PRF1 and KRTAP1-3

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		PRF1	KRTAP1-3
Description		perforin 1	keratin associated protein 1-3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Lysosome Endosome Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Endosome Lumen Cytolytic Granule Cytolytic Granule Lumen	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Calcium Ion Binding Protein Binding Wide Pore Channel Activity Identical Protein Binding Metal Ion Binding Pore-forming Activity	Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Immunological Synapse Formation Plasma Membrane Repair Leukocyte Mediated Cytotoxicity T Cell Mediated Cytotoxicity Defense Response To Tumor Cell Immune Response To Tumor Cell Positive Regulation Of Immune Response To Tumor Cell Apoptotic Process Cellular Defense Response Protein Secretion Protein Import Killing Of Cells Of Another Organism Ceramide Biosynthetic Process Protein Homooligomerization Protein Maturation Defense Response To Virus Positive Regulation Of Killing Of Cells Of Another Organism Protein Transmembrane Transport Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death
Pathways		Nuclear events stimulated by ALK signaling in cancer	Keratinization
Drugs
Diseases		Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS		Lymphocyte count ( 32888494) Multiple keratinocyte cancers ( 28081215) Obesity (extreme) ( 19553259) Type 1 diabetes ( 34012112)
Interacting Genes		12 interacting genes: CALR CYSRT1 DDX24 GZMB KRT31 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-8 NBPF19 NOTCH2NLA TRIM54	183 interacting genes: ADAM12 AGA ALDH3B1 ALPP ATG9A BCAM BHLHE40 BMP7 BTC C19orf25 C2orf68 CATSPER1 CELF5 CHIC2 CHRD CHRNG CLDN2 CMTM8 CNNM3 COA5 COL8A1 CRCT1 CREB5 CRH CRY2 CTNNBIP1 CXCL16 CYP21A2 CYSRT1 DAGLB DHRS1 DLGAP3 DMRT3 DOCK2 ECE1 EMC7 FBXW5 FZD10 GLP1R GLRX3 GLYAT GNE GRAP2 GSTP1 HCK HHEX HHIPL1 HOXA1 HOXB9 HOXC8 HPCAL1 HSD3B7 IGSF8 IL10 IL16 INPP5D INS ITGB4 ITGB5 JOSD1 KLHL38 KLK8 KPRP KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LONRF1 LRFN4 MAPKBP1 MOS MTNR1A MXD3 MXI1 MYPOP NAXD NECTIN2 NECTIN3 NID2 NMU NPBWR2 NPDC1 NR1D2 NUFIP2 OLFM2 OTX1 P3H3 PDE9A PDIA5 PHETA1 PHLDA1 PIGS PLEKHN1 PRF1 PRKAA2 PRKAB2 PRPF31 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAMAC RANBP3 RASD1 RPN1 RPS19BP1 SAPCD2 SDC3 SDCBP SELENOM SHFL SLC13A5 SLC22A23 SLC23A1 SLC39A7 SLC43A2 SLC5A5 SLC7A11 SMCP SPINT1 SPRY1 STK16 SUSD6 TACSTD2 TCAF1 TFAP2D TGFB1 THAP7 TNS2 UNC119 UTP23 UXT VASN VSTM4 WNT11 XCL2 YIPF3 YY1 ZDHHC1 ZFTRAF1 ZNF330 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF587 ZNF696 ZNF764 ZNF786 ZNF837
Entrez ID		5551	81850
HPRD ID		01362	12305
Ensembl ID		ENSG00000180644	ENSG00000221880
Uniprot IDs		P14222	Q8IUG1
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Cytolytic Granule Epidermis Development	Epidermis Development Keratinization Protein Binding Intermediate Filament Keratin Filament Tissue Development Hair Cycle Susceptibility To T Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Animal Organ Morphogenesis Negative Regulation Of Defense Response Identical Protein Binding
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