CREB3L1 and C5

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CREB3L1	C5
Gene Name		cAMP responsive element binding protein 3-like 1	complement component 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Extracellular Region Membrane Attack Complex Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding CAMP Response Element Binding Sequence-specific DNA Binding	Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Chemokine Activity C5a Anaphylatoxin Chemotactic Receptor Binding
	Biological Process	Transcription, DNA-templated Regulation Of Bone Mineralization Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter	Activation Of MAPK Activity In Utero Embryonic Development Leukocyte Migration Involved In Inflammatory Response Cellular Calcium Ion Homeostasis Chemotaxis Response To Stress Inflammatory Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Negative Regulation Of Norepinephrine Secretion Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Endopeptidase Activity Cytolysis Regulation Of Complement Activation Negative Regulation Of Dopamine Secretion Glucose Homeostasis Innate Immune Response Positive Regulation Of Angiogenesis Positive Regulation Of Chemotaxis Cell Chemotaxis Positive Regulation Of Chemokine Secretion
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Activation of C3 and C5 Terminal pathway of complement Metabolic disorders of biological oxidation enzymes GPCR ligand binding GPCR downstream signaling Regulation of Complement cascade Peptide ligand-binding receptors Complement cascade G alpha (i) signalling events Innate Immune System
Drugs			Intravenous Immunoglobulin Eculizumab
Diseases
GWAS			Rheumatoid arthritis ( 20453842 19503088)
Protein-Protein Interactions		23 interactors: C5 CREB3 CREB3L3 CREM DDIT3 FAM3C FBXW7 FXYD6 GPR25 JAGN1 MFSD5 NRM PGRMC1 PRKAB2 RUNX1T1 SLC30A8 SLC35B4 TMEM147 TMEM218 TMEM234 TSPO UBA1 UBE2D3	9 interactors: C2 C3 C5AR1 C6 C7 C8B CPB2 CPN1 CREB3L1
Entrez ID		90993	727
HPRD ID		16751	00405
Ensembl ID		ENSG00000157613	ENSG00000106804
Uniprot IDs		B2RA75 Q96BA8	P01031
PDB IDs			1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Response To Organic Substance ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Cellular Response To Stress Response To Stress Response To Unfolded Protein Regulation Of Lipid Biosynthetic Process Regulation Of Ion Homeostasis Response To Endoplasmic Reticulum Stress Ion Transport Negative Regulation Of Cell Cycle Signaling Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Cell Communication Modification-dependent Protein Catabolic Process Regulation Of Cytokine Production Negative Regulation Of Determination Of Dorsal Identity Negative Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Negative Regulation Of SREBP Signaling Pathway Granulocyte Colony-stimulating Factor Signaling Pathway UDP-xylose Transport Molybdate Ion Transport Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Cellular Metabolic Process Cellular Protein Catabolic Process Response To Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Signal Transduction Proteasomal Protein Catabolic Process Inorganic Anion Transport Protein Catabolic Process Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Macrophage Chemotaxis UDP-N-acetylglucosamine Transport Release From Viral Latency Regulation Of Transcription Involved In Anterior/posterior Axis Specification UDP-N-acetylglucosamine Transmembrane Transport Regulation Of Lipid Metabolic Process Positive Regulation Of Neuron Death Anion Transport Cellular Response To Stimulus Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Neutrophil Differentiation Response To Vitamin B1	Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Regulation Of Protein Processing Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Complement Activation, Alternative Pathway Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Inflammatory Response Positive Regulation Of Immune Response Cytolysis Positive Regulation Of Activation Of Membrane Attack Complex Regulation Of Immune Response Positive Regulation Of Immune System Process Response To Stress Regulation Of Protein Metabolic Process Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Apoptotic Cell Clearance Innate Immune Response Regulation Of Apoptotic Cell Clearance Positive Regulation Of Humoral Immune Response Positive Regulation Of Protein Processing Immune System Process Response To Stimulus Positive Regulation Of Phagocytosis Regulation Of Phagocytosis Organ Regeneration Complement Component C5a Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Endocytosis Positive Regulation Of Type IIa Hypersensitivity Protein Metabolic Process Cellular Chemical Homeostasis Positive Regulation Of Angiogenesis Positive Regulation Of Extracellular Matrix Constituent Secretion Negative Regulation Of Hepatocyte Proliferation Liver Regeneration Bradykinin Catabolic Process Cell Proliferation In Hindbrain Complement Receptor Mediated Signaling Pathway Cellular Homeostasis
Tagcloud ?		aggressive bladder candidate clearly colony downregulation hence highlights htra3 hypermethylation immunohistochemical interestingly invasive j82 mediates nuclei potentially predominately proposed public putative pyrosequencing set suppression suppressor tgf tissues verified	autophosphorylation cleavage cleave cleaved convertases d4 endoproteolytic exclude furin greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive
Tagcloud (Difference) ?		aggressive bladder candidate clearly colony downregulation hence highlights htra3 hypermethylation immunohistochemical interestingly invasive j82 mediates nuclei potentially predominately proposed public putative pyrosequencing set suppression suppressor tgf tissues verified	autophosphorylation cleavage cleave cleaved convertases d4 endoproteolytic exclude furin greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive
Tagcloud (Intersection) ?