RUVBL2 and BCL3

Number of citations of the paper that reports this interaction (PMID 15829968)
56

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		RUVBL2	BCL3
Gene Name		RuvB-like AAA ATPase 2	B-cell CLL/lymphoma 3
Image
Gene Ontology Annotations	Cellular Component	Swr1 Complex Intracellular Nucleus Nucleoplasm Nuclear Euchromatin Cytoplasm Membrane Nuclear Matrix Ribonucleoprotein Complex Ino80 Complex NuA4 Histone Acetyltransferase Complex Extracellular Vesicular Exosome MLL1 Complex	Nucleus Nucleoplasm Cytoplasm Bcl3-Bcl10 Complex Bcl3/NF-kappaB2 Complex Protein Complex Intercellular Bridge Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding DNA Helicase Activity Damaged DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding ATPase Activity Chromatin DNA Binding Identical Protein Binding ATP-dependent 5'-3' DNA Helicase Activity Unfolded Protein Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Binding, Bridging
	Biological Process	DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Protein Folding DNA Duplex Unwinding Cellular Response To UV Positive Regulation Of Histone Acetylation Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Protein Localization To Chromatin Cellular Response To Estradiol Stimulus Transcriptional Activation By Promoter-enhancer Looping Negative Regulation Of Estrogen Receptor Binding	Protein Import Into Nucleus, Translocation Follicular Dendritic Cell Differentiation Marginal Zone B Cell Differentiation Humoral Immune Response Mediated By Circulating Immunoglobulin Germinal Center Formation Transcription, DNA-templated Cellular Response To DNA Damage Stimulus I-kappaB Kinase/NF-kappaB Signaling Response To Virus Response To UV-C Antimicrobial Humoral Response Extracellular Matrix Organization DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Interferon-gamma Production T-helper 1 Type Immune Response Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Defense Response To Bacterium Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Defense Response To Protozoan Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process T-helper 2 Cell Differentiation Positive Regulation Of Interleukin-10 Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Translation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Regulation Of DNA Binding Maintenance Of Protein Location In Nucleus
Pathways		Chromatin modifying enzymes Telomere Maintenance Chromosome Maintenance Chromatin organization Extension of Telomeres Telomere Extension By Telomerase HATs acetylate histones
Drugs
Diseases
GWAS			Alzheimer's disease (late onset) ( 23565137)
Protein-Protein Interactions		27 interactors: APP APPL1 APPL2 ATF2 BCL3 CCDC103 CDKN2A CTNNB1 DPCD EHMT2 EXOSC10 FBL FDFT1 HDAC1 HDAC4 LIG4 LNX1 MDM2 NDRG1 NUFIP1 PIH1D1 RUVBL1 STOM TAF9 TBP TERT YWHAQ	31 interactors: BARD1 COPS5 CREBBP CTBP1 CTBP2 CTNNB1 EP300 FOS FYN GSK3A GSK3B GTF2A1 GTF2B HDAC1 HDAC3 HDAC6 JUN KAT5 MAPK3 MAPRE1 N4BP2 NCOA1 NCOA6 NFKB1 NFKB2 PIR RAB9A RUVBL2 RXRA SHC1 TBP
Entrez ID		10856	602
HPRD ID		16070	00179
Ensembl ID		ENSG00000183207	ENSG00000069399
Uniprot IDs		B3KNL2 B3KQ59 Q9Y230	P20749
PDB IDs		2CQA 2XSZ 3UK6	1K1A 1K1B
Enriched GO Terms of Interacting Partners?		Chromatin Modification Positive Regulation Of Gene Expression Chromatin Organization Chromosome Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Histone Modification Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Cellular Component Assembly Peptidyl-lysine Modification Apoptotic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Cell Death Death Regulation Of Protein Sumoylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Apoptotic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Death Box C/D SnoRNP Assembly Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Biosynthetic Process Histone H3-K9 Modification Developmental Process Posttranscriptional Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Sexual Reproduction Ribonucleoprotein Complex Biogenesis Gene Expression Cellular Response To DNA Damage Stimulus Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Fungiform Papilla Formation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Chromatin Remodeling	Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Viral Process Response To Growth Factor Response To Organic Substance Cellular Response To Organic Substance Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Hormone Cellular Response To Hormone Stimulus Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway DNA-templated Transcription, Initiation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Histone Modification Cellular Response To Stress Fc Receptor Signaling Pathway Regulation Of Protein Metabolic Process
Tagcloud ?		ac accessible architecture attenuates baz1b clarify cytoprotective foci gammah2ax h2ax h3k56 h3k9 hubs integrated ints3 irradiation isoform mark matrix mount prevents proteomic respond runx runx2 scaffolding subnuclear supported	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Difference) ?		ac accessible architecture attenuates baz1b clarify cytoprotective foci gammah2ax h2ax h3k56 h3k9 hubs integrated ints3 irradiation isoform mark matrix mount prevents proteomic respond runx runx2 scaffolding subnuclear supported	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Intersection) ?