TLK1 and MBP

Number of citations of the paper that reports this interaction (PMID 10523312)
32

Data Source:
HPRD (in vitro)

		TLK1	MBP
Gene Name		tousled-like kinase 1	myelin basic protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Plasma Membrane Internode Region Of Axon Neuronal Cell Body Compact Myelin
	Molecular Function	Protein Serine/threonine Kinase Activity ATP Binding	Protease Binding Protein Binding Structural Constituent Of Myelin Sheath
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Protein Phosphorylation Intracellular Protein Transport Cellular Response To DNA Damage Stimulus Cell Cycle Chromatin Modification Intracellular Signal Transduction	Immune Response Synaptic Transmission Central Nervous System Development Aging Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Response To Progesterone Response To Tumor Necrosis Factor Myelination Response To Mercury Ion Negative Regulation Of Axonogenesis Membrane Organization Response To Fatty Acid
Pathways
Drugs
Diseases
GWAS		Menopause (age at onset) ( 22267201)	Age-related macular degeneration (GA) ( 22705344)
Protein-Protein Interactions		13 interactors: ASF1A ASF1B AURKA CHEK1 HIST1H1A LUZP4 MBP NBN SNAP23 TLK2 TPM3 UBE3C YWHAE	72 interactors: ABL1 APTX ATN1 ATXN1 BMP2K CCNC CCNH CCNT1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 DYRK1B HIPK2 HLA-DRA IKBKE IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPKAPK5 MELK MICU2 MKNK1 MMP7 MNAT1 NEK9 PAK1 PKN1 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSSK6 ULK1
Entrez ID		9874	4155
HPRD ID		12232	01158
Ensembl ID		ENSG00000198586	ENSG00000197971
Uniprot IDs		Q9UKI8	P02686
PDB IDs			1BX2 1FV1 1HQR 1QCL 1YMM 1ZGL
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Organization Organelle Organization Chromatin Modification DNA Conformation Change DNA Replication-dependent Nucleosome Assembly Positive Regulation Of Gene Expression, Epigenetic G2/M Transition Of Mitotic Cell Cycle Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Protein Complex Assembly DNA Packaging Histone Phosphorylation DNA Replication-independent Nucleosome Assembly G2 DNA Damage Checkpoint Substantia Nigra Development Cellular Macromolecular Complex Assembly Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle Phase Transition Regulation Of Centrosome Cycle Cell Cycle Neural Nucleus Development Mitotic Cell Cycle Response To Stress Negative Regulation Of Spindle Checkpoint Cellular Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Organelle Organization Midbrain Development Regulation Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Spindle Assembly Involved In Female Meiosis I Regulation Of Heart Rate By Hormone Histone H3-T11 Phosphorylation Negative Regulation Of Peptidyl-serine Dephosphorylation Negative Regulation Of Cell Cycle Cell Cycle Process Reproduction Defense Response To Nematode Spindle Assembly Involved In Meiosis Peptidyl-serine Phosphorylation Cellular Component Assembly Regulation Of Cellular Component Organization Regulation Of Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Spindle Stabilization	Protein Phosphorylation Phosphorylation Phosphate-containing Compound Metabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Intracellular Signal Transduction Regulation Of Protein Phosphorylation Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Signal Transduction By Phosphorylation Protein Autophosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Protein Kinase Activity Peptidyl-threonine Phosphorylation Cellular Response To Growth Factor Stimulus Peptidyl-amino Acid Modification Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway MAPK Cascade Cellular Response To Stress Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Signaling Neurotrophin TRK Receptor Signaling Pathway Cell Communication Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Response To Stimulus Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Death Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Metabolic Process Response To Stimulus Regulation Of MAP Kinase Activity Apoptotic Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process
Tagcloud ?		asymmetric belonging cloned coefficient crystallization crystals cubic diffracting diffraction evolutionarily hetero homo homogeneity i4122 localize matthews namely oligomers p213 purification segregation solvent synchrotron tetragonal threonine tlk2 tlks tousled yielded	ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mst1 mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad
Tagcloud (Difference) ?		asymmetric belonging cloned coefficient crystallization crystals cubic diffracting diffraction evolutionarily hetero homo homogeneity i4122 localize matthews namely oligomers p213 purification segregation solvent synchrotron tetragonal threonine tlk2 tlks tousled yielded	ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mst1 mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad
Tagcloud (Intersection) ?