GAD1 and HAAO

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
HPRD (two hybrid)

		GAD1	HAAO
Description		glutamate decarboxylase 1	3-hydroxyanthranilate 3,4-dioxygenase
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Cortex Vesicle Membrane Axon Axon Terminus Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Inhibitory Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse GABA-ergic Synapse	Cytoplasm Cytosol
	Molecular Function	Glutamate Decarboxylase Activity Protein Binding Lyase Activity Carbon-carbon Lyase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding Identical Protein Binding	3-hydroxyanthranilate 3,4-dioxygenase Activity Iron Ion Binding Protein Binding Ferrous Iron Binding Electron Transfer Activity Oxidoreductase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	L-glutamate Catabolic Process Gamma-aminobutyrate Shunt Chemical Synaptic Transmission Gamma-aminobutyric Acid Biosynthetic Process Carboxylic Acid Metabolic Process Social Behavior Locomotory Exploration Behavior	L-tryptophan Catabolic Process NAD+ Biosynthetic Process Response To Zinc Ion Pyridine Nucleotide Biosynthetic Process Quinolinate Biosynthetic Process 'de Novo' NAD+ Biosynthetic Process From L-tryptophan Anthranilate Metabolic Process Dicarboxylic Acid Metabolic Process Response To Cadmium Ion Quinolinate Metabolic Process Neuron Cellular Homeostasis
Pathways		GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling	Tryptophan catabolism
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glutamic acid
Diseases		Cerebral palsy
GWAS		Menopause (age at onset) ( 26414677)	Birth weight ( 31043758) Breastfeeding duration ( 25475840) Diastolic blood pressure ( 27841878) Glucose homeostasis traits ( 25524916) Hypospadias ( 25108383) Mean spheric corpuscular volume ( 32888494) Retinitis pigmentosa ( 33514863) Systolic blood pressure ( 27841878 28739976) White matter hyperintensity burden ( 25663218) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		18 interacting genes: AGTRAP BASP1 CALM1 CMTM5 GAD2 HAAO KRT31 KRT40 KRTAP3-2 MAL2 PPP2CA PPP2CB PRKACA PRKCE SNCA STK3 TRIM23 TRIP6	4 interacting genes: ARHGDIA GAD1 POT1 TERF2IP
Entrez ID		2571	23498
HPRD ID		12011	05158
Ensembl ID		ENSG00000128683	ENSG00000162882
Uniprot IDs		A0A0S2Z3V5 Q8IVA8 Q99259	P46952
PDB IDs		2OKJ 3VP6	2QNK 5TK5 5TKQ
Enriched GO Terms of Interacting Partners?		Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cytoskeleton Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Regulation Of Sequestering Of Calcium Ion Tau Protein Binding Regulation Of Calcium Ion Transmembrane Transport Response To Metal Ion Dopamine Biosynthetic Process Regulation Of Microtubule Polymerization Enzyme Activator Activity Cellular Response To Epinephrine Stimulus Regulation Of Calcium Ion Transport Vascular Endothelial Cell Response To Fluid Shear Stress Response To Epinephrine Synaptic Transmission, Dopaminergic Regulation Of Monoatomic Cation Transmembrane Transport Cytosol Keratin Filament Regulation Of Microtubule Polymerization Or Depolymerization FAR/SIN/STRIPAK Complex Negative Regulation Of Glycolytic Process Protein Phosphatase Type 2A Complex Response To Lead Ion Catecholamine Biosynthetic Process Regulation Of Monoatomic Ion Transmembrane Transport Ferrous Iron Binding Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Chemical Synaptic Transmission Negative Regulation Of ATP Metabolic Process Calcium Channel Complex Phosphate-containing Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Trans-synaptic Signaling Regulation Of Metal Ion Transport Synaptic Signaling Dopamine Metabolic Process Positive Regulation Of Synaptic Transmission Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cellular Response To Fluid Shear Stress Cell Communication Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Spindle Pole L-amino Acid Metabolic Process Intermediate Filament Biogenic Amine Biosynthetic Process Amine Biosynthetic Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Aromatic Amino Acid Metabolic Process Presynaptic Endocytosis	Nuclear Telomere Cap Complex Shelterin Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of DNA Strand Elongation Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Telomere Organization Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Negative Regulation Of DNA Metabolic Process Positive Regulation Of Telomeric Loop Disassembly Regulation Of Double-strand Break Repair Negative Regulation Of DNA Recombination At Telomere Rho GDP-dissociation Inhibitor Activity 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Chromosome, Telomeric Region Telomeric D-loop Binding Telomere Assembly Regulation Of DNA Repair Single-stranded Telomeric DNA Binding Regulation Of Chromosome Organization Gamma-aminobutyric Acid Biosynthetic Process Succinate Metabolic Process Telomerase Inhibitor Activity Positive Regulation Of DNA Metabolic Process Establishment Of Protein Localization To Telomere Protection From Non-homologous End Joining At Telomere L-glutamate Catabolic Process Gamma-aminobutyric Acid Metabolic Process Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane DEAD/H-box RNA Helicase Binding Carbon-carbon Lyase Activity Telomeric D-loop Disassembly Chromosome Organization Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Inhibitory Synapse
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