PITX1 and SLC15A2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PITX1	SLC15A2
Name		paired like homeodomain 1	solute carrier family 15 member 2
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Plasma Membrane Membrane Apical Plasma Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Symporter Activity Peptide:proton Symporter Activity Transmembrane Transporter Activity Oligopeptide Transmembrane Transporter Activity Tripeptide Transmembrane Transporter Activity Dipeptide Transmembrane Transporter Activity
	Biological Process	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Branchiomeric Skeletal Muscle Development Pituitary Gland Development Embryonic Hindlimb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Myoblast Fate Commitment Cartilage Development	Immune System Process Oligopeptide Transport Protein Transport Peptide Transport Peptidoglycan Transport Xenobiotic Transport Dipeptide Transport Innate Immune Response Transmembrane Transport Renal Absorption Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Dipeptide Import Across Plasma Membrane Tripeptide Import Across Plasma Membrane Antibacterial Innate Immune Response Transport Across Blood-brain Barrier Proton Transmembrane Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Drugs		None	Ampicillin Cefotaxime Oxacillin Benzylpenicillin
Diseases		Congenital clubfoot; Congenital talipes equinovarus	None
GWAS		Appendicular lean mass ( 33097823 ) Atrial fibrillation ( 29237688 ) Bulimia nervosa ( 23568457 ) Colorectal cancer ( 23263487 30529582 24836286 ) Colorectal cancer or advanced adenoma ( 30510241 ) DHEAS levels ( 34748635 ) Height ( 25429064 31562340 18391951 23563607 20881960 ) Hip circumference adjusted for BMI ( 34021172 ) Immune response to anthrax vaccine ( 22658931 ) Testicular germ cell tumor ( 28604732 23666240 )	Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708 ) Glomerular filtration rate ( 29403010 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) Multiple sclerosis ( 21833088 ) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 )
Interacting Genes		98 interacting genes: - ABHD11 ACTMAP AKAP8L ALG13 ANKRD10 ARID5A ATN1 BPIFA1 C10orf55 C1orf94 C9orf57 CDX4 CEACAM6 CFAP68 CYSRT1 DCTN3 DVL3 DZIP3 EFEMP2 EGR1 FAM168A FAM168B FOXO1 GATA1 GOLGA2 HGS HOXA1 HSF4 HYI IGFL2 IPO13 KLHL26 KRT34 KRT83 KRTAP13-1 KRTAP13-2 KRTAP19-5 KRTAP19-7 KRTAP26-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LZTS2 MAGED1 METTL27 MGAT5B MSX2 MYH7B MYOZ3 NEUROD1 NHLRC4 NID2 NR5A1 PFDN5 PLA2G10 PLEKHB2 PLSCR1 PLSCR3 POU1F1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 PTK6 RBPMS RFX6 RHOXF2 RNF31 ROR2 SERGEF SERPINE1 SLC15A2 SMARCA2 SPAG8 STH TBX19 TBX22 TEKT5 TFAP2D TLE5 TP53BP1 TRAF1 TRAPPC2 TRIM23 TSC1 UFSP1 UPF2 VGLL3 YPEL3 ZBTB32 ZNF34	26 interacting genes: ADAM12 ANKS1A AQP1 C11orf87 CHRD ENKD1 KLHL38 KPRP KRT34 KRTAP12-2 KRTAP12-3 KRTAP15-1 KRTAP26-1 KRTAP6-3 LMO4 NHERF4 NTAQ1 OTX1 PDZK1 PITX1 PLSCR4 SMARCC1 TENT5B TLX3 VENTX WWOX
Entrez ID		5307	6565
HPRD ID		03688	09088
Ensembl ID		ENSG00000069011	ENSG00000163406
Uniprot IDs		P78337 X5D9A5	Q16348
PDB IDs		Not available	6EZI 7PMY
GO Terms Enriched among Interactors		Intermediate Filament Chromatin Protein Binding Keratin Filament DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Lead Ion Binding Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mercury Ion Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Transcription By RNA Polymerase II Axonemal A Tubule Inner Sheath Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Structural Molecule Activity	Intermediate Filament Brush Border