RUVBL2 and TERT

Number of citations of the paper that reports this interaction (PMID 18358808)
59

Data Source:
HPRD (in vivo)

		RUVBL2	TERT
Gene Name		RuvB-like AAA ATPase 2	telomerase reverse transcriptase
Image
Gene Ontology Annotations	Cellular Component	Swr1 Complex Intracellular Nucleus Nucleoplasm Nuclear Euchromatin Cytoplasm Membrane Nuclear Matrix Ribonucleoprotein Complex Ino80 Complex NuA4 Histone Acetyltransferase Complex Extracellular Vesicular Exosome MLL1 Complex	Telomerase Catalytic Core Complex Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Telomerase Holoenzyme Complex Nucleolus PML Body RNA-directed RNA Polymerase Complex Mitochondrial Nucleoid TERT-RMRP Complex
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding DNA Helicase Activity Damaged DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding ATPase Activity Chromatin DNA Binding Identical Protein Binding ATP-dependent 5'-3' DNA Helicase Activity Unfolded Protein Binding	TRNA Binding Transcription Coactivator Binding DNA Binding Telomerase Activity Telomeric Template RNA Reverse Transcriptase Activity RNA-directed RNA Polymerase Activity Protein Binding Nucleotidyltransferase Activity Telomeric DNA Binding Protein Homodimerization Activity Metal Ion Binding Telomeric RNA Binding
	Biological Process	DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Protein Folding DNA Duplex Unwinding Cellular Response To UV Positive Regulation Of Histone Acetylation Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Protein Localization To Chromatin Cellular Response To Estradiol Stimulus Transcriptional Activation By Promoter-enhancer Looping Negative Regulation Of Estrogen Receptor Binding	Telomere Maintenance Transcription, RNA-templated Age-dependent Telomere Shortening Telomere Maintenance Via Telomerase Mitochondrion Organization DNA Strand Elongation Positive Regulation Of Wnt Signaling Pathway Production Of SiRNA Involved In RNA Interference Telomere Formation Via Telomerase Replicative Senescence Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Chromatin modifying enzymes Telomere Maintenance Chromosome Maintenance Chromatin organization Extension of Telomeres Telomere Extension By Telomerase HATs acetylate histones	Telomere Maintenance Chromosome Maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex Extension of Telomeres Telomere Extension By Telomerase XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS			Bladder cancer ( 20972438) Breast cancer ( 22037553 23535729 23535733) Glioma ( 21827660 21531791 22886559 19578367) Idiopathic pulmonary fibrosis ( 18835860) Interstitial lung disease ( 23583980) Lung adenocarcinoma ( 20700438 19836008 22797724 20871597) Lung cancer ( 21725308 23143601 18978790) Melanoma ( 21983787) Prostate cancer ( 21743467) Prostate-specific antigen levels ( 21160077) Red blood cell count ( 20139978) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240)
Protein-Protein Interactions		27 interactors: APP APPL1 APPL2 ATF2 BCL3 CCDC103 CDKN2A CTNNB1 DPCD EHMT2 EXOSC10 FBL FDFT1 HDAC1 HDAC4 LIG4 LNX1 MDM2 NDRG1 NUFIP1 PIH1D1 RUVBL1 STOM TAF9 TBP TERT YWHAQ	51 interactors: ABL1 ACAA2 AKT1 ANXA2 ATP5B C19orf40 CCT5 CIB1 DDX51 DYNLL1 DYRK2 EIF2S1 ENO1 GLA HSP90AA1 HSPA4 IREB2 MCRS1 MDM2 MTOR NCL PABPC1 PBK PFDN1 PHF20L1 PINX1 PPIA PRKCA PTGES3 RELA RPS6KB1 RUVBL1 RUVBL2 SERBP1 SLC7A11 SMG5 SMG6 SRC STEAP4 TEP1 TERF1 TGFBR2 TIMM21 TPP1 TUBA1B U2SURP XPO1 XRCC5 XRCC6 YWHAQ YWHAZ
Entrez ID		10856	7015
HPRD ID		16070	01754
Ensembl ID		ENSG00000183207	ENSG00000164362
Uniprot IDs		B3KNL2 B3KQ59 Q9Y230	O14746
PDB IDs		2CQA 2XSZ 3UK6	2BCK 4B18
Enriched GO Terms of Interacting Partners?		Chromatin Modification Positive Regulation Of Gene Expression Chromatin Organization Chromosome Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Histone Modification Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Cellular Component Assembly Peptidyl-lysine Modification Apoptotic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Cell Death Death Regulation Of Protein Sumoylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Apoptotic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Death Box C/D SnoRNP Assembly Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Biosynthetic Process Histone H3-K9 Modification Developmental Process Posttranscriptional Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Sexual Reproduction Ribonucleoprotein Complex Biogenesis Gene Expression Cellular Response To DNA Damage Stimulus Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Fungiform Papilla Formation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Chromatin Remodeling	Organelle Organization Telomere Maintenance Cellular Response To Stress Response To Stress Response To Abiotic Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Intracellular Transport DNA Metabolic Process Mitotic Cell Cycle Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization RNA-dependent DNA Replication Regulation Of Cellular Localization Positive Regulation Of Protein Metabolic Process Cellular Metabolic Process Regulation Of Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Drug Regulation Of Protein Localization Regulation Of Cell Death Apoptotic Process Cell Cycle Response To Organic Substance Positive Regulation Of Organelle Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stimulus Mitotic Cell Cycle Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Peptidyl-amino Acid Modification Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Hypoxia ERBB Signaling Pathway Cellular Response To Decreased Oxygen Levels Negative Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Homeostatic Process Fc Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Oxygen Levels Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		ac accessible architecture attenuates baz1b clarify cytoprotective foci gammah2ax h2ax h3k56 h3k9 hubs integrated ints3 irradiation isoform mark matrix mount prevents proteomic respond runx runx2 scaffolding subnuclear supported	5alpha butyl chlorinated cholestane coprostanol dihydrocholesterol epicoprostanol ether experiment extraction fid final gc internal involves limit liquid methanol method microg namely quantification recovery reextraction saponification silylation solvents sterols urine
Tagcloud (Difference) ?		ac accessible architecture attenuates baz1b clarify cytoprotective foci gammah2ax h2ax h3k56 h3k9 hubs integrated ints3 irradiation isoform mark matrix mount prevents proteomic respond runx runx2 scaffolding subnuclear supported	5alpha butyl chlorinated cholestane coprostanol dihydrocholesterol epicoprostanol ether experiment extraction fid final gc internal involves limit liquid methanol method microg namely quantification recovery reextraction saponification silylation solvents sterols urine
Tagcloud (Intersection) ?