OXR1 and KEAP1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		OXR1	KEAP1
Gene Name		oxidation resistance 1	kelch-like ECH-associated protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleolus Mitochondrion	Nucleoplasm Cytoplasm Endoplasmic Reticulum Microtubule Organizing Center Cytosol Midbody Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Molecular_function Oxidoreductase Activity	Protein Binding Transcription Factor Binding
	Biological Process	Response To Oxidative Stress Adult Walking Behavior Negative Regulation Of Neuron Apoptotic Process Oxidation-reduction Process Cellular Response To Hydroperoxide	In Utero Embryonic Development Transcription, DNA-templated Proteasomal Ubiquitin-independent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: KEAP1 LIG4	38 interactors: AK4 AMER1 ATG5 BAD BPTF CAT CCNB1IP1 CLU DPP3 ETF1 FAM117B FAM46A GLRX5 GYPA IPO11 IRF1 KLHL3 KPNA6 LSM3 MAD2L1 MAPKBP1 MYO7A NFE2L2 NUDT4 OXR1 PDCD6IP PIDD1 PRKAG1 PRKCE PTMA RECK RELA SNRPN SQSTM1 TERF1 TSC22D4 WDR83 ZSCAN32
Entrez ID		55074	9817
HPRD ID		16126	12079
Ensembl ID		ENSG00000164830	ENSG00000079999
Uniprot IDs		Q8N573	Q14145
PDB IDs			1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4IN4 4IQK
Enriched GO Terms of Interacting Partners?		DNA Ligation Involved In DNA Recombination Proteasomal Ubiquitin-independent Protein Catabolic Process Lagging Strand Elongation Pro-B Cell Differentiation In Utero Embryonic Development Establishment Of Integrated Proviral Latency Establishment Of Viral Latency Immunoglobulin V(D)J Recombination DNA Ligation Involved In DNA Repair T Cell Receptor V(D)J Recombination Lymphoid Progenitor Cell Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Cellular Response To Lithium Ion Single Strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Isotype Switching Embryo Development V(D)J Recombination DNA Strand Elongation Involved In DNA Replication Response To Lithium Ion DNA Strand Elongation Response To X-ray Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Cellular Response To Interleukin-4 Regulation Of Epidermal Cell Differentiation Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Response To Interleukin-4 B Cell Activation Involved In Immune Response Response To Gamma Radiation Regulation Of Cell Differentiation Neuron Apoptotic Process Immunoglobulin Production Regulation Of Epidermis Development Positive Regulation Of Fibroblast Proliferation Neuron Death Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process T Cell Differentiation In Thymus Somatic Stem Cell Maintenance Positive Regulation Of Proteasomal Protein Catabolic Process Nucleotide-excision Repair Regulation Of Fibroblast Proliferation DNA-dependent DNA Replication DNA Biosynthetic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Metal Ion Regulation Of Epithelial Cell Differentiation See more	Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Virus Positive Regulation Of Interleukin-12 Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Cellular Response To Nicotine Apoptotic Process Response To Other Organism Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Programmed Cell Death Response To Biotic Stimulus Cell Death Death Regulation Of Interleukin-12 Biosynthetic Process ADP Metabolic Process Response To Reactive Oxygen Species Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Mucus Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Response To Oxidative Stress Regulation Of Mucus Secretion Regulation Of Proteolysis Negative Regulation Of Cell Cycle Regulation Of Cell Division Regulation Of Type I Interferon Production Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Response To Hydrogen Peroxide Response To Drug Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Macrophage Activation Metabolic Process Regulation Of Wound Healing See more
Tagcloud ?		30mg 6j binge caloric consumption dampened dark drinking eating episodes evaluates foods intraperitoneal lh libitum locomotor orexin overconsumption palatable preferred reinforced reinforcing repetitive saccharin sb seeking substances sucrose	acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg
Tagcloud (Difference) ?		30mg 6j binge caloric consumption dampened dark drinking eating episodes evaluates foods intraperitoneal lh libitum locomotor orexin overconsumption palatable preferred reinforced reinforcing repetitive saccharin sb seeking substances sucrose	acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg
Tagcloud (Intersection) ?