PPP3R1 and MAP3K5

Number of citations of the paper that reports this interaction (PubMedID 16648474)
62

Data Source:
HPRD (two hybrid, in vitro)

		PPP3R1	MAP3K5
Description		protein phosphatase 3 regulatory subunit B, alpha	mitogen-activated protein kinase kinase kinase 5
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Calcineurin Complex Protein Serine/threonine Phosphatase Complex Membrane Sarcolemma Synapse Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Parallel Fiber To Purkinje Cell Synapse Postsynapse Glutamatergic Synapse	Cytoplasm Endoplasmic Reticulum Cytosol External Side Of Plasma Membrane Protein-containing Complex Protein Kinase Complex IRE1-TRAF2-ASK1 Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Phosphatase Binding Protein Domain Specific Binding Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Epithelial To Mesenchymal Transition Protein Import Into Nucleus Heart Development Schwann Cell Development Myelination In Peripheral Nervous System Calcineurin-NFAT Signaling Cascade Protein Localization To Nucleus Positive Regulation Of Transcription By RNA Polymerase II Lung Epithelial Cell Differentiation Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Synaptic Vesicle Cycle Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Import Across Plasma Membrane	MAPK Cascade Immune System Process Response To Ischemia Apoptotic Process JNK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress P38MAPK Cascade Positive Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Neuron Apoptotic Process Stress-activated MAPK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Endothelial Cell Apoptotic Process Cellular Senescence Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of P38MAPK Cascade Cellular Response To Reactive Nitrogen Species Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Activation of BAD and translocation to mitochondria DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation	Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence
Drugs		Myristic acid Voclosporin
Diseases
GWAS		General cognitive ability ( 29844566) Height ( 25282103) Hip index ( 34021172) Intelligence (MTAG) ( 29326435) Schizophrenia ( 30285260) Urinary potassium excretion ( 31409800)	Eosinophil count ( 32888494) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		12 interacting genes: CABP1 CABP2 CABP5 CHRNA6 MAP3K5 MYC NAP1L2 NFATC1 NFATC2 PPP3CA PPP3CC RCAN1	69 interacting genes: AKT1 ARRB2 AURKA BIRC2 CCND2 CDC25A CDC25C CDK4 CDK6 CDKN1A CDKN2A CIB1 CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 FGFR4 FZR1 GADD45B GEMIN5 GLIS2 GLRX GSTM1 HSPA1A IGF1R JAK2 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L NF2 PDCD6 PPP3R1 PPP5C PRMT1 PTPN11 QARS1 RAF1 SFN SIAH1 STK11 TEAD2 TERT TNFAIP3 TNFAIP8L1 TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TULP3 TXN UBE2I USP9X YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		5534	4217
HPRD ID		03195	03904
Ensembl ID		ENSG00000221823	ENSG00000197442
Uniprot IDs		P63098	A0A8V8TMH5 Q99683
PDB IDs		1AUI 1M63 1MF8 2P6B 3LL8 4F0Z 4OR9 4ORA 4ORC 5SVE 6NUC 6NUF 6NUU 7U0T 9B9G 9CHU 9CHV 9CHX	2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE 5ULM 5UOR 5UOX 5UP3 5V19 5V24 5VIL 5VIO 6E2M 6E2N 6E2O 6EJL 6OYT 6OYW 6VRE 6XIH 7MU6 7MU7 8QGY
Enriched GO Terms of Interacting Partners?		Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Calcium-mediated Signaling Negative Regulation Of Smooth Muscle Cell Differentiation Intracellular Signaling Cassette Myotube Cell Development Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Smooth Muscle Cell Differentiation Calmodulin-dependent Protein Phosphatase Activity Calcium Channel Regulator Activity Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Signal Transduction Striated Muscle Cell Development Negative Regulation Of Muscle Cell Differentiation Protein Serine/threonine Phosphatase Complex Positive Regulation Of Kidney Development Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Muscle Cell Development Regulation Of Calcium-mediated Signaling Regulation Of Cell Differentiation Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Cell Differentiation Regulation Of Developmental Process Intracellular Signal Transduction Positive Regulation Of Calcium Ion Import Skeletal Muscle Fiber Development Regulation Of Muscle Cell Differentiation Regulation Of Kidney Development Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Developmental Process Regulation Of Calcium Ion Import Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Negative Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of Calcium Ion Transport Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Axonemal Basal Plate Positive Regulation Of Calcium-mediated Signaling Calcium Ion Binding Positive Regulation Of Calcium Ion Transmembrane Transport Response To Ischemia Excitatory Postsynaptic Potential Negative Regulation Of Cation Transmembrane Transport	Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of MAPK Cascade Signal Transduction Cytosol Cytoplasm Positive Regulation Of MAPK Cascade Cellular Response To Stress Regulation Of Protein Metabolic Process MAPK Cascade Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Regulation Of Apoptotic Process Protein Kinase Binding Protein Modification Process Positive Regulation Of Protein Metabolic Process Transferase Activity Enzyme Binding Regulation Of Primary Metabolic Process Protein Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Positive Regulation Of Metabolic Process Protein Serine Kinase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Regulation Of JNK Cascade Kinase Activity Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Catalytic Activity Identical Protein Binding Negative Regulation Of Signal Transduction Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Protein Metabolic Process Regulation Of Innate Immune Response
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