GMPPB

Gene Name		GDP-mannose pyrophosphorylase B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Extracellular Vesicular Exosome
	Molecular Function	Mannose-1-phosphate Guanylyltransferase Activity GTP Binding
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process GDP-mannose Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Synthesis of GDP-mannose Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS		Ulcerative colitis ( 21297633)
Protein-protein Interactions		2 interactors: GMPPA TXNDC5
Entrez ID		29925
HPRD ID		13589
Ensembl ID		ENSG00000173540
Uniprot IDs		Q9Y5P6
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?		fkrp lgmd1 lgmd1c lgmd1h lgmd2 lgmd2d lgmd2e lgmd2f lgmd2g lgmd2h lgmd2i lgmd2j lgmd2k lgmd2l lgmd2m lgmd2n lgmd2o lgmd2p lgmd2q lgmd2r lgmd2s lgmd2t lgmd2u lgmd2v lgmd2w pinch2 pomtng1 thity trappc11