AP1AR and AP1G1

Number of citations of the paper that reports this interaction (PMID 15775984)
14

Data Source:
HPRD (two hybrid, in vitro)

		AP1AR	AP1G1
Gene Name		adaptor-related protein complex 1 associated regulatory protein	adaptor-related protein complex 1, gamma 1 subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Late Endosome Golgi Apparatus Transport Vesicle	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Membrane AP-type Membrane Coat Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Kinesin Binding AP-1 Adaptor Complex Binding	Transporter Activity Protein Binding Protein Transporter Activity Rab GTPase Binding Kinesin Binding GTP-dependent Protein Binding
	Biological Process	Negative Regulation Of Receptor Recycling Protein Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Protein Localization Vesicle Targeting, Trans-Golgi To Endosome Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Cell Motility	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Organization Endosome To Melanosome Transport Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Defense Response To Virus By Virus Membrane Organization Golgi To Lysosome Transport
Pathways			Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: AP1G1 GGA1	20 interactors: AFTPH AP1AR AP1B1 AP1M2 AP1S1 AP1S2 ARF1 CLINT1 CLTC DNER KIF13A MAP1A RAB5A RABEP1 RABGEF1 SPTB SYNRG SYP UBL7 ZNF512B
Entrez ID		55435	164
HPRD ID		12824	04637
Ensembl ID		ENSG00000138660	ENSG00000166747
Uniprot IDs		Q63HQ0	O43747 Q8IY97
PDB IDs			1IU1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Natural Killer Cell Degranulation Golgi To Lysosome Transport Golgi To Vacuole Transport Endosome To Melanosome Transport Pigment Granule Maturation Cellular Pigment Accumulation Intracellular Protein Transport Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Regulated Secretory Pathway Melanosome Organization Pigment Granule Organization Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Defense Response To Virus By Virus Positive Regulation Of Natural Killer Cell Activation Regulation Of Regulated Secretory Pathway Cellular Protein Localization Protein Transport Vesicle-mediated Transport Lysosomal Transport Establishment Of Protein Localization Intracellular Transport Cellular Pigmentation Positive Regulation Of Exocytosis Developmental Pigmentation Protein Localization Vacuolar Transport Regulation Of Defense Response To Virus Establishment Of Localization In Cell Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Pigmentation Cellular Localization Regulation Of Exocytosis Positive Regulation Of Innate Immune Response Endosomal Transport Vesicle Organization Positive Regulation Of Protein Catabolic Process Antigen Processing And Presentation Of Peptide Antigen Regulation Of Innate Immune Response Golgi Vesicle Transport Antigen Processing And Presentation Positive Regulation Of Cell Activation Positive Regulation Of Secretion	Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport Membrane Organization Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Regulation Of Defense Response To Virus By Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Protein Localization Intracellular Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Establishment Of Localization In Cell Endocytosis Cellular Localization Regulation Of Defense Response To Virus Transport Establishment Of Vesicle Localization Intracellular Protein Transport Vesicle Localization Cellular Protein Localization Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Establishment Of Organelle Localization Organelle Localization Vesicle Targeting Vesicle Organization Viral Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Nucleation Vesicle Targeting, To, From Or Within Golgi Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Immune System Process Regulation Of Endocytosis Synaptic Vesicle Recycling Receptor Internalization Endosomal Transport Negative Regulation Of Kit Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Immune System Process Vesicle Targeting, Trans-Golgi To Endosome Synaptic Vesicle Membrane Organization Regulation Of Synaptic Transmission Membrane Budding Receptor Metabolic Process Receptor Internalization Involved In Canonical Wnt Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Endosome Size Regulation Of Opioid Receptor Signaling Pathway
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