GMPPB and TXNDC5

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GMPPB	TXNDC5
Gene Name		GDP-mannose pyrophosphorylase B	thioredoxin domain containing 5 (endoplasmic reticulum)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Extracellular Vesicular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Mannose-1-phosphate Guanylyltransferase Activity GTP Binding	Protein Disulfide Isomerase Activity Protein Binding
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process GDP-mannose Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process	Protein Folding Post-Golgi Vesicle-mediated Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Cell Redox Homeostasis Membrane Organization
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Synthesis of GDP-mannose Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding Lysosome Vesicle Biogenesis
Drugs
Diseases
GWAS		Ulcerative colitis ( 21297633)
Protein-Protein Interactions		2 interactors: GMPPA TXNDC5	21 interactors: ALS2CR12 APP BLZF1 EFEMP1 GMPPB KRT38 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 LHX4 MGAT5B NOTCH2NL SPRY2 TRIM23 TRIM42 TRIP6
Entrez ID		29925	81567
HPRD ID		13589	18249
Ensembl ID		ENSG00000173540	ENSG00000239264
Uniprot IDs		Q9Y5P6	Q6EHZ3 Q8NBS9
PDB IDs			2DIZ 3UJ1 3UVT
Enriched GO Terms of Interacting Partners?
Tagcloud ?		fkrp lgmd1 lgmd1c lgmd1h lgmd2 lgmd2d lgmd2e lgmd2f lgmd2g lgmd2h lgmd2i lgmd2j lgmd2k lgmd2l lgmd2m lgmd2n lgmd2o lgmd2p lgmd2q lgmd2r lgmd2s lgmd2t lgmd2u lgmd2v lgmd2w pinch2 pomtng1 thity trappc11	aspects bio blotting cytoskeleton differentially dimensional downregulated downregulation electrophoresis eleven elucidate expressions gastric gastritis gel matched mucosa neuropolypeptide oxidation pebp1 phosphatidylethanolamine preliminarily rt ten thioredoxin upregulated upregulation validated varioliform
Tagcloud (Difference) ?		fkrp lgmd1 lgmd1c lgmd1h lgmd2 lgmd2d lgmd2e lgmd2f lgmd2g lgmd2h lgmd2i lgmd2j lgmd2k lgmd2l lgmd2m lgmd2n lgmd2o lgmd2p lgmd2q lgmd2r lgmd2s lgmd2t lgmd2u lgmd2v lgmd2w pinch2 pomtng1 thity trappc11	aspects bio blotting cytoskeleton differentially dimensional downregulated downregulation electrophoresis eleven elucidate expressions gastric gastritis gel matched mucosa neuropolypeptide oxidation pebp1 phosphatidylethanolamine preliminarily rt ten thioredoxin upregulated upregulation validated varioliform
Tagcloud (Intersection) ?