PITX1 and NEUROD1

Number of citations of the paper that reports this interaction (PMID 9343431)
36

Data Source:
HPRD (in vitro)

		PITX1	NEUROD1
Gene Name		paired-like homeodomain 1	neuronal differentiation 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Nucleolus Cytoplasm	Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Skeletal System Development Transcription, DNA-templated Anatomical Structure Morphogenesis Branchiomeric Skeletal Muscle Development Pituitary Gland Development Embryonic Hindlimb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Myoblast Fate Commitment Cartilage Development	Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Transcription, DNA-templated Nucleocytoplasmic Transport Nitric Oxide Mediated Signal Transduction Response To Glucose Anterior/posterior Pattern Specification Dentate Gyrus Development Cerebellum Development Neurogenesis Signal Transduction Involved In Regulation Of Gene Expression Insulin Secretion Endocrine Pancreas Development Amacrine Cell Differentiation Enteroendocrine Cell Differentiation Response To Drug Glucose Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JAK-STAT Cascade Embryonic Organ Morphogenesis Inner Ear Development Regulation Of Insulin Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Intestinal Epithelial Structure Maintenance Regulation Of Cell Cycle Arrest Cellular Response To Glucose Stimulus Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways			Regulation of beta-cell development Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells Regulation of gene expression in beta cells
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Height ( 20881960 23563607 18391951) Immune response to anthrax vaccine ( 22658931) Testicular germ cell tumor ( 23666240)
Protein-Protein Interactions		24 interactors: ALG13 C1orf94 CDX4 DVL3 EGR1 HGS IPO13 LZTS2 MAGED1 MGAT5B NEUROD1 NR5A1 PLSCR1 POU1F1 PRR20A RBPMS RFX6 RHOXF2 RNF31 SMARCA2 SPAG8 TRIM23 UPF2 ZBTB32	12 interactors: CALM1 CALM2 CALM3 DUSP3 EP300 HAP1 MAFA MAP3K10 PDX1 PITX1 RREB1 TCF4
Entrez ID		5307	4760
HPRD ID		03688	03428
Ensembl ID		ENSG00000069011	ENSG00000162992
Uniprot IDs		P78337	Q13562
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nuclear Transport Regulation Of Metabolic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Pancreatic A Cell Differentiation Macromolecule Biosynthetic Process Regulation Of Signaling RNA Metabolic Process Regulation Of Signal Transduction Gene Expression Nucleocytoplasmic Transport Organ Development Negative Regulation Of JAK-STAT Cascade Enteroendocrine Cell Differentiation Negative Regulation Of Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Cytoplasmic Transport Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process System Development Positive Regulation Of Kidney Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Aging Negative Regulation Of Wnt Signaling Pathway Glandular Epithelial Cell Differentiation Negative Regulation Of Gene Expression Pancreatic Epsilon Cell Differentiation Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Pancreatic D Cell Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cation Channel Activity Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Cellular Biosynthetic Process Second-messenger-mediated Signaling Positive Regulation Of Metabolic Process Glucose Metabolic Process Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Glycogen Metabolic Process Intracellular Signal Transduction Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Hexose Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Cation Channel Activity Positive Regulation Of Ion Transmembrane Transport Neurotrophin Signaling Pathway Polysaccharide Metabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Secretion By Cell Positive Regulation Of Nitric-oxide Synthase Activity Cell Surface Receptor Signaling Pathway Monosaccharide Metabolic Process Regulation Of Cell Cycle Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Glycogen Catabolic Process Positive Regulation Of Calcium Ion Transport Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Central Nervous System Development Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Response To Stress Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Organic Substance
Tagcloud ?		17beta 3x0 3x20 antide buserelin diarylpropionitrile dpn egr1 erb esr1 esr2 gnrh gnrhr gonadotroph lhb microinjected microinjections oestradiol oestrogenic orchestrated ovariectomised pituitaries ppt propyl pulsatile pulses pyrazole stimulations triol	aa ad1 ad2 beta2 carboxy cbp chimeras coactivator constructs convert creb ectoderm ectopic embryos evolutionarily gal4 helix implicate islet morphogenesis precursors premature separable spanning transactivation utilized xenopus
Tagcloud (Difference) ?		17beta 3x0 3x20 antide buserelin diarylpropionitrile dpn egr1 erb esr1 esr2 gnrh gnrhr gonadotroph lhb microinjected microinjections oestradiol oestrogenic orchestrated ovariectomised pituitaries ppt propyl pulsatile pulses pyrazole stimulations triol	aa ad1 ad2 beta2 carboxy cbp chimeras coactivator constructs convert creb ectoderm ectopic embryos evolutionarily gal4 helix implicate islet morphogenesis precursors premature separable spanning transactivation utilized xenopus
Tagcloud (Intersection) ?