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GAD1 and PPP2CB
Number of citations of the paper that reports this interaction (PMID
15147202
)
7
Data Source:
HPRD
(in vitro)
GAD1
PPP2CB
Gene Name
glutamate decarboxylase 1 (brain, 67kDa)
protein phosphatase 2, catalytic subunit, beta isozyme
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Intracellular
Plasma Membrane
Vesicle Membrane
Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Spindle Pole
Nucleus
Cytosol
Extracellular Vesicular Exosome
Molecular Function
Glutamate Decarboxylase Activity
Protein Binding
Glutamate Binding
Pyridoxal Phosphate Binding
Protein Heterodimerization Activity
Protein N-terminus Binding
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein C-terminus Binding
Metal Ion Binding
Biological Process
Glutamate Catabolic Process
Glutamate Decarboxylation To Succinate
Synaptic Transmission
Neurotransmitter Secretion
Gamma-aminobutyric Acid Biosynthetic Process
Protein-pyridoxal-5-phosphate Linkage
Neurotransmitter Biosynthetic Process
Response To Drug
Protein Dephosphorylation
Fibroblast Growth Factor Receptor Signaling Pathway
Apoptotic Mitochondrial Changes
Regulation Of Gene Expression
Response To Endoplasmic Reticulum Stress
Response To Hydrogen Peroxide
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Ras Protein Signal Transduction
Response To Antibiotic
Pathways
Neurotransmitter Release Cycle
GABA synthesis
GABA synthesis, release, reuptake and degradation
Transmission across Chemical Synapses
Signaling by GPCR
Integration of energy metabolism
Signaling by FGFR in disease
Mitotic Prophase
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
ERKs are inactivated
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Glycolysis
Signaling by Wnt
Glucose metabolism
Toll Like Receptor TLR1:TLR2 Cascade
Degradation of beta-catenin by the destruction complex
Toll Like Receptor 5 (TLR5) Cascade
RNF mutants show enhanced WNT signaling and proliferation
Myoclonic epilepsy of Lafora
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
G1/S Transition
Glycogen storage diseases
MyD88 dependent cascade initiated on endosome
Toll Like Receptor 9 (TLR9) Cascade
Beta-catenin phosphorylation cascade
Mitotic G1-G1/S phases
ERK/MAPK targets
Negative regulation of FGFR signaling
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TRIF-mediated TLR3/TLR4 signaling
Opioid Signalling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
Spry regulation of FGF signaling
Toll Like Receptor 2 (TLR2) Cascade
Platelet homeostasis
deletions in the AMER1 gene destabilize the destruction complex
Platelet sensitization by LDL
AMER1 mutants destabilize the destruction complex
Resolution of Sister Chromatid Cohesion
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Metabolism of carbohydrates
Mitotic G2-G2/M phases
Mitotic Metaphase and Anaphase
Adaptive Immune System
PP2A-mediated dephosphorylation of key metabolic factors
MASTL Facilitates Mitotic Progression
Mitotic Prometaphase
Costimulation by the CD28 family
Separation of Sister Chromatids
APC truncation mutants have impaired AXIN binding
Toll Like Receptor 7/8 (TLR7/8) Cascade
G2/M Transition
Mitotic Anaphase
Toll Like Receptor TLR6:TLR2 Cascade
M Phase
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
Activated TLR4 signalling
S37 mutants of beta-catenin aren't phosphorylated
MyD88 cascade initiated on plasma membrane
Cyclin A/B1 associated events during G2/M transition
XAV939 inhibits tankyrase, stabilizing AXIN
DARPP-32 events
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Innate Immune System
E2F mediated regulation of DNA replication
ERKs are inactivated
Signalling by NGF
MAP kinase activation in TLR cascade
CTLA4 inhibitory signaling
G1 Phase
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Cell Cycle, Mitotic
Signaling by FGFR
Toll-Like Receptors Cascades
Cyclin D associated events in G1
Toll Like Receptor 10 (TLR10) Cascade
TCF dependent signaling in response to WNT
ERK/MAPK targets
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
MAPK targets/ Nuclear events mediated by MAP kinases
Signaling by WNT in cancer
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Nuclear Events (kinase and transcription factor activation)
Drugs
Pyridoxal Phosphate
L-Glutamic Acid
Diseases
GWAS
Protein-Protein Interactions
9 interactors:
AGTRAP
CMTM5
GAD2
HAAO
PPP2CA
PPP2CB
PRKACA
PRKCE
STK3
26 interactors:
ACP5
AXIN1
C22orf39
DOCK7
GAD1
GSTA1
HK3
LCMT1
MAK
MAPT
MID1
PACS1
PLXNA3
PRKCB
RAF1
RELA
RPLP1
SGOL1
TAB1
TAB2
TCTEX1D2
TIPRL
TLX1
TRMT61B
ZFP28
ZNF775
Entrez ID
2571
5516
HPRD ID
12011
01487
Ensembl ID
ENSG00000128683
ENSG00000104695
Uniprot IDs
Q8IVA8
Q99259
P62714
PDB IDs
2OKJ
3VP6
Enriched GO Terms of Interacting Partners
?
Fibroblast Growth Factor Receptor Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of MAPK Cascade
Regulation Of Peptidyl-tyrosine Phosphorylation
Inactivation Of MAPK Activity
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Stimulus
Activation Of Phospholipase C Activity
Positive Regulation Of Phosphorylation
Phosphate-containing Compound Metabolic Process
Positive Regulation Of Phospholipase C Activity
Regulation Of Intracellular Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Catabolic Process
Nuclear Envelope Organization
Regulation Of Cellular Amino Acid Metabolic Process
Positive Regulation Of Phospholipase Activity
Positive Regulation Of Dense Core Granule Biogenesis
Positive Regulation Of Cellular Glucuronidation
Negative Regulation Of Intracellular Signal Transduction
Regulation Of Protein Phosphorylation
Positive Regulation Of Epithelial Cell Migration
Negative Regulation Of MAP Kinase Activity
Negative Regulation Of Signal Transduction
Regulation Of Phospholipase Activity
Positive Regulation Of Lipase Activity
Positive Regulation Of MAPK Cascade
Dicarboxylic Acid Metabolic Process
Positive Regulation Of Protein Kinase Activity
Response To Inorganic Substance
Negative Regulation Of Signaling
Positive Regulation Of Kinase Activity
Regulation Of Cellular Ketone Metabolic Process
Glutamate Decarboxylation To Succinate
TRAM-dependent Toll-like Receptor 4 Signaling Pathway
Histone H3-T6 Phosphorylation
Regulation Of Receptor Activity
Peptidyl-serine Phosphorylation
Regulation Of Phosphorylation
Cellular Amino Acid Catabolic Process
Nucleus Organization
Signaling
Response To Hydrogen Peroxide
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
Microtubule Cytoskeleton Organization
Positive Regulation Of MAPK Cascade
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
MAPK Cascade
Immune Response-regulating Signaling Pathway
JNK Cascade
Fc Receptor Signaling Pathway
Activation Of Protein Kinase Activity
Positive Regulation Of Phosphorylation
Regulation Of Peptidyl-serine Phosphorylation
Signal Transduction By Phosphorylation
Positive Regulation Of Signal Transduction
Toll-like Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of MAPK Cascade
Pattern Recognition Receptor Signaling Pathway
Organ Development
Innate Immune Response-activating Signal Transduction
Anatomical Structure Morphogenesis
Antigen Receptor-mediated Signaling Pathway
Regulation Of Metabolic Process
Activation Of MAPK Activity
Activation Of Innate Immune Response
Regulation Of Phosphorus Metabolic Process
Generation Of Neurons
Positive Regulation Of Protein Phosphorylation
Negative Regulation Of Insulin Receptor Signaling Pathway
Neuron Differentiation
Cytoskeleton Organization
Tagcloud
?
ags
aire
autoimmune
autoimmunity
chrna1
copies
ds
dysregulation
euploid
fundamental
graves
hypothyroidism
intrathymic
klk3
owing
pge
plp1
predisposition
promiscuous
restricted
sag
strikingly
thymus
thymuses
thyroglobulin
thyroiditis
tolerance
trisomy
typically
Tagcloud (Difference)
?
ags
aire
autoimmune
autoimmunity
chrna1
copies
ds
dysregulation
euploid
fundamental
graves
hypothyroidism
intrathymic
klk3
owing
pge
plp1
predisposition
promiscuous
restricted
sag
strikingly
thymus
thymuses
thyroglobulin
thyroiditis
tolerance
trisomy
typically
Tagcloud (Intersection)
?