PRF1

Description		perforin 1
Image		No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Lysosome Endosome Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Endosome Lumen Cytolytic Granule Cytolytic Granule Lumen
	Molecular Function	Calcium Ion Binding Protein Binding Wide Pore Channel Activity Identical Protein Binding Metal Ion Binding Pore-forming Activity
	Biological Process	Immunological Synapse Formation Plasma Membrane Repair Leukocyte Mediated Cytotoxicity T Cell Mediated Cytotoxicity Defense Response To Tumor Cell Immune Response To Tumor Cell Positive Regulation Of Immune Response To Tumor Cell Apoptotic Process Cellular Defense Response Protein Secretion Protein Import Killing Of Cells Of Another Organism Ceramide Biosynthetic Process Protein Homooligomerization Protein Maturation Defense Response To Virus Positive Regulation Of Killing Of Cells Of Another Organism Protein Transmembrane Transport Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death
Pathways		Nuclear events stimulated by ALK signaling in cancer
Drugs
Diseases		Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS		Lymphocyte count ( 32888494) Multiple keratinocyte cancers ( 28081215) Obesity (extreme) ( 19553259) Type 1 diabetes ( 34012112)
Interacting Genes		12 interacting genes: CALR CYSRT1 DDX24 GZMB KRT31 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-8 NBPF19 NOTCH2NLA TRIM54
Entrez ID		5551
HPRD ID		01362
Ensembl ID		ENSG00000180644
Uniprot IDs		P14222
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Cytolytic Granule Epidermis Development
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