PRF1 and KRT31

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PRF1	KRT31
Gene Name		perforin 1 (pore forming protein)	keratin 31, type I
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Endosome Lumen Cytolytic Granule	Extracellular Space Intermediate Filament Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Wide Pore Channel Activity	Structural Constituent Of Cytoskeleton
	Biological Process	Immunological Synapse Formation Defense Response To Tumor Cell Immune Response To Tumor Cell Apoptotic Process Cellular Defense Response Cytolysis Protein Homooligomerization Defense Response To Virus Transmembrane Transport	Epidermis Development
Pathways
Drugs
Diseases
GWAS		Obesity (extreme) ( 19553259)
Protein-Protein Interactions		5 interactors: CALR DDX24 GZMB KRT31 TRIM54	181 interactors: ABI2 AES AGR2 ALDH3B1 ALS2CR11 AMOT AMOTL2 ANKRD36BP1 AQP1 AQP5 ARHGAP35 ARMC7 ARSJ ASMTL ASPSCR1 ATG9A ATN1 ATXN7L1 BEX2 BTC BYSL C12orf49 C19orf73 C1orf109 C1orf216 C5orf60 C6orf165 CA6 CARD9 CARKD CATIP CCDC112 CCDC120 CCDC17 CCDC93 CCER1 CCHCR1 CCNC CD33 CDC20B CDK18 CDKN1A CEP57 CEP57L1 CEP70 CHCHD2 CHRNG CLDN2 COA5 COMT COX5A COX5B CRH CTSG DGCR6L DHX37 DMRT3 DTNB EIF4E2 EXOC8 FAM103A1 FAM110A FAM124B FAM71C FAM74A4 FAM90A1 FARS2 FBF1 FBXW5 FKBP1B FOXB1 GEM GFOD1 GLRX3 GNAI2 GNE GNG10 GNG5 GPS2 GSTP1 HAUS1 HDAC4 HGS HOXA1 HSPA12B HSPD1 ICAM4 INPP5D INPP5K INSR JOSD1 KIFC3 KLC1 KLC4 KLHL38 KRT2 KRT5 KRT6A KRT6B KRT6C KRT71 KRT77 KRT79 KRT8 KRT81 KRT83 LATS1 LCE4A LENG1 LIN37 LINC00238 LINC00526 LMF2 LMO4 LONRF1 MAP3K7CL MAPKBP1 MARK4 MRPL40 NAV1 NEK6 NPBWR2 OTUB2 P2RX7 PDE4DIP PGLS PIN1 PKN1 PPP1R18 PRF1 PRKAA2 PRR19 PSMA1 PSMG2 PSPC1 PTGER3 PTPMT1 RADIL RCOR3 RIBC1 RPUSD3 RSPH14 SCNM1 SEMA4C SHC3 SIRPA SLC15A3 SLC23A1 SLC25A6 SMARCE1 SMCP SMG9 SNAI1 SNRNP25 SPATA24 SPON2 SRSF2 SSX2IP TAPBPL THAP7 TMEM106C TMEM231 TMSB4X TRAF4 TROAP TSG101 TTC23 TXLNA USHBP1 UTP23 UXT WDR25 WDYHV1 ZFYVE21 ZNF124 ZNF148 ZNF20 ZNF569 ZNF572 ZNF69 ZNRF2P1
Entrez ID		5551	3881
HPRD ID		01362	03047
Ensembl ID		ENSG00000180644	ENSG00000094796
Uniprot IDs		P14222	Q15323
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Organelle Organization Sequestering Of Calcium Ion Granzyme-mediated Apoptotic Signaling Pathway Positive Regulation Of Dendritic Cell Chemotaxis	Cellular Process Organelle Organization Epidermis Development Anatomical Structure Development Developmental Process Negative Regulation Of Cellular Metabolic Process Cytoskeleton Organization Positive Regulation Of Urine Volume G2/M Transition Of Mitotic Cell Cycle Gene Expression Regulation Of Body Fluid Levels Epithelium Development RNA Metabolic Process Regulation Of Interleukin-6 Production Carbon Dioxide Transport Response To Organic Substance Regulation Of Glycolytic Process Mitotic Cell Cycle Process Hippo Signaling Negative Regulation Of Biosynthetic Process Positive Regulation Of Interleukin-6 Production Cell Cycle Negative Regulation Of Intracellular Signal Transduction Regulation Of Stress-activated MAPK Cascade Pancreatic Juice Secretion Microtubule Cytoskeleton Organization Movement Of Cell Or Subcellular Component Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Nuclear Division Regulation Of MAPK Cascade Regulation Of Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Cell Cycle Phase Transition Multicellular Organismal Development Bicarbonate Transport Cell Volume Homeostasis Cell Death Death Interaction With Symbiont Negative Regulation Of Signaling Transcription, DNA-templated Mitotic Cell Cycle Regulation Of Protein Metabolic Process Apoptotic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Response To Fungus Cellular Response To Extracellular Stimulus Cellular Metabolic Process Programmed Cell Death RNA Biosynthetic Process
Tagcloud ?		272c ala91val analysed backgrounds cd8 confers ebv extranasal familial fhlh haemophagocytic immunophenotype lymphohistiocytosis manifestations nasal nk nktcl nktcls none origin overexpressed overlap pathogenic perforin snp snvs tumoral tumours validation
Tagcloud (Difference) ?		272c ala91val analysed backgrounds cd8 confers ebv extranasal familial fhlh haemophagocytic immunophenotype lymphohistiocytosis manifestations nasal nk nktcl nktcls none origin overexpressed overlap pathogenic perforin snp snvs tumoral tumours validation
Tagcloud (Intersection) ?