PRF1

Gene Name		perforin 1 (pore forming protein)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Endosome Lumen Cytolytic Granule
	Molecular Function	Calcium Ion Binding Protein Binding Wide Pore Channel Activity
	Biological Process	Immunological Synapse Formation Defense Response To Tumor Cell Immune Response To Tumor Cell Apoptotic Process Cellular Defense Response Cytolysis Protein Homooligomerization Defense Response To Virus Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Obesity (extreme) ( 19553259)
Protein-protein Interactions		5 interactors: CALR DDX24 GZMB KRT31 TRIM54
Entrez ID		5551
HPRD ID		01362
Ensembl ID		ENSG00000180644
Uniprot IDs		P14222
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Organelle Organization Sequestering Of Calcium Ion Granzyme-mediated Apoptotic Signaling Pathway Positive Regulation Of Dendritic Cell Chemotaxis
Tagcloud ?		272c ala91val analysed backgrounds cd8 confers ebv extranasal familial fhlh haemophagocytic immunophenotype lymphohistiocytosis manifestations nasal nk nktcl nktcls none origin overexpressed overlap pathogenic perforin snp snvs tumoral tumours validation