PPP3R1 and NFATC2

Number of citations of the paper that reports this interaction (PMID 16473827)
21

Data Source:
HPRD (in vivo)

		PPP3R1	NFATC2
Gene Name		protein phosphatase 3, regulatory subunit B, alpha	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Calcineurin Complex Sarcolemma	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Ribonucleoprotein Complex Nuclear Transcription Factor Complex
	Molecular Function	Calcium-dependent Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Protein Domain Specific Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Apoptotic Process Dephosphorylation Calcineurin-NFAT Signaling Cascade Fc-epsilon Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of NFAT Protein Import Into Nucleus Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cytokine Production Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Cell Migration Positive Regulation Of B Cell Proliferation Fc-epsilon Receptor Signaling Pathway Response To Drug Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter B Cell Receptor Signaling Pathway
Pathways		Signaling by GPCR Opioid Signalling Activation of BH3-only proteins Signaling by Wnt beta-catenin independent WNT signaling Activation of BAD and translocation to mitochondria Ca2+ pathway Programmed Cell Death DARPP-32 events Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Intrinsic Pathway for Apoptosis Innate Immune System	Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System
Drugs		MYRISTIC ACID
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CABP1 CABP2 CABP5 MAP3K5 NAP1L2 NFATC1 NFATC2 PPP3CA	19 interactors: CREBBP EGR1 EGR4 EP300 FOXP3 IRF2BP2 IRF4 JUN MED31 MEF2D NFATC2IP PIN1 PPP3CB PPP3R1 PRKCZ TAF9 VIM YWHAQ YWHAZ
Entrez ID		5534	4773
HPRD ID		03195	02730
Ensembl ID		ENSG00000221823	ENSG00000101096
Uniprot IDs		D3YTA9 P63098	B5B2P0 B5B2P2 B5B2P3 B5B2P4 Q13469
PDB IDs		1AUI 1M63 1MF8 2P6B 3LL8 4F0Z	1A02 1OWR 1P7H 1PZU 1S9K 2AS5 2O93 3QRF
Enriched GO Terms of Interacting Partners?		Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Transition Between Fast And Slow Fiber Negative Regulation Of Cell Communication By Electrical Coupling Immune Response-regulating Signaling Pathway Immune Response Defense Response Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Histone H3-K14 Acetylation Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Histone H3-K14 Acetylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Transport Regulation Of Protein Localization To Nucleus Calcineurin-NFAT Signaling Cascade Negative Regulation Of Voltage-gated Calcium Channel Activity Signal Transduction Regulation Of Nucleocytoplasmic Transport Regulation Of Stem Cell Division Regulation Of Skeletal Muscle Adaptation Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Metabolic Process Regulation Of Immune Response Positive Regulation Of NFAT Protein Import Into Nucleus Mitotic Cell Cycle Phase Transition Signaling Cell Cycle Phase Transition Regulation Of Intracellular Protein Transport Cell Communication Immune System Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Regulation Of Histone H3-K9 Acetylation Regulation Of Cell Communication By Electrical Coupling Calcium Ion Transport Inositol Phosphate-mediated Signaling Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Skeletal Muscle Fiber Development Negative Regulation Of Transport Regulation Of Immune System Process Cellular Response To Stimulus Positive Regulation Of Histone Acetylation Positive Regulation Of Transcription, DNA-templated	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Immune Response Regulation Of Metabolic Process Defense Response Innate Immune Response Positive Regulation Of Interleukin-4 Production Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Signaling Cell Activation Regulation Of Interleukin-4 Production Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Leukocyte Activation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Immune System Process Regulation Of Signal Transduction Gene Expression Regulation Of CD4-positive, Alpha-beta T Cell Differentiation N-terminal Peptidyl-lysine Acetylation Histone Acetylation Regulation Of Cellular Process Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Regulation Of Cytokine Production Internal Protein Amino Acid Acetylation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Acetylation Leukocyte Differentiation Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Apoptotic Process Apoptotic Signaling Pathway T Cell Differentiation Positive Regulation Of Cytokine Production RNA Metabolic Process Regulation Of Apoptotic Process
Tagcloud ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	calcineurin deacetylases directs eliminating erk glp hat hdac hdac3 hdacs import inhibiting interfering islet islets jnk knocking mapks p38 pancreatic preserving promoters repressed selectively stability suppressing switch tnf
Tagcloud (Difference) ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	calcineurin deacetylases directs eliminating erk glp hat hdac hdac3 hdacs import inhibiting interfering islet islets jnk knocking mapks p38 pancreatic preserving promoters repressed selectively stability suppressing switch tnf
Tagcloud (Intersection) ?