GAD1 and HAAO

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		GAD1	HAAO
Gene Name		glutamate decarboxylase 1 (brain, 67kDa)	3-hydroxyanthranilate 3,4-dioxygenase
Image
Gene Ontology Annotations	Cellular Component	Intracellular Plasma Membrane Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane	Cytosol Mitochondrial Membrane Extracellular Vesicular Exosome
	Molecular Function	Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein Heterodimerization Activity Protein N-terminus Binding	3-hydroxyanthranilate 3,4-dioxygenase Activity Ferrous Iron Binding Electron Carrier Activity Oxygen Binding
	Biological Process	Glutamate Catabolic Process Glutamate Decarboxylation To Succinate Synaptic Transmission Neurotransmitter Secretion Gamma-aminobutyric Acid Biosynthetic Process Protein-pyridoxal-5-phosphate Linkage Neurotransmitter Biosynthetic Process Response To Drug	Tryptophan Catabolic Process Response To Zinc Ion Quinolinate Biosynthetic Process 'de Novo' NAD Biosynthetic Process From Tryptophan Cellular Nitrogen Compound Metabolic Process Anthranilate Metabolic Process Small Molecule Metabolic Process Response To Cadmium Ion Oxidation-reduction Process Neuron Cellular Homeostasis
Pathways		Neurotransmitter Release Cycle GABA synthesis GABA synthesis, release, reuptake and degradation Transmission across Chemical Synapses	Tryptophan catabolism Metabolism of amino acids and derivatives
Drugs		Pyridoxal Phosphate L-Glutamic Acid
Diseases
GWAS
Protein-Protein Interactions		9 interactors: AGTRAP CMTM5 GAD2 HAAO PPP2CA PPP2CB PRKACA PRKCE STK3	4 interactors: ARHGDIA GAD1 POT1 TERF2IP
Entrez ID		2571	23498
HPRD ID		12011	05158
Ensembl ID		ENSG00000128683	ENSG00000162882
Uniprot IDs		Q8IVA8 Q99259	P46952
PDB IDs		2OKJ 3VP6	2QNK
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Peptidyl-tyrosine Phosphorylation Inactivation Of MAPK Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Activation Of Phospholipase C Activity Positive Regulation Of Phosphorylation Phosphate-containing Compound Metabolic Process Positive Regulation Of Phospholipase C Activity Regulation Of Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Catabolic Process Nuclear Envelope Organization Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Phospholipase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Cellular Glucuronidation Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Epithelial Cell Migration Negative Regulation Of MAP Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of MAPK Cascade Dicarboxylic Acid Metabolic Process Positive Regulation Of Protein Kinase Activity Response To Inorganic Substance Negative Regulation Of Signaling Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Glutamate Decarboxylation To Succinate TRAM-dependent Toll-like Receptor 4 Signaling Pathway Histone H3-T6 Phosphorylation Regulation Of Receptor Activity Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Cellular Amino Acid Catabolic Process Nucleus Organization Signaling Response To Hydrogen Peroxide	Telomere Capping Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Glutamate Decarboxylation To Succinate Protein-pyridoxal-5-phosphate Linkage Regulation Of Chromosome Organization Telomere Formation Via Telomerase Gamma-aminobutyric Acid Biosynthetic Process Protection From Non-homologous End Joining At Telomere DNA Replication Positive Regulation Of Helicase Activity Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Glutamate Catabolic Process Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Succinate Metabolic Process Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cellular Component Organization Gamma-aminobutyric Acid Metabolic Process Dicarboxylic Acid Catabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Telomerase Activity Neurotransmitter Biosynthetic Process Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Recombination Negative Regulation Of DNA Biosynthetic Process Glutamate Metabolic Process Regulation Of Double-strand Break Repair Neurotransmitter Metabolic Process Protein Localization To Chromosome Semaphorin-plexin Signaling Pathway Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Regulation Of Organelle Organization Rho Protein Signal Transduction Chromosome Organization Positive Regulation Of Hydrolase Activity Regulation Of DNA Repair
Tagcloud ?		ags aire autoimmune autoimmunity chrna1 copies ds dysregulation euploid fundamental graves hypothyroidism intrathymic klk3 owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically
Tagcloud (Difference) ?		ags aire autoimmune autoimmunity chrna1 copies ds dysregulation euploid fundamental graves hypothyroidism intrathymic klk3 owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically
Tagcloud (Intersection) ?