PITX1 and ZNF34

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PITX1	ZNF34
Description		paired like homeodomain 1	zinc finger protein 34
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Branchiomeric Skeletal Muscle Development Pituitary Gland Development Embryonic Hindlimb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Myoblast Fate Commitment Cartilage Development	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways			Generic Transcription Pathway
Drugs
Diseases		Congenital clubfoot; Congenital talipes equinovarus
GWAS		Appendicular lean mass ( 33097823) Atrial fibrillation ( 29237688) Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487 30529582 24836286) Colorectal cancer or advanced adenoma ( 30510241) DHEAS levels ( 34748635) Height ( 25429064 31562340 18391951 23563607 20881960) Hip circumference adjusted for BMI ( 34021172) Immune response to anthrax vaccine ( 22658931) Testicular germ cell tumor ( 28604732 23666240)	Blood metabolite levels ( 26401656) Logical memory (immediate recall) in normal cognition ( 29274321) Type 2 diabetes ( 30054458)
Interacting Genes		98 interacting genes: - ABHD11 ACTMAP AKAP8L ALG13 ANKRD10 ARID5A ATN1 BPIFA1 C10orf55 C1orf94 C9orf57 CDX4 CEACAM6 CFAP68 CYSRT1 DCTN3 DVL3 DZIP3 EFEMP2 EGR1 FAM168A FAM168B FOXO1 GATA1 GOLGA2 HGS HOXA1 HSF4 HYI IGFL2 IPO13 KLHL26 KRT34 KRT83 KRTAP13-1 KRTAP13-2 KRTAP19-5 KRTAP19-7 KRTAP26-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LZTS2 MAGED1 METTL27 MGAT5B MSX2 MYH7B MYOZ3 NEUROD1 NHLRC4 NID2 NR5A1 PFDN5 PLA2G10 PLEKHB2 PLSCR1 PLSCR3 POU1F1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 PTK6 RBPMS RFX6 RHOXF2 RNF31 ROR2 SERGEF SERPINE1 SLC15A2 SMARCA2 SPAG8 STH TBX19 TBX22 TEKT5 TFAP2D TLE5 TP53BP1 TRAF1 TRAPPC2 TRIM23 TSC1 UFSP1 UPF2 VGLL3 YPEL3 ZBTB32 ZNF34	44 interacting genes: ANKHD1 CYSRT1 DAZAP2 DTX2 FOXH1 GCM2 HGS HOXC8 KRTAP10-5 KRTAP26-1 KRTAP8-1 LENG8 LMO2 MAPKBP1 MKRN3 NFYC OTX1 PITX1 PITX2 PLSCR4 POU6F2 RBPMS RBPMS2 ROR2 RSPH1 RUSC1 SPAG8 TBX3 TBX6 TCF7L2 TFG TIAM1 TLE5 TLX3 TRIP13 UBAP2 VAC14 VENTX VGLL3 VPS37C WDR25 YTHDF1 ZC3H10 ZIC1
Entrez ID		5307	80778
HPRD ID		03688	11772
Ensembl ID		ENSG00000069011	ENSG00000196378
Uniprot IDs		P78337 X5D9A5	A0A0C4DG42 E9PNZ6 Q8IZ26
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Chromatin Protein Binding Keratin Filament DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Lead Ion Binding Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mercury Ion Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Transcription By RNA Polymerase II Axonemal A Tubule Inner Sheath Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Structural Molecule Activity	DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleus Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Myoblast Fate Commitment Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Embryonic Hindlimb Morphogenesis Pattern Specification Process Embryonic Morphogenesis Hindlimb Morphogenesis Cytoplasmic Stress Granule Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Inner Ear Morphogenesis DNA Binding Outflow Tract Morphogenesis Wnt Signaling Pathway Regionalization Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Metabolic Process Negative Regulation Of Androgen Receptor Signaling Pathway Embryonic Digestive Tract Morphogenesis Axis Specification Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Identical Protein Binding Cell Fate Specification Positive Regulation Of Metabolic Process Embryonic Limb Morphogenesis
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