GAD1 and PPP2CA

Number of citations of the paper that reports this interaction (PMID 15147202)
7

Data Source:
HPRD (in vitro)

		GAD1	PPP2CA
Gene Name		glutamate decarboxylase 1 (brain, 67kDa)	protein phosphatase 2, catalytic subunit, alpha isozyme
Image
Gene Ontology Annotations	Cellular Component	Intracellular Plasma Membrane Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Mitochondrion Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Extracellular Vesicular Exosome
	Molecular Function	Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein Heterodimerization Activity Protein N-terminus Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Protein C-terminus Binding Metal Ion Binding Protein Dimerization Activity GABA Receptor Binding
	Biological Process	Glutamate Catabolic Process Glutamate Decarboxylation To Succinate Synaptic Transmission Neurotransmitter Secretion Gamma-aminobutyric Acid Biosynthetic Process Protein-pyridoxal-5-phosphate Linkage Neurotransmitter Biosynthetic Process Response To Drug	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Inactivation Of MAPK Activity Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Dephosphorylation Ceramide Metabolic Process Apoptotic Process Mitotic Nuclear Envelope Reassembly Mesoderm Development RNA Splicing Fibroblast Growth Factor Receptor Signaling Pathway Response To Organic Substance Gene Expression Regulation Of Receptor Activity Negative Regulation Of Epithelial To Mesenchymal Transition Second-messenger-mediated Signaling Regulation Of Wnt Signaling Pathway Regulation Of Cell Adhesion Negative Regulation Of Cell Growth Regulation Of Protein Autophosphorylation Regulation Of Growth Regulation Of Protein Catabolic Process Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cell Differentiation Meiotic Cell Cycle Protein Heterotrimerization Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Neurotransmitter Release Cycle GABA synthesis GABA synthesis, release, reuptake and degradation Transmission across Chemical Synapses	Signaling by GPCR Integration of energy metabolism Signaling by FGFR in disease Mitotic Prophase misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated ERKs are inactivated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Glycolysis Signaling by Wnt Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Degradation of beta-catenin by the destruction complex Toll Like Receptor 5 (TLR5) Cascade RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling G1/S Transition Glycogen storage diseases MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Beta-catenin phosphorylation cascade Initiation of Nuclear Envelope Reformation Mitotic G1-G1/S phases ERK/MAPK targets Negative regulation of FGFR signaling truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling Opioid Signalling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Spry regulation of FGF signaling Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Toll Like Receptor 2 (TLR2) Cascade Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Metabolism of carbohydrates Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System PP2A-mediated dephosphorylation of key metabolic factors MASTL Facilitates Mitotic Progression Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding Toll Like Receptor 7/8 (TLR7/8) Cascade G2/M Transition Mitotic Anaphase M Phase Toll Like Receptor TLR6:TLR2 Cascade APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated MyD88 cascade initiated on plasma membrane Cyclin A/B1 associated events during G2/M transition XAV939 inhibits tankyrase, stabilizing AXIN DARPP-32 events MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Nuclear Envelope Reassembly Innate Immune System Nonsense-Mediated Decay (NMD) E2F mediated regulation of DNA replication ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade CTLA4 inhibitory signaling G1 Phase NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Cell Cycle, Mitotic Signaling by FGFR Toll-Like Receptors Cascades Cyclin D associated events in G1 Toll Like Receptor 10 (TLR10) Cascade TCF dependent signaling in response to WNT ERK/MAPK targets deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling MAPK targets/ Nuclear events mediated by MAP kinases Signaling by WNT in cancer Inhibition of replication initiation of damaged DNA by RB1/E2F1 Nuclear Events (kinase and transcription factor activation)
Drugs		Pyridoxal Phosphate L-Glutamic Acid
Diseases
GWAS
Protein-Protein Interactions		9 interactors: AGTRAP CMTM5 GAD2 HAAO PPP2CA PPP2CB PRKACA PRKCE STK3	71 interactors: ADCY8 AKT1 APC AXIN1 BCL2 BEST1 BMPR1B CAD CAV1 CCNG1 CCNG2 CDK2 CDK6 CDKN2C CHEK2 CXCR2 DVL3 EEF2 EIF4EBP1 ETF1 FCAR GABRB3 GAD1 GOLGA2 HTT IGBP1 ISYNA1 JAK2 MAPK1 MAPK3 MAPT MID1 MRPS26 MYH9 NME2 NXN PACS1 PPP1CA PPP2R1A PPP2R1B PPP2R2A PPP2R3A PPP2R3B PPP2R5B PPP2R5C PPP2R5E PRKAA1 PRKCD PTN PXN RACGAP1 RBL2 RELA RHO RHOB RPS6KB1 RRAS SET SGK1 SGOL1 SGOL2 STAT5A STAT5B STRN TLX1 TP53 TRIP13 TSC2 VAC14 VDR XRN1
Entrez ID		2571	5515
HPRD ID		12011	08912
Ensembl ID		ENSG00000128683
Uniprot IDs		Q8IVA8 Q99259	B3KUN1 P67775
PDB IDs		2OKJ 3VP6	2IAE 2IE3 2IE4 2NPP 2NYL 2NYM 3C5W 3DW8 3FGA 3K7V 3K7W 3P71 4I5L 4I5N 4IYP
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Peptidyl-tyrosine Phosphorylation Inactivation Of MAPK Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Activation Of Phospholipase C Activity Positive Regulation Of Phosphorylation Phosphate-containing Compound Metabolic Process Positive Regulation Of Phospholipase C Activity Regulation Of Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Catabolic Process Nuclear Envelope Organization Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Phospholipase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Cellular Glucuronidation Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Epithelial Cell Migration Negative Regulation Of MAP Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of MAPK Cascade Dicarboxylic Acid Metabolic Process Positive Regulation Of Protein Kinase Activity Response To Inorganic Substance Negative Regulation Of Signaling Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Glutamate Decarboxylation To Succinate TRAM-dependent Toll-like Receptor 4 Signaling Pathway Histone H3-T6 Phosphorylation Regulation Of Receptor Activity Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Cellular Amino Acid Catabolic Process Nucleus Organization Signaling Response To Hydrogen Peroxide	Cell Cycle Mitotic Cell Cycle Regulation Of Catalytic Activity Cell Cycle Process Signal Transduction Cellular Response To Stimulus Regulation Of Protein Metabolic Process Signaling Cell Communication Regulation Of Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Proliferation Regulation Of Cell Death Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Regulation Of Phosphorylation Response To Organonitrogen Compound Regulation Of Phosphorus Metabolic Process Apoptotic Process Developmental Process Regulation Of Metabolic Process Response To Organic Substance Programmed Cell Death Mitotic Cell Cycle Process Regulation Of Kinase Activity Cellular Response To Organic Substance Anatomical Structure Development Cell Surface Receptor Signaling Pathway Cell Death Death Regulation Of Cellular Protein Metabolic Process System Development Cellular Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Apoptotic Process Regulation Of Body Fluid Levels Organ Development Multicellular Organismal Development Negative Regulation Of Programmed Cell Death Cellular Response To Peptide Response To Hormone Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Negative Regulation Of Cell Death Regulation Of Protein Kinase Activity Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Signal Transduction
Tagcloud ?		ags aire autoimmune autoimmunity chrna1 copies ds dysregulation euploid fundamental graves hypothyroidism intrathymic klk3 owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 rac3 rock2 thbs1 verify
Tagcloud (Difference) ?		ags aire autoimmune autoimmunity chrna1 copies ds dysregulation euploid fundamental graves hypothyroidism intrathymic klk3 owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 rac3 rock2 thbs1 verify
Tagcloud (Intersection) ?