GMPPB and GLYCTK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GMPPB	GLYCTK
Description		GDP-mannose pyrophosphorylase B	glycerate kinase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol GDP-mannose Pyrophosphorylase Complex	Cytoplasm Mitochondrion Golgi Apparatus Cytosol
	Molecular Function	Nucleotide Binding Mannose-1-phosphate Guanylyltransferase (GTP) Activity Protein Binding GTP Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding	Nucleotide Binding Protein Binding ATP Binding Glycerate Kinase Activity Kinase Activity Transferase Activity
	Biological Process	Protein Glycosylation GDP-mannose Biosynthetic Process GDP-mannose Metabolic Process GDP-mannose Biosynthetic Process From Mannose	Protein Phosphorylation Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate
Pathways		Synthesis of GDP-mannose	Fructose catabolism
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Multisite chronic pain ( 31194737) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Resting heart rate ( 27798624) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 21297633)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Hemoglobin levels ( 32327693) Schizophrenia ( 23974872 28991256)
Interacting Genes		5 interacting genes: DPPA4 GLYCTK GMPPA POLR1C TXNDC5	59 interacting genes: ACTMAP ADAMTSL4 ANKRD53 ARMC5 ATP23 BAIAP2L2 CALCOCO2 CEP70 DTX2 EFHC2 GMPPB GOLGA2 IHO1 KLHL12 KRT13 KRT15 KRT19 KRT34 KRT75 KRTAP19-5 KRTAP6-2 KRTAP6-3 LZTS2 MAGED1 METTL15 METTL27 MGAT5B MIS18A MORN3 NFKBID NOTO NT5C2 PFDN5 PICK1 PLAGL2 POMC PRDM14 PUDP RBCK1 RBPMS REL SAXO1 SERTAD1 SMUG1 SNF8 SPAG8 SPRED1 STK33 TRIM27 TRIM42 TRIP13 TUBGCP4 UBP1 UFSP1 ZFP90 ZG16 ZIM2 ZNF620 ZNF688
Entrez ID		29925	132158
HPRD ID		13589	13586
Ensembl ID		ENSG00000173540	ENSG00000168237
Uniprot IDs		Q9Y5P6	C9JA32 Q8IVS8
PDB IDs		7D72 7D73 7D74
Enriched GO Terms of Interacting Partners?		Molecular Sensor Activity GDP-mannose Pyrophosphorylase Complex Mannose-1-phosphate Guanylyltransferase (GTP) Activity Fructose Catabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Glycerate Kinase Activity	Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Protein Binding Cytoskeleton Cytosol Axonemal Microtubule Supramolecular Fiber Organization Structural Molecule Activity
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