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SHFL and SPRY2
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
SHFL
SPRY2
Description
shiftless antiviral inhibitor of ribosomal frameshifting
sprouty RTK signaling antagonist 2
Image
No pdb structure
GO Annotations
Cellular Component
P-body
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Microtubule
Plasma Membrane
Actin Cytoskeleton
Microtubule Cytoskeleton
Membrane
Ruffle Membrane
Cell Projection
Microtubule End
Molecular Function
RNA Binding
Protein Binding
Identical Protein Binding
Ribosome Binding
Sequence-specific MRNA Binding
Protein Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Protein Serine/threonine Kinase Activator Activity
Ubiquitin-protein Transferase Inhibitor Activity
Molecular Function Inhibitor Activity
Biological Process
Regulation Of Translational Termination
Response To Type I Interferon
Response To Type II Interferon
Response To Type III Interferon
Response To Interferon-beta
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Defense Response To Virus
Viral Translational Frameshifting
Negative Regulation Of Translational Frameshifting
Establishment Of Mitotic Spindle Orientation
Sensory Perception Of Sound
Negative Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Gene Expression
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Angiogenesis
Lung Development
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Projection Organization
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Cell Fate Commitment
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Ras Protein Signal Transduction
Animal Organ Development
Branching Morphogenesis Of An Epithelial Tube
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Lung Morphogenesis
Lung Growth
Bud Elongation Involved In Lung Branching
Respiratory System Development
ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Lens Fiber Cell Differentiation
Cellular Response To Leukemia Inhibitory Factor
Pathways
Spry regulation of FGF signaling
EGFR downregulation
Drugs
Diseases
GWAS
Adiposity (
21706003
)
Adventurousness (
30643258
)
Body fat percentage (
26833246
)
Central corneal thickness (
32528159
)
Diastolic blood pressure (
30224653
)
Fasting blood insulin (BMI interaction) (
22581228
)
General risk tolerance (MTAG) (
30643258
)
Height (
25282103
31562340
)
Insulin-related traits (multivariate analysis) (
32002517
)
Lactose tolerance test (
31791255
)
Leisure-time exercise behaviour (age-stratified) (
30102679
)
Medication use (drugs used in diabetes) (
31015401
)
Methadone dose in opioid dependence (
28115739
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Orofacial clefts (
20023658
22863734
)
Response to inhaled corticosteroid treatment in asthma (change in FEV1) (
24792382
)
Sleep duration (
25469926
)
Thrombocytopenia in coronary artery bypass surgery (
30103242
)
Type 2 diabetes (
29358691
30718926
32499647
31118516
30297969
30054458
28869590
26818947
24509480
22885922
20862305
)
Venous thromboembolism adjusted for sickle cell variant rs77121243-T (
28203683
)
Interacting Genes
65 interacting genes:
ADAMTSL4
CADPS
CCDC136
CCNDBP1
CYSRT1
DRICH1
DTNBP1
DVL3
FHL5
HSF2BP
IKZF1
INCA1
KLF15
KRT31
KRT40
KRTAP1-1
KRTAP1-3
KRTAP1-5
KRTAP10-1
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-3
KRTAP17-1
KRTAP2-3
KRTAP2-4
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP5-7
KRTAP5-9
KRTAP9-2
KRTAP9-3
LNX1
LURAP1
LZTS2
MAGEA1
MDFI
MEOX2
MID2
MTUS2
NBPF19
NOTCH2NLA
PCSK5
PDE4DIP
PICK1
PPP2R5A
SPRY2
SSX2IP
TCF4
TENM4
TERF1
TLE5
TNS2
TRAF1
TRIB3
TRIM42
TRIM55
TRIM63
VWC2
ZNF835
110 interacting genes:
ADAMTSL4
AQP1
ATRIP
BAG3
BRAF
CATSPER1
CBL
CBLB
CBLC
CHRD
CHRNG
CREB5
CRIP2
CRMP1
CSTB
CTSB
DGCR6
DNM2
DSCR9
DYRK1A
EIF4E2
FAIM
FAM219A
FBN1
FBXO7
FRS3
FXR1
FXR2
GNE
GP9
GPRIN2
GRAP2
GRB2
GRN
HEXIM2
HNRNPLL
HOXA1
HSD3B7
ITSN1
KDM1A
KIF1A
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LASP1
LCE1A
LCE1B
LCE1C
LCE1F
LCE2D
LCE3C
LCE3E
LCE4A
LONRF1
MAPKBP1
MB21D2
MDFI
MEOX2
MID2
MKNK1
MLLT6
NCK2
NEDD4
NR1H2
NUBP1
NUFIP2
OTX1
PACSIN3
PLSCR1
PRKAB2
PRKCD
PRKD1
PTGER3
PTPN11
RAF1
RTF2
RUNX1T1
SDHB
SEMA5B
SH3KBP1
SHFL
SIAH2
SPRY1
STK16
TCAF1
TMEM14B
TNS2
TRAF2
TRIM51
TXNDC5
UBASH3A
UBASH3B
UBR1
USP20
VPS25
VPS36
ZBTB16
ZNF266
ZNF417
ZNF587
Entrez ID
55337
10253
HPRD ID
07747
03916
Ensembl ID
ENSG00000130813
ENSG00000136158
Uniprot IDs
Q9NUL5
O43597
PDB IDs
3BUM
3OB1
5HKY
5HKZ
5HL0
Enriched GO Terms of Interacting Partners
?
Intermediate Filament
Keratin Filament
Hair Cycle
Identical Protein Binding
Cytosol
Protein Binding
Interstitial Matrix
Intermediate Filament
Keratin Filament
Keratinization
Phosphotyrosine Residue Binding
Identical Protein Binding
Epidermis Development
Negative Regulation Of Signal Transduction
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Binding
Cytosol
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Receptor Tyrosine Kinase Binding
SH3 Domain Binding
Regulation Of Signal Transduction
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
ESCRT II Complex
ERBB Signaling Pathway
Tissue Development
Ubiquitin-protein Transferase Activity
Regulation Of Cell Activation
Regulation Of Biological Quality
Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Zinc Ion Binding
Ubiquitin Protein Ligase Activity
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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