AP1AR and KLC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AP1AR	KLC1
Description		adaptor related protein complex 1 associated regulatory protein	kinesin light chain 1
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Early Endosome Late Endosome Golgi Apparatus Cytosol Transport Vesicle	Cytoplasm Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Growth Cone Cytoplasmic Vesicle Cell Projection
	Molecular Function	Protein Binding Kinesin Binding AP-1 Adaptor Complex Binding	Cytoskeletal Motor Activity Protein Binding Kinesin Binding
	Biological Process	Negative Regulation Of Receptor Recycling Intracellular Protein Localization Protein Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Substrate Adhesion-dependent Cell Spreading Vesicle Targeting, Trans-Golgi To Endosome Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Cell Motility	Microtubule-based Movement Cell Adhesion Stress Granule Disassembly
Pathways			MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants Kinesins
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 25673413 28892062) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061) Smoking behaviour (cigarette pack-years) ( 30679032) Urate levels ( 31578528)
Interacting Genes		3 interacting genes: AP1G1 GGA1 KLC1	29 interacting genes: ADRB2 AP1AR APP ATCAY BNIP2 CLSTN1 ERBB2 F2RL1 HSPB1 KIF2A KIF5C KLC2 KRT31 LRSAM1 MAPK6 MAPK8IP1 MAPK8IP2 MAPK8IP3 NIN ODAD1 ODF1 PCM1 PLEKHM2 PTGER4 SNCA SPAG9 TACC3 TSC1 YWHAB
Entrez ID		55435	3831
HPRD ID		12824	02489
Ensembl ID		ENSG00000138660	ENSG00000126214
Uniprot IDs		Q63HQ0	F8W6L3 G3V2E7 G3V3H3 G3V5R9 G5E9S8 Q07866 Q7RTQ2
PDB IDs			3NF1 5OJ8 7AI4 7AIE
Enriched GO Terms of Interacting Partners?		Kinesin Binding Post-Golgi Vesicle-mediated Transport Cytosolic Transport Synaptic Vesicle Budding From Endosome Trans-Golgi Network Small GTPase Binding Basolateral Protein Secretion Positive Regulation Of Natural Killer Cell Degranulation Golgi Vesicle Transport Early Endosome Stress Granule Disassembly Protein Localization To Ciliary Membrane Endosome To Melanosome Transport Golgi To Lysosome Transport AP-1 Adaptor Complex Clathrin Adaptor Activity Intracellular Protein Transport Melanosome Assembly Golgi To Vacuole Transport Intracellular Vesicle GTP-dependent Protein Binding Platelet Dense Granule Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Membrane Coat Protein Localization To Cell Surface Positive Regulation Of Natural Killer Cell Mediated Immunity Clathrin-coated Vesicle Membrane Vesicle Budding From Membrane Synaptic Vesicle Endocytosis Melanosome Organization Pigment Granule Organization Golgi To Plasma Membrane Protein Transport Cytoplasmic Vesicle Presynaptic Endocytosis Kinesin Complex Positive Regulation Of Regulated Secretory Pathway Cytoskeletal Motor Activity Regulation Of Natural Killer Cell Mediated Cytotoxicity Establishment Of Protein Localization To Plasma Membrane Regulation Of Natural Killer Cell Mediated Immunity Protein Localization To Cilium Golgi To Plasma Membrane Transport Collagen Binding Protein Transport Positive Regulation Of Leukocyte Mediated Cytotoxicity Secretory Granule Organization Positive Regulation Of Cell Killing Clathrin-coated Pit Clathrin-coated Vesicle Vesicle-mediated Transport	Kinesin Binding MAP-kinase Scaffold Activity JUN Kinase Binding Protein Localization To Synapse Positive Regulation Of MAPK Cascade Microtubule-based Process Perinuclear Region Of Cytoplasm Microtubule-based Movement Protein Localization To Cell Junction Anterograde Axonal Protein Transport Protein Transport Along Microtubule Organelle Localization Regulation Of MAPK Cascade MAPK Cascade Regulation Of JNK Cascade Cytoskeleton Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Projection Axonal Growth Cone Axo-dendritic Transport Transport Along Microtubule Ciliary Basal Body Lysosome Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Protein-containing Complex Leukocyte Activation Anterograde Axonal Transport Protein Kinase Inhibitor Activity Kinesin Complex Axon Modulation Of Excitatory Postsynaptic Potential Receptor Localization To Synapse Positive Regulation Of Signal Transduction Centriolar Subdistal Appendage Mitotic Spindle Growth Cone Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Projection Organization Intracellular Signaling Cassette Lysosome Localization Microtubule Anchoring At Centrosome Regulation Of G Protein-coupled Receptor Signaling Pathway Cytoplasm Cell Activation JNK Cascade
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