PRF1 and GZMB

Number of citations of the paper that reports this interaction (PubMedID 8770355)
0

Data Source:
HPRD (in vivo)

		PRF1	GZMB
Description		perforin 1	granzyme B
Image		No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Lysosome Endosome Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Endosome Lumen Cytolytic Granule Cytolytic Granule Lumen	Immunological Synapse Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Membrane Cytolytic Granule Cytolytic Granule Lumen
	Molecular Function	Calcium Ion Binding Protein Binding Wide Pore Channel Activity Identical Protein Binding Metal Ion Binding Pore-forming Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Immunological Synapse Formation Plasma Membrane Repair Leukocyte Mediated Cytotoxicity T Cell Mediated Cytotoxicity Defense Response To Tumor Cell Immune Response To Tumor Cell Positive Regulation Of Immune Response To Tumor Cell Apoptotic Process Cellular Defense Response Protein Secretion Protein Import Killing Of Cells Of Another Organism Ceramide Biosynthetic Process Protein Homooligomerization Protein Maturation Defense Response To Virus Positive Regulation Of Killing Of Cells Of Another Organism Protein Transmembrane Transport Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death	Plasma Membrane Repair Positive Regulation Of Immune Response To Tumor Cell Proteolysis Apoptotic Process Protein Secretion Negative Regulation Of Translation Killing Of Cells Of Another Organism Natural Killer Cell Mediated Cytotoxicity Ceramide Biosynthetic Process Proteolysis Involved In Protein Catabolic Process Protein Maturation Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death Positive Regulation Of Establishment Of Protein Localization To Mitochondrion
Pathways		Nuclear events stimulated by ALK signaling in cancer	NOTCH2 intracellular domain regulates transcription Pyroptosis Activation, myristolyation of BID and translocation to mitochondria Nuclear events stimulated by ALK signaling in cancer
Drugs
Diseases		Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS		Lymphocyte count ( 32888494) Multiple keratinocyte cancers ( 28081215) Obesity (extreme) ( 19553259) Type 1 diabetes ( 34012112)	Blood protein levels ( 30072576) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Interleukin-10 levels in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683) Vitiligo ( 20410501 27723757)
Interacting Genes		12 interacting genes: CALR CYSRT1 DDX24 GZMB KRT31 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-8 NBPF19 NOTCH2NLA TRIM54	26 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6
Entrez ID		5551	3002
HPRD ID		01362	00476
Ensembl ID		ENSG00000180644	ENSG00000100453
Uniprot IDs		P14222	J3KQ52 P10144 Q67BC3 Q6XGZ4
PDB IDs			1FQ3 1IAU
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Cytolytic Granule Epidermis Development	DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nonhomologous End Joining Complex Response To Radiation Positive Regulation Of Programmed Cell Death Programmed Cell Death Cell Death Regulation Of Programmed Cell Death DNA-dependent Protein Kinase Complex Apoptotic Process Regulation Of Apoptotic Process Response To Anesthetic Response To Ionizing Radiation Cellular Response To Stress Protein Processing Protein Maturation Response To Cobalt Ion Telomere Maintenance Pyroptotic Inflammatory Response Fibroblast Apoptotic Process Protein-DNA Complex Neuron Apoptotic Process Granzyme-mediated Programmed Cell Death Signaling Pathway Leukocyte Apoptotic Process Positive Regulation Of Apoptotic Process Response To Gamma Radiation Protein-containing Complex Telomere Organization Regulation Of Neuron Apoptotic Process Death Receptor Binding Double-strand Break Repair Via Nonhomologous End Joining Structural Constituent Of Nuclear Lamina Response To Stress Protein Poly-ADP-ribosylation Cysteine-type Endopeptidase Activity Response To UV Positive Regulation Of Neuron Apoptotic Process Enzyme Activator Activity Macromolecule Metabolic Process DNA End Binding Ku70:Ku80 Complex Small-subunit Processome Assembly Chromosome, Telomeric Region Execution Phase Of Apoptosis Response To Light Stimulus Regulation Of Immune Response Apoptotic Signaling Pathway Response To Metal Ion Immune System Process Response To X-ray Regulation Of Immune System Process
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