Regulation Of Proteolysis Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Chromatin Organization Cellular Response To DNA Damage Stimulus Nitrogen Compound Metabolic Process Chromosome Organization Cellular Response To Heat Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		272c ala91val analysed backgrounds cd8 confers ebv extranasal familial fhlh haemophagocytic immunophenotype lymphohistiocytosis manifestations nasal nk nktcl nktcls none origin overexpressed overlap pathogenic perforin snp snvs tumoral tumours validation
Tagcloud (Difference) ?		272c ala91val analysed backgrounds cd8 confers ebv extranasal familial fhlh haemophagocytic immunophenotype lymphohistiocytosis manifestations nasal nk nktcl nktcls none origin overexpressed overlap pathogenic perforin snp snvs tumoral tumours validation
Tagcloud (Intersection) ?