TLK1 and GPRASP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TLK1	GPRASP3
Description		tousled like kinase 1	G protein-coupled receptor associated sorting protein family member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding Protein Homodimerization Activity
	Biological Process	Chromatin Organization Protein Phosphorylation Intracellular Protein Transport DNA Damage Response Chromosome Segregation Intracellular Signal Transduction Regulation Of Chromatin Organization	Learning Or Memory Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neurogenesis Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Autism spectrum disorder ( 34069769) Health literacy ( 31250787) Liver enzyme levels (alkaline phosphatase) ( 33972514) Menopause (age at onset) ( 22267201 26414677) Platelet distribution width ( 27863252 32888494)
Interacting Genes		27 interacting genes: ASF1A ASF1B AURKA BEND7 CHEK1 DPPA4 GPRASP3 H1-1 LHX2 LUZP4 MBP NBN PAX6 PINX1 PTPN11 RAD9A SNAP23 TFCP2 TLK2 TPM3 UBE3C YAF2 YWHAE ZNF655 ZNF773 ZNF829 ZSCAN22	59 interacting genes: ANKRD11 APP AQP1 ATOSB BEX2 CATSPERT CCDC120 CDC23 CDC37 CDCA7L CT55 DDX6 DRC4 EAF1 EIF3B ENKD1 FAM124B FAM161A FAM90A1 GEM GPANK1 HOXA1 INO80B IPO5 IQUB KLHL38 L3MBTL2 LEO1 LMO1 LONRF1 MFAP1 MISP MPP1 MYO15B NRIP1 OTX1 PALS1 PHF1 PNMA5 POLR1C PPP2R5E PRKAB2 PRPF31 RCOR3 SCNM1 SH3KBP1 SMARCD1 SPANXN2 TASOR2 TCEA2 TEPSIN THOC1 TLK1 TOP3B TSGA10IP TXN2 USP2 USP20 ZNF417
Entrez ID		9874	80823
HPRD ID		12232	10028
Ensembl ID		ENSG00000198586	ENSG00000198908
Uniprot IDs		B3KRP1 Q9UKI8	Q6PI77
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Mitotic Cell Cycle Nucleus Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Chromatin Organization Chromatin Remodeling Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Signaling Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Telencephalon Regionalization Regulation Of Cell Cycle G2/M Phase Transition DNA Replication-dependent Chromatin Assembly Signal Transduction In Response To DNA Damage Negative Regulation Of Mitotic Cell Cycle Phase Transition Histone Chaperone Activity Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Cerebral Cortex Development Nucleoplasm Protein Localization To Organelle Protein Localization To Chromosome Nucleosome Assembly RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Replication Fork Protein Binding Regulation Of DNA Recombination Mitotic G2 DNA Damage Checkpoint Signaling DNA Damage Response Positive Regulation Of Mitotic Cell Cycle Protein-containing Complex Chromatin Negative Regulation Of DNA Metabolic Process DNA Binding Nucleosome Organization Positive Regulation Of Metalloendopeptidase Activity Astrocyte Differentiation Forebrain-midbrain Boundary Formation Pancreatic A Cell Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Regulation Of Protein Export From Nucleus Negative Regulation Of Telomere Maintenance
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