TLK1 and NBN

Number of citations of the paper that reports this interaction (PMID 12955071)
18

Data Source:
BioGRID (enzymatic study)

		TLK1	NBN
Gene Name		tousled-like kinase 1	nibrin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Nucleolus PML Body Mre11 Complex Site Of Double-strand Break Nuclear Inclusion Body
	Molecular Function	Protein Serine/threonine Kinase Activity ATP Binding	Damaged DNA Binding ATP-dependent DNA Helicase Activity Protein Binding Transcription Factor Binding Protein N-terminus Binding
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Protein Phosphorylation Intracellular Protein Transport Cellular Response To DNA Damage Stimulus Cell Cycle Chromatin Modification Intracellular Signal Transduction	DNA Damage Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Blastocyst Growth DNA Repair Double-strand Break Repair Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Mitotic G2 DNA Damage Checkpoint Cell Proliferation Regulation Of DNA-dependent DNA Replication Initiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Autophosphorylation DNA Duplex Unwinding Positive Regulation Of Kinase Activity Isotype Switching Neuromuscular Process Controlling Balance Meiotic Cell Cycle Intrinsic Apoptotic Signaling Pathway
Pathways			ATM mediated phosphorylation of repair proteins Meiotic recombination DNA Damage/Telomere Stress Induced Senescence MRN complex relocalizes to nuclear foci ATM mediated response to DNA double-strand break Cellular Senescence Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks Homologous Recombination Repair Recruitment of repair and signaling proteins to double-strand breaks Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS		Menopause (age at onset) ( 22267201)
Protein-Protein Interactions		13 interactors: ASF1A ASF1B AURKA CHEK1 HIST1H1A LUZP4 MBP NBN SNAP23 TLK2 TPM3 UBE3C YWHAE	27 interactors: ATF2 ATM ATR BRCA1 CCNE1 CDK9 CHEK2 DCLRE1C EP300 FANCD2 H2AFX MDC1 MRE11A NCL PRKDC RAD18 RAD50 RECQL5 RNF8 SIRT1 TERF1 TLK1 TREX1 UBE2D1 UBE2N XRCC4 XRCC5
Entrez ID		9874	4683
HPRD ID		12232	04050
Ensembl ID		ENSG00000198586	ENSG00000104320
Uniprot IDs		Q9UKI8	O60934
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Organization Organelle Organization Chromatin Modification DNA Conformation Change DNA Replication-dependent Nucleosome Assembly Positive Regulation Of Gene Expression, Epigenetic G2/M Transition Of Mitotic Cell Cycle Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Protein Complex Assembly DNA Packaging Histone Phosphorylation DNA Replication-independent Nucleosome Assembly G2 DNA Damage Checkpoint Substantia Nigra Development Cellular Macromolecular Complex Assembly Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle Phase Transition Regulation Of Centrosome Cycle Cell Cycle Neural Nucleus Development Mitotic Cell Cycle Response To Stress Negative Regulation Of Spindle Checkpoint Cellular Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Organelle Organization Midbrain Development Regulation Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Spindle Assembly Involved In Female Meiosis I Regulation Of Heart Rate By Hormone Histone H3-T11 Phosphorylation Negative Regulation Of Peptidyl-serine Dephosphorylation Negative Regulation Of Cell Cycle Cell Cycle Process Reproduction Defense Response To Nematode Spindle Assembly Involved In Meiosis Peptidyl-serine Phosphorylation Cellular Component Assembly Regulation Of Cellular Component Organization Regulation Of Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Spindle Stabilization	Cellular Response To DNA Damage Stimulus DNA Repair Cellular Response To Stress DNA Metabolic Process Double-strand Break Repair DNA Recombination Response To Ionizing Radiation Response To Stress Cell Cycle Process Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleobase-containing Compound Metabolic Process Response To Radiation Cell Cycle Checkpoint Chromosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Damage Checkpoint DNA Replication Telomere Maintenance Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Response To DNA Damage Stimulus Cellular Response To Stimulus Mitotic Cell Cycle Process Regulation Of Cell Cycle Mitotic Cell Cycle Checkpoint Mitotic Cell Cycle Organelle Organization Response To Stimulus Response To Gamma Radiation Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of DNA Repair Negative Regulation Of Mitotic Cell Cycle Intra-S DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA Repair Negative Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Negative Regulation Of DNA Replication Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process
Tagcloud ?		asymmetric belonging cloned coefficient crystallization crystals cubic diffracting diffraction evolutionarily hetero homo homogeneity i4122 localize matthews namely oligomers p213 purification segregation solvent synchrotron tetragonal threonine tlk2 tlks tousled yielded	5yrs atm atr brfr category cohorts ddr decisions fail gains gleason guided igrt mre11a nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald
Tagcloud (Difference) ?		asymmetric belonging cloned coefficient crystallization crystals cubic diffracting diffraction evolutionarily hetero homo homogeneity i4122 localize matthews namely oligomers p213 purification segregation solvent synchrotron tetragonal threonine tlk2 tlks tousled yielded	5yrs atm atr brfr category cohorts ddr decisions fail gains gleason guided igrt mre11a nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald
Tagcloud (Intersection) ?