FBXW7 and CREB3L1

Number of citations of the paper that reports this interaction (PMID 8051045)
1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		FBXW7	CREB3L1
Gene Name		F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	cAMP responsive element binding protein 3-like 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Golgi Apparatus SCF Ubiquitin Ligase Complex Protein Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Cyclin Binding Protein Binding, Bridging Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin-protein Transferase Activator Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding CAMP Response Element Binding Sequence-specific DNA Binding
	Biological Process	Vasculogenesis Vasculature Development Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Sister Chromatid Cohesion Notch Signaling Pathway Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Viral Process Protein Ubiquitination Lung Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA Endoreduplication Regulation Of Protein Localization Cellular Response To UV Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Notch Signaling Pathway Protein Stabilization Positive Regulation Of Ubiquitin-protein Transferase Activity Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway	Transcription, DNA-templated Regulation Of Bone Mineralization Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Protein folding Antigen processing: Ubiquitination & Proteasome degradation Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ARL6IP1 CCNE1 CCNE2 CDC34 CREB3L1 CREB3L2 CUL1 EBNA1BP2 FAM101A GLMN GNB2L1 HEY1 HIPK2 JUN KIAA1875 KLF5 LINGO1 MCL1 MED13 MED13L MMS22L MYB MYC NOTCH1 NOTCH4 PARK2 PPARGC1A PSEN1 SHPRH SKP1 STOML1 SUMF2 UBE2D1	23 interactors: C5 CREB3 CREB3L3 CREM DDIT3 FAM3C FBXW7 FXYD6 GPR25 JAGN1 MFSD5 NRM PGRMC1 PRKAB2 RUNX1T1 SLC30A8 SLC35B4 TMEM147 TMEM218 TMEM234 TSPO UBA1 UBE2D3
Entrez ID		55294	90993
HPRD ID		05888	16751
Ensembl ID		ENSG00000109670	ENSG00000157613
Uniprot IDs		B7Z2C8 G0Z2K0 Q969H0 S4R3U4	B2RA75 Q96BA8
PDB IDs		2OVP 2OVQ 2OVR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Notch Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Neuron Death Cellular Response To Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Proteolysis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Response To Organic Substance Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Regulation Of Protein Ubiquitination Negative Regulation Of Neuron Death Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Cellular Response To Stimulus Positive Regulation Of Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Death Cell Cycle Phase Transition Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Gene Expression	Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Response To Organic Substance ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Cellular Response To Stress Response To Stress Response To Unfolded Protein Regulation Of Lipid Biosynthetic Process Regulation Of Ion Homeostasis Response To Endoplasmic Reticulum Stress Ion Transport Negative Regulation Of Cell Cycle Signaling Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Cell Communication Modification-dependent Protein Catabolic Process Regulation Of Cytokine Production Negative Regulation Of Determination Of Dorsal Identity Negative Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Negative Regulation Of SREBP Signaling Pathway Granulocyte Colony-stimulating Factor Signaling Pathway UDP-xylose Transport Molybdate Ion Transport Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Cellular Metabolic Process Cellular Protein Catabolic Process Response To Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Signal Transduction Proteasomal Protein Catabolic Process Inorganic Anion Transport Protein Catabolic Process Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Macrophage Chemotaxis UDP-N-acetylglucosamine Transport Release From Viral Latency Regulation Of Transcription Involved In Anterior/posterior Axis Specification UDP-N-acetylglucosamine Transmembrane Transport Regulation Of Lipid Metabolic Process Positive Regulation Of Neuron Death Anion Transport Cellular Response To Stimulus Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Neutrophil Differentiation Response To Vitamin B1
Tagcloud ?		bcl11b cadherin discovered dnm2 druggable exhibitedthe fat1 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2	aggressive bladder candidate clearly colony downregulation hence highlights htra3 hypermethylation immunohistochemical interestingly invasive j82 mediates nuclei potentially predominately proposed public putative pyrosequencing set suppression suppressor tgf tissues verified
Tagcloud (Difference) ?		bcl11b cadherin discovered dnm2 druggable exhibitedthe fat1 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2	aggressive bladder candidate clearly colony downregulation hence highlights htra3 hypermethylation immunohistochemical interestingly invasive j82 mediates nuclei potentially predominately proposed public putative pyrosequencing set suppression suppressor tgf tissues verified
Tagcloud (Intersection) ?