SHFL and FHL5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SHFL	FHL5
Description		shiftless antiviral inhibitor of ribosomal frameshifting	four and a half LIM domains 5
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Z Disc
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding Ribosome Binding Sequence-specific MRNA Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of Translational Termination Response To Type I Interferon Response To Type II Interferon Response To Type III Interferon Response To Interferon-beta Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Viral Translational Frameshifting Negative Regulation Of Translational Frameshifting	Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS			Cerebral blood flow ( 28627999) Cluster headache ( 34184781) Coronary artery disease ( 29212778) Coronary heart disease ( 22319020) Headache ( 29397368) Metabolite levels ( 23823483) Migraine ( 27322543 27182965 23793025 22683712) Migraine - clinic-based ( 23793025) Migraine without aura ( 27322543 23793025) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) Pulse pressure ( 30578418) Spatial memory ( 31596458)
Interacting Genes		65 interacting genes: ADAMTSL4 CADPS CCDC136 CCNDBP1 CYSRT1 DRICH1 DTNBP1 DVL3 FHL5 HSF2BP IKZF1 INCA1 KLF15 KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 LNX1 LURAP1 LZTS2 MAGEA1 MDFI MEOX2 MID2 MTUS2 NBPF19 NOTCH2NLA PCSK5 PDE4DIP PICK1 PPP2R5A SPRY2 SSX2IP TCF4 TENM4 TERF1 TLE5 TNS2 TRAF1 TRIB3 TRIM42 TRIM55 TRIM63 VWC2 ZNF835	89 interacting genes: ABI2 ADAM12 ADAMTSL5 AGXT ANKRD55 ANKS1A ATOSB BANP BBC3 BCL6B CATSPER1 CDC20B CFP CNNM3 COIL CREB1 CREM CRYBA2 CRYBA4 CTSZ DCDC2B DLGAP4 DMRT3 DNAL4 DTX2 FARS2 FEZF1 FHL2 GARIN6 GPS2 GSTP1 HAPLN2 HCK HDX HEY2 HOXA1 HOXB9 IL16 IP6K3 KIF17 KIR2DL4 LMO2 LRRC41 MAGOHB MISP MYOZ3 NEK6 NPDC1 NUFIP2 OTX1 PIN1 PLEKHA2 PLEKHN1 PPP1R18 QRICH1 RAB26 RAB3IL1 RPS21 SAXO1 SAXO4 SCNM1 SDCBP SEC31A SHFL SLIT1 SMAD1 SPRY1 SRF TUSC2 TXN2 YPEL3 ZBTB16 ZNF124 ZNF23 ZNF250 ZNF251 ZNF408 ZNF417 ZNF440 ZNF446 ZNF564 ZNF581 ZNF587 ZNF613 ZNF688 ZNF764 ZNF766 ZNF792 ZNHIT1
Entrez ID		55337	9457
HPRD ID		07747	05497
Ensembl ID		ENSG00000130813	ENSG00000112214
Uniprot IDs		Q9NUL5	Q5TD97
PDB IDs			1X68
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Hair Cycle Identical Protein Binding Cytosol Protein Binding Interstitial Matrix	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Nucleus Heart Trabecula Formation Regulation Of Primary Metabolic Process Identical Protein Binding Regulation Of Macromolecule Metabolic Process Zinc Ion Binding ATF4-CREB1 Transcription Factor Complex Regulation Of Metabolic Process Tangential Migration From The Subventricular Zone To The Olfactory Bulb
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