RUVBL2 and EHMT2

Number of citations of the paper that reports this interaction (PubMedID 20603076)
39

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		RUVBL2	EHMT2
Description		RuvB like AAA ATPase 2	euchromatic histone lysine methyltransferase 2
Image
GO Annotations	Cellular Component	Nucleosome Euchromatin Swr1 Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Membrane Nuclear Matrix Ino80 Complex NuA4 Histone Acetyltransferase Complex Ciliary Basal Body Extracellular Exosome MLL1 Complex R2TP Complex Protein Folding Chaperone Complex Dynein Axonemal Particle RPAP3/R2TP/prefoldin-like Complex Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Body Nuclear Speck
	Molecular Function	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding TFIID-class Transcription Factor Complex Binding DNA Helicase Activity Transcription Corepressor Activity Helicase Activity Protein Binding ATP Binding Beta-catenin Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity TBP-class Protein Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity ADP Binding Unfolded Protein Binding ATPase Binding Promoter-enhancer Loop Anchoring Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding P53 Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3K27 Methyltransferase Activity C2H2 Zinc Finger Domain Binding Histone H3K56 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Promoter-specific Chromatin Binding
	Biological Process	Box C/D SnoRNP Assembly Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Folding DNA Damage Response Regulation Of Chromosome Organization Cellular Response To UV Regulation Of Apoptotic Process Positive Regulation Of DNA Repair Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Protein Stabilization Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Establishment Of Protein Localization To Chromatin Cellular Response To Estradiol Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomere Maintenance In Response To DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Replication Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Synaptonemal Complex Assembly Spermatid Development Cellular Response To Starvation Fertilization Peptidyl-lysine Dimethylation Methylation Organ Growth Phenotypic Switching Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Behavioral Response To Cocaine Oocyte Development Neuron Fate Specification Cellular Response To Cocaine Negative Regulation Of Autophagosome Assembly
Pathways		Telomere Extension By Telomerase HATs acetylate histones	Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Methylation RNA Polymerase I Transcription Initiation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs		Quercetin
Diseases
GWAS			A body shape index ( 34021172) Anti-thyroid drug induced agranulocytosis ( 27157822) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Chronic hepatitis B infection ( 23760081 25802187) Chronotype ( 30696823) Clostridioides difficle infection ( 33841421) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Economic and political preferences (environmentalism) ( 22566634) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Femur bone mineral density x serum urate levels interaction ( 34046847) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Takayasu arteritis ( 25604533) Type 2 diabetes ( 29358691) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count ( 32888494)
Interacting Genes		34 interacting genes: AGR2 AKT1 APP APPL1 APPL2 ATF2 BCL3 CDKN2A CEBPA CTNNB1 DNAAF19 DNAJB4 DPCD EHMT2 EP300 EXOSC10 FBL FDFT1 HDAC1 HDAC4 LIG4 LNX1 MCPH1 MDM2 NDRG1 OGT RUVBL1 STOM TAF9 TBP TERT TXNIP UBR5 YWHAQ	63 interacting genes: ABHD17A ANKRD28 ATF7IP AURKA CACNA1A CCDC33 CHCHD2 CSNK2A1 CUX1 DNMT3A E4F1 EIF4A3 EIF4ENIF1 EPDR1 ESR1 ESS2 EXOSC7 FAM161A H1-1 H1-5 H3-3B H3-4 H3C1 H3C14 H3C15 HGS HIC2 ITGB5 KLF12 KLF6 LASP1 LIG1 LIMS1 LMO2 LNX1 MAZ MX2 NAA10 NAA11 NAPRT PLOD3 PRPF6 PRRC2B PSMA1 PTGER4 RD3 RELB RERE RPA1 RUVBL2 THAP7 TP53 UBASH3A VEZF1 WIZ XAGE2 ZBTB38 ZNF446 ZNF512B ZNF688 ZNF775 ZNF785 ZNF837
Entrez ID		10856	10919
HPRD ID		16070	06854
Ensembl ID		ENSG00000183207	ENSG00000204371
Uniprot IDs		B3KNL2 Q9Y230	A0A024RCN9 A2ABF8 A2ABF9 B7Z852 Q59FM7 Q96KQ7
PDB IDs		2CQA 2XSZ 3UK6 5OAF 6FO1 6H7X 6HTS 6IGM 6K0R 6QI8 6QI9 7AHO 7OLE 7P6X 7ZI4 8QR1 8X15 8X19 8X1C 8XVG 8XVT 9C57 9C62 9EMA 9EMC	2O8J 3DM1 3K5K 3RJW 4NVQ 5JHN 5JIN 5JIY 5JJ0 5T0K 5T0M 5TTF 5TUY 5V9I 5VSC 5VSE 6MM1 7BTV 7BUC 7DCF 7T7L 7X73 7XUA 7XUB 7XUC 7XUD 8VV8 8Z7C 8Z7D 8Z7E
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Protein-containing Complex Negative Regulation Of Transcription By RNA Polymerase II Protein Localization To Organelle DNA-binding Transcription Factor Binding Positive Regulation Of Gene Expression Response To Stress Protein Import Into Nucleus Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Gene Expression Import Into Nucleus Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process P53 Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Cellular Response To Stress Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Localization Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Developmental Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Metal Ion Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Nucleocytoplasmic Transport Nuclear Transport Regulation Of Cellular Localization Regulation Of Protein Localization To Nucleus Nucleus	Nucleus DNA Binding Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleosome Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Structural Constituent Of Chromatin Regulation Of DNA-templated Transcription Chromatin Organization Regulation Of RNA Biosynthetic Process Chromatin Remodeling Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleosome Assembly Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Zinc Ion Binding Regulation Of Primary Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein-DNA Complex Assembly Nucleosome Organization Protein Binding Euchromatin Metal Ion Binding Negative Regulation Of Transcription By RNA Polymerase II Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein N-terminal-serine Acetyltransferase Activity Chromosome Organization NatA Complex Chromatin Protein-N-terminal Amino-acid Acetyltransferase Activity Chromosome Protein Heterodimerization Activity Cellular Component Assembly RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleosomal DNA Binding Establishment Of Protein Localization To Chromatin Positive Regulation Of Biosynthetic Process TFIID-class Transcription Factor Complex Binding
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