PPP3R1 and NAP1L2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PPP3R1	NAP1L2
Gene Name		protein phosphatase 3, regulatory subunit B, alpha	nucleosome assembly protein 1-like 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Calcineurin Complex Sarcolemma	Nucleus
	Molecular Function	Calcium-dependent Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Protein Domain Specific Binding	Chromatin Binding Protein Binding Histone Binding
	Biological Process	Apoptotic Process Dephosphorylation Calcineurin-NFAT Signaling Cascade Fc-epsilon Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of NFAT Protein Import Into Nucleus Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Nucleosome Assembly Positive Regulation Of Neuron Differentiation Positive Regulation Of Histone H3-K14 Acetylation Regulation Of Stem Cell Division Positive Regulation Of Histone H3-K9 Acetylation
Pathways		Signaling by GPCR Opioid Signalling Activation of BH3-only proteins Signaling by Wnt beta-catenin independent WNT signaling Activation of BAD and translocation to mitochondria Ca2+ pathway Programmed Cell Death DARPP-32 events Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Intrinsic Pathway for Apoptosis Innate Immune System
Drugs		MYRISTIC ACID
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CABP1 CABP2 CABP5 MAP3K5 NAP1L2 NFATC1 NFATC2 PPP3CA	2 interactors: PPP3R1 SP110
Entrez ID		5534	4674
HPRD ID		03195	02066
Ensembl ID		ENSG00000221823	ENSG00000186462
Uniprot IDs		D3YTA9 P63098	Q9ULW6
PDB IDs		1AUI 1M63 1MF8 2P6B 3LL8 4F0Z
Enriched GO Terms of Interacting Partners?		Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Transition Between Fast And Slow Fiber Negative Regulation Of Cell Communication By Electrical Coupling Immune Response-regulating Signaling Pathway Immune Response Defense Response Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Histone H3-K14 Acetylation Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Histone H3-K14 Acetylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Transport Regulation Of Protein Localization To Nucleus Calcineurin-NFAT Signaling Cascade Negative Regulation Of Voltage-gated Calcium Channel Activity Signal Transduction Regulation Of Nucleocytoplasmic Transport Regulation Of Stem Cell Division Regulation Of Skeletal Muscle Adaptation Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Metabolic Process Regulation Of Immune Response Positive Regulation Of NFAT Protein Import Into Nucleus Mitotic Cell Cycle Phase Transition Signaling Cell Cycle Phase Transition Regulation Of Intracellular Protein Transport Cell Communication Immune System Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Regulation Of Histone H3-K9 Acetylation Regulation Of Cell Communication By Electrical Coupling Calcium Ion Transport Inositol Phosphate-mediated Signaling Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Skeletal Muscle Fiber Development Negative Regulation Of Transport Regulation Of Immune System Process Cellular Response To Stimulus Positive Regulation Of Histone Acetylation Positive Regulation Of Transcription, DNA-templated	Positive Regulation Of NFAT Protein Import Into Nucleus Calcineurin-NFAT Signaling Cascade Inositol Phosphate-mediated Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Transcription Factor Import Into Nucleus
Tagcloud ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	1c acetylated acetylation assembly associates cdkn1c chromatin correlates defects deficiencies differentiating downregulation establishment h3k9 h4 histones idea interacts maintenance marked mediate modification neural neurogenesis neuronal normally nucleosome permissive tube
Tagcloud (Difference) ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	1c acetylated acetylation assembly associates cdkn1c chromatin correlates defects deficiencies differentiating downregulation establishment h3k9 h4 histones idea interacts maintenance marked mediate modification neural neurogenesis neuronal normally nucleosome permissive tube
Tagcloud (Intersection) ?