GAD1

Gene Name		glutamate decarboxylase 1 (brain, 67kDa)
Image
Gene Ontology Annotations	Cellular Component	Intracellular Plasma Membrane Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
	Molecular Function	Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein Heterodimerization Activity Protein N-terminus Binding
	Biological Process	Glutamate Catabolic Process Glutamate Decarboxylation To Succinate Synaptic Transmission Neurotransmitter Secretion Gamma-aminobutyric Acid Biosynthetic Process Protein-pyridoxal-5-phosphate Linkage Neurotransmitter Biosynthetic Process Response To Drug
Pathways		Neurotransmitter Release Cycle GABA synthesis GABA synthesis, release, reuptake and degradation Transmission across Chemical Synapses
Drugs		Pyridoxal Phosphate L-Glutamic Acid
Diseases
GWAS
Protein-protein Interactions		9 interactors: AGTRAP CMTM5 GAD2 HAAO PPP2CA PPP2CB PRKACA PRKCE STK3
Entrez ID		2571
HPRD ID		12011
Ensembl ID		ENSG00000128683
Uniprot IDs		Q8IVA8 Q99259
PDB IDs		2OKJ 3VP6
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Peptidyl-tyrosine Phosphorylation Inactivation Of MAPK Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Activation Of Phospholipase C Activity Positive Regulation Of Phosphorylation Phosphate-containing Compound Metabolic Process Positive Regulation Of Phospholipase C Activity Regulation Of Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Catabolic Process Nuclear Envelope Organization Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Phospholipase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Cellular Glucuronidation Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Epithelial Cell Migration Negative Regulation Of MAP Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of MAPK Cascade Dicarboxylic Acid Metabolic Process Positive Regulation Of Protein Kinase Activity Response To Inorganic Substance Negative Regulation Of Signaling Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Glutamate Decarboxylation To Succinate TRAM-dependent Toll-like Receptor 4 Signaling Pathway Histone H3-T6 Phosphorylation Regulation Of Receptor Activity Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Cellular Amino Acid Catabolic Process Nucleus Organization Signaling Response To Hydrogen Peroxide
Tagcloud ?		ags aire autoimmune autoimmunity chrna1 copies ds dysregulation euploid fundamental graves hypothyroidism intrathymic klk3 owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically