PITX1 and ARID5A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PITX1	ARID5A
Description		paired like homeodomain 1	AT-rich interaction domain 5A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Transcription Corepressor Activity RNA Binding Protein Binding Transcription Factor Binding Nuclear Estrogen Receptor Binding RNA Stem-loop Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding Sequence-specific DNA Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding Nuclear Androgen Receptor Binding
	Biological Process	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Branchiomeric Skeletal Muscle Development Pituitary Gland Development Embryonic Hindlimb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Myoblast Fate Commitment Cartilage Development	Negative Regulation Of Transcription By RNA Polymerase II Chondrocyte Differentiation Immune System Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Cellular Response To Estrogen Stimulus Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 1 Cell Cytokine Production
Pathways
Drugs
Diseases		Congenital clubfoot; Congenital talipes equinovarus
GWAS		Appendicular lean mass ( 33097823) Atrial fibrillation ( 29237688) Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487 30529582 24836286) Colorectal cancer or advanced adenoma ( 30510241) DHEAS levels ( 34748635) Height ( 25429064 31562340 18391951 23563607 20881960) Hip circumference adjusted for BMI ( 34021172) Immune response to anthrax vaccine ( 22658931) Testicular germ cell tumor ( 28604732 23666240)	Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 27863252 32888494) Event-related brain oscillations ( 21184583)
Interacting Genes		98 interacting genes: - ABHD11 ACTMAP AKAP8L ALG13 ANKRD10 ARID5A ATN1 BPIFA1 C10orf55 C1orf94 C9orf57 CDX4 CEACAM6 CFAP68 CYSRT1 DCTN3 DVL3 DZIP3 EFEMP2 EGR1 FAM168A FAM168B FOXO1 GATA1 GOLGA2 HGS HOXA1 HSF4 HYI IGFL2 IPO13 KLHL26 KRT34 KRT83 KRTAP13-1 KRTAP13-2 KRTAP19-5 KRTAP19-7 KRTAP26-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LZTS2 MAGED1 METTL27 MGAT5B MSX2 MYH7B MYOZ3 NEUROD1 NHLRC4 NID2 NR5A1 PFDN5 PLA2G10 PLEKHB2 PLSCR1 PLSCR3 POU1F1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 PTK6 RBPMS RFX6 RHOXF2 RNF31 ROR2 SERGEF SERPINE1 SLC15A2 SMARCA2 SPAG8 STH TBX19 TBX22 TEKT5 TFAP2D TLE5 TP53BP1 TRAF1 TRAPPC2 TRIM23 TSC1 UFSP1 UPF2 VGLL3 YPEL3 ZBTB32 ZNF34	127 interacting genes: ACTMAP ANKRD11 AR ATP6V0D2 ATXN1 ATXN1L BAG4 BAHD1 BANP BOLL C14orf119 CAMK2A CATSPER1 CCDC120 CCDC57 CKS1B COX5B CRYBA1 CRYBA2 CYSRT1 DAB1 DAZAP2 DOK6 DTX2 ESR2 ESRP1 FAM168B FHL3 FOXD2 FOXH1 GATA5 GLIS2 GOLGA2 GRB2 HDAC7 HOXA1 HSD3B7 INIP IRX6 KAZN KCTD9 KDF1 KRT40 KRTAP10-8 KRTAP12-2 KRTAP12-4 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP22-1 KRTAP26-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LENG8 LIMS3 LIMS4 LITAF LMO2 MAB21L2 MAGED1 MDFI MIEN1 MKRN3 MORN3 MYLIP NUDT22 ODAM OLIG3 OTX1 PHF1 PIBF1 PIN1 PITX1 PLA2G10 PLAGL2 PLEKHN1 PNMA1 POU1F1 PRDM6 PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E QRICH1 RARA RBFOX1 RBPMS RBPMS2 RFC5 RHOXF2 RNF44 ROR2 RXRA SEC24A SH2D2A SMYD1 SOHLH1 SOX5 TEKT3 TEKT4 TENT5A TENT5D TGM7 THRA TNS2 TRAF1 TRIM27 TRIM73 TSC1 TSEN15 TSSK3 UBTD2 USP20 VAC14 VENTX ZC3H10 ZIC1 ZNF503 ZNF765
Entrez ID		5307	10865
HPRD ID		03688	12481
Ensembl ID		ENSG00000069011	ENSG00000196843
Uniprot IDs		P78337 X5D9A5	Q03989
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Chromatin Protein Binding Keratin Filament DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Lead Ion Binding Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mercury Ion Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Transcription By RNA Polymerase II Axonemal A Tubule Inner Sheath Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Structural Molecule Activity	Intermediate Filament Protein Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding Identical Protein Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Nuclear Receptor-mediated Signaling Pathway Sequence-specific Double-stranded DNA Binding Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Sequence-specific DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Spinal Cord Motor Neuron Migration POZ Domain Binding Regulation Of Gene Expression Chromatin Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Nuclear Steroid Receptor Activity Retinoic Acid Receptor Signaling Pathway Regulation Of Metabolic Process Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of MRNA Metabolic Process Zinc Ion Binding Nucleus Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System
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