PPP3R1 and PPP3CA

Number of citations of the paper that reports this interaction (PMID 11439183)
113

Data Source:
HPRD (in vitro, in vivo)

		PPP3R1	PPP3CA
Gene Name		protein phosphatase 3, regulatory subunit B, alpha	protein phosphatase 3, catalytic subunit, alpha isozyme
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Calcineurin Complex Sarcolemma	Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcineurin Complex Z Disc Sarcolemma
	Molecular Function	Calcium-dependent Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Protein Domain Specific Binding	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	Apoptotic Process Dephosphorylation Calcineurin-NFAT Signaling Cascade Fc-epsilon Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of NFAT Protein Import Into Nucleus Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Response To Amphetamine Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Transition Between Fast And Slow Fiber Dephosphorylation Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Cellular Response To Drug Fc-epsilon Receptor Signaling Pathway T Cell Activation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Insulin Secretion Skeletal Muscle Fiber Development Regulation Of Synaptic Transmission Positive Regulation Of NFAT Protein Import Into Nucleus Response To Calcium Ion Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Response To Glucose Stimulus Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		Signaling by GPCR Opioid Signalling Activation of BH3-only proteins Signaling by Wnt beta-catenin independent WNT signaling Activation of BAD and translocation to mitochondria Ca2+ pathway Programmed Cell Death DARPP-32 events Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Intrinsic Pathway for Apoptosis Innate Immune System	Signaling by GPCR Ca2+ pathway Opioid Signalling DARPP-32 events Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Signaling by Wnt Innate Immune System beta-catenin independent WNT signaling
Drugs		MYRISTIC ACID
Diseases
GWAS			Blood pressure ( 22763476) Corneal structure ( 21979947)
Protein-Protein Interactions		8 interactors: CABP1 CABP2 CABP5 MAP3K5 NAP1L2 NFATC1 NFATC2 PPP3CA	24 interactors: AKAP5 ATP2B4 BAD BCL2 C16orf74 CABIN1 CASP3 CRTC2 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 KCNIP3 MARCH7 MYOZ2 MYOZ3 PPP3R1 PRKCZ RCAN1 RCAN2 SOD1 SYNJ1
Entrez ID		5534	5530
HPRD ID		03195	00234
Ensembl ID		ENSG00000221823	ENSG00000138814
Uniprot IDs		D3YTA9 P63098	Q08209
PDB IDs		1AUI 1M63 1MF8 2P6B 3LL8 4F0Z	1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z
Enriched GO Terms of Interacting Partners?		Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Transition Between Fast And Slow Fiber Negative Regulation Of Cell Communication By Electrical Coupling Immune Response-regulating Signaling Pathway Immune Response Defense Response Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Histone H3-K14 Acetylation Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Histone H3-K14 Acetylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Transport Regulation Of Protein Localization To Nucleus Calcineurin-NFAT Signaling Cascade Negative Regulation Of Voltage-gated Calcium Channel Activity Signal Transduction Regulation Of Nucleocytoplasmic Transport Regulation Of Stem Cell Division Regulation Of Skeletal Muscle Adaptation Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Metabolic Process Regulation Of Immune Response Positive Regulation Of NFAT Protein Import Into Nucleus Mitotic Cell Cycle Phase Transition Signaling Cell Cycle Phase Transition Regulation Of Intracellular Protein Transport Cell Communication Immune System Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Regulation Of Histone H3-K9 Acetylation Regulation Of Cell Communication By Electrical Coupling Calcium Ion Transport Inositol Phosphate-mediated Signaling Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Skeletal Muscle Fiber Development Negative Regulation Of Transport Regulation Of Immune System Process Cellular Response To Stimulus Positive Regulation Of Histone Acetylation Positive Regulation Of Transcription, DNA-templated	Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Signaling Cell Communication Behavior Cellular Response To Histamine Synaptic Transmission, GABAergic Response To Organic Cyclic Compound Calcineurin-NFAT Signaling Cascade Response To Histamine Single-organism Behavior Regulation Of Neuron Death Cellular Response To Stimulus Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Signal Transduction Inositol Phosphate-mediated Signaling Cellular Response To Ammonium Ion Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Organic Cyclic Compound Response To Oxidative Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Gamma-aminobutyric Acid Signaling Pathway Regulation Of Cell Activation Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Neurological System Process Positive Regulation Of Cellular Metabolic Process Regulation Of T Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Stimulus Synaptic Transmission Negative Regulation Of Apoptotic Process Cell-cell Signaling Regulation Of Immune System Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Phosphorylation Negative Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Transport Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Death
Tagcloud ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	adenocarcinoma chip coding cre dt ductal fresh g12d intraepithelial kras lincrna1611 lncrnas lsl neoplasia operation pan pancreatic panin pca pdac pdx profilings r172h resected rnas sh tissues tp53 weak
Tagcloud (Difference) ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	adenocarcinoma chip coding cre dt ductal fresh g12d intraepithelial kras lincrna1611 lncrnas lsl neoplasia operation pan pancreatic panin pca pdac pdx profilings r172h resected rnas sh tissues tp53 weak
Tagcloud (Intersection) ?