RUVBL2 and FDFT1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RUVBL2	FDFT1
Gene Name		RuvB-like AAA ATPase 2	farnesyl-diphosphate farnesyltransferase 1
Image
Gene Ontology Annotations	Cellular Component	Swr1 Complex Intracellular Nucleus Nucleoplasm Nuclear Euchromatin Cytoplasm Membrane Nuclear Matrix Ribonucleoprotein Complex Ino80 Complex NuA4 Histone Acetyltransferase Complex Extracellular Vesicular Exosome MLL1 Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding DNA Helicase Activity Damaged DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding ATPase Activity Chromatin DNA Binding Identical Protein Binding ATP-dependent 5'-3' DNA Helicase Activity Unfolded Protein Binding	Farnesyl-diphosphate Farnesyltransferase Activity Oxidoreductase Activity Squalene Synthase Activity
	Biological Process	DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Protein Folding DNA Duplex Unwinding Cellular Response To UV Positive Regulation Of Histone Acetylation Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Protein Localization To Chromatin Cellular Response To Estradiol Stimulus Transcriptional Activation By Promoter-enhancer Looping Negative Regulation Of Estrogen Receptor Binding	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Isoprenoid Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Farnesyl Diphosphate Metabolic Process Oxidation-reduction Process
Pathways		Chromatin modifying enzymes Telomere Maintenance Chromosome Maintenance Chromatin organization Extension of Telomeres Telomere Extension By Telomerase HATs acetylate histones	Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Cholesterol biosynthesis Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005)
Protein-Protein Interactions		27 interactors: APP APPL1 APPL2 ATF2 BCL3 CCDC103 CDKN2A CTNNB1 DPCD EHMT2 EXOSC10 FBL FDFT1 HDAC1 HDAC4 LIG4 LNX1 MDM2 NDRG1 NUFIP1 PIH1D1 RUVBL1 STOM TAF9 TBP TERT YWHAQ	6 interactors: ANXA5 ARL6IP1 FAM101A RUVBL2 SHPRH TMEM43
Entrez ID		10856	2222
HPRD ID		16070	01694
Ensembl ID		ENSG00000183207	ENSG00000079459
Uniprot IDs		B3KNL2 B3KQ59 Q9Y230	B4DT56 B4DWP0 B7Z1J3 P37268 Q6IAX1
PDB IDs		2CQA 2XSZ 3UK6	1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC
Enriched GO Terms of Interacting Partners?		Chromatin Modification Positive Regulation Of Gene Expression Chromatin Organization Chromosome Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Histone Modification Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Cellular Component Assembly Peptidyl-lysine Modification Apoptotic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Cell Death Death Regulation Of Protein Sumoylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Apoptotic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Death Box C/D SnoRNP Assembly Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Biosynthetic Process Histone H3-K9 Modification Developmental Process Posttranscriptional Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Sexual Reproduction Ribonucleoprotein Complex Biogenesis Gene Expression Cellular Response To DNA Damage Stimulus Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Fungiform Papilla Formation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Chromatin Remodeling	Negative Regulation Of Estrogen Receptor Binding Transcriptional Activation By Promoter-enhancer Looping Nuclear Membrane Organization Establishment Of Protein Localization To Chromatin DNA Conformation Change Negative Regulation Of Receptor Binding Protein Localization To Chromatin Histone H2A Acetylation
Tagcloud ?		ac accessible architecture attenuates baz1b clarify cytoprotective foci gammah2ax h2ax h3k56 h3k9 hubs integrated ints3 irradiation isoform mark matrix mount prevents proteomic respond runx runx2 scaffolding subnuclear supported	abca1 biosynthesis brains cassette cholesterol debated extensively fdps genetically idi1 ldr lipids microarray mvd mvk notably nsdhl oligomeric oligomers plaques principal qpcr sc4mol steroid steroids toxic unexpected unresolved verified
Tagcloud (Difference) ?		ac accessible architecture attenuates baz1b clarify cytoprotective foci gammah2ax h2ax h3k56 h3k9 hubs integrated ints3 irradiation isoform mark matrix mount prevents proteomic respond runx runx2 scaffolding subnuclear supported	abca1 biosynthesis brains cassette cholesterol debated extensively fdps genetically idi1 ldr lipids microarray mvd mvk notably nsdhl oligomeric oligomers plaques principal qpcr sc4mol steroid steroids toxic unexpected unresolved verified
Tagcloud (Intersection) ?