TLK1 and ASF1B

Number of citations of the paper that reports this interaction (PMID 11470414)
52

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		TLK1	ASF1B
Gene Name		tousled-like kinase 1	anti-silencing function 1B histone chaperone
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nuclear Chromatin Nucleoplasm Protein Complex
	Molecular Function	Protein Serine/threonine Kinase Activity ATP Binding	Protein Binding Histone Binding
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Protein Phosphorylation Intracellular Protein Transport Cellular Response To DNA Damage Stimulus Cell Cycle Chromatin Modification Intracellular Signal Transduction	DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Spermatogenesis Chromatin Modification Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Menopause (age at onset) ( 22267201)
Protein-Protein Interactions		13 interactors: ASF1A ASF1B AURKA CHEK1 HIST1H1A LUZP4 MBP NBN SNAP23 TLK2 TPM3 UBE3C YWHAE	14 interactors: ASF1A C15orf41 CHAF1A CHAF1B H3F3A HCFC1 HIRA HIST1H3C HIST1H3E HIST1H4F HIST4H4 TAF1 TLK1 TLK2
Entrez ID		9874	55723
HPRD ID		12232	16460
Ensembl ID		ENSG00000198586	ENSG00000105011
Uniprot IDs		Q9UKI8	Q9NVP2
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Organization Organelle Organization Chromatin Modification DNA Conformation Change DNA Replication-dependent Nucleosome Assembly Positive Regulation Of Gene Expression, Epigenetic G2/M Transition Of Mitotic Cell Cycle Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Protein Complex Assembly DNA Packaging Histone Phosphorylation DNA Replication-independent Nucleosome Assembly G2 DNA Damage Checkpoint Substantia Nigra Development Cellular Macromolecular Complex Assembly Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle Phase Transition Regulation Of Centrosome Cycle Cell Cycle Neural Nucleus Development Mitotic Cell Cycle Response To Stress Negative Regulation Of Spindle Checkpoint Cellular Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Organelle Organization Midbrain Development Regulation Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Spindle Assembly Involved In Female Meiosis I Regulation Of Heart Rate By Hormone Histone H3-T11 Phosphorylation Negative Regulation Of Peptidyl-serine Dephosphorylation Negative Regulation Of Cell Cycle Cell Cycle Process Reproduction Defense Response To Nematode Spindle Assembly Involved In Meiosis Peptidyl-serine Phosphorylation Cellular Component Assembly Regulation Of Cellular Component Organization Regulation Of Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Spindle Stabilization	DNA Replication-dependent Nucleosome Assembly Chromatin Organization Protein-DNA Complex Assembly Nucleosome Assembly Chromosome Organization Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly DNA Packaging DNA Conformation Change DNA Methylation On Cytosine Cellular Macromolecular Complex Assembly Chromatin Silencing At RDNA Organelle Organization DNA Replication-independent Nucleosome Assembly Chromatin Silencing DNA Methylation Chromatin Modification Protein Complex Assembly Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic DNA Modification Gene Silencing Cellular Component Assembly DNA Metabolic Process Gene Expression Cell Cycle Regulation Of Gene Silencing Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone H4-K20 Demethylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Methylation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Megakaryocyte Differentiation Regulation Of Chromatin Assembly Or Disassembly Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Response To Stress
Tagcloud ?		asymmetric belonging cloned coefficient crystallization crystals cubic diffracting diffraction evolutionarily hetero homo homogeneity i4122 localize matthews namely oligomers p213 purification segregation solvent synchrotron tetragonal threonine tlk2 tlks tousled yielded	aid avenue caf cenp centromeric chaperones clustering dataset decisions discriminate distinguish exploit guide hierarchical hjurp implicating ki67 luminal offers outperforming p150 p60 regulators substratification tools transcriptome unfavorable unsupervised utilized
Tagcloud (Difference) ?		asymmetric belonging cloned coefficient crystallization crystals cubic diffracting diffraction evolutionarily hetero homo homogeneity i4122 localize matthews namely oligomers p213 purification segregation solvent synchrotron tetragonal threonine tlk2 tlks tousled yielded	aid avenue caf cenp centromeric chaperones clustering dataset decisions discriminate distinguish exploit guide hierarchical hjurp implicating ki67 luminal offers outperforming p150 p60 regulators substratification tools transcriptome unfavorable unsupervised utilized
Tagcloud (Intersection) ?