PPP3R1 and NFATC1

Number of citations of the paper that reports this interaction (PMID 16473827)
21

Data Source:
HPRD (in vivo)

		PPP3R1	NFATC1
Gene Name		protein phosphatase 3, regulatory subunit B, alpha	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Calcineurin Complex Sarcolemma	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol
	Molecular Function	Calcium-dependent Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Protein Domain Specific Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding FK506 Binding Transcription Regulatory Region DNA Binding Mitogen-activated Protein Kinase P38 Binding
	Biological Process	Apoptotic Process Dephosphorylation Calcineurin-NFAT Signaling Cascade Fc-epsilon Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of NFAT Protein Import Into Nucleus Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Epithelial To Mesenchymal Transition Transcription From RNA Polymerase II Promoter Calcium Ion Transport Heart Development Osteoclast Differentiation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Signaling by GPCR Opioid Signalling Activation of BH3-only proteins Signaling by Wnt beta-catenin independent WNT signaling Activation of BAD and translocation to mitochondria Ca2+ pathway Programmed Cell Death DARPP-32 events Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Intrinsic Pathway for Apoptosis Innate Immune System	Ca2+ pathway Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Signaling by Wnt Innate Immune System beta-catenin independent WNT signaling
Drugs		MYRISTIC ACID
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CABP1 CABP2 CABP5 MAP3K5 NAP1L2 NFATC1 NFATC2 PPP3CA	16 interactors: EGR1 EGR2 EP300 GNB2L1 HDAC5 KAT2B KPNB1 MAPK14 PARP1 PIAS1 PIM1 PPP3R1 PRKCA SPI1 TUBA1A YWHAQ
Entrez ID		5534	4772
HPRD ID		03195	02729
Ensembl ID		ENSG00000221823	ENSG00000131196
Uniprot IDs		D3YTA9 P63098	A8K9C6 B4DER8 F5H4S8 O95644
PDB IDs		1AUI 1M63 1MF8 2P6B 3LL8 4F0Z	1A66 1NFA
Enriched GO Terms of Interacting Partners?		Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Transition Between Fast And Slow Fiber Negative Regulation Of Cell Communication By Electrical Coupling Immune Response-regulating Signaling Pathway Immune Response Defense Response Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Histone H3-K14 Acetylation Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Histone H3-K14 Acetylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Transport Regulation Of Protein Localization To Nucleus Calcineurin-NFAT Signaling Cascade Negative Regulation Of Voltage-gated Calcium Channel Activity Signal Transduction Regulation Of Nucleocytoplasmic Transport Regulation Of Stem Cell Division Regulation Of Skeletal Muscle Adaptation Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Metabolic Process Regulation Of Immune Response Positive Regulation Of NFAT Protein Import Into Nucleus Mitotic Cell Cycle Phase Transition Signaling Cell Cycle Phase Transition Regulation Of Intracellular Protein Transport Cell Communication Immune System Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Regulation Of Histone H3-K9 Acetylation Regulation Of Cell Communication By Electrical Coupling Calcium Ion Transport Inositol Phosphate-mediated Signaling Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Skeletal Muscle Fiber Development Negative Regulation Of Transport Regulation Of Immune System Process Cellular Response To Stimulus Positive Regulation Of Histone Acetylation Positive Regulation Of Transcription, DNA-templated	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Death Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Response To Peptide Peptidyl-lysine Modification Negative Regulation Of Gene Expression Response To Insulin Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription N-terminal Peptidyl-lysine Acetylation Regulation Of RNA Biosynthetic Process Peptidyl-amino Acid Modification Rhythmic Process Regulation Of RNA Metabolic Process Skeletal Muscle Tissue Development Leukocyte Differentiation Skeletal Muscle Organ Development Immune System Process Regulation Of Protein Metabolic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Histone Modification Regulation Of Signaling Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway RNA Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Regulation Of Protein Localization Innate Immune Response
Tagcloud ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	124a aia ameliorated analogue ankle arthritis ccaat destruction freund hind histopathology incomplete injecting itgb1 killed leucocyte lewis luciferase micrornas mir osteoclasts prerequisites rankl raw264 rheumatoid rnas synoviocyte tartrate utr
Tagcloud (Difference) ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	124a aia ameliorated analogue ankle arthritis ccaat destruction freund hind histopathology incomplete injecting itgb1 killed leucocyte lewis luciferase micrornas mir osteoclasts prerequisites rankl raw264 rheumatoid rnas synoviocyte tartrate utr
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