PITX1 and POU1F1

Number of citations of the paper that reports this interaction (PubMedID 8755540)
45

Data Source:
BioGRID (two hybrid, pull down)
HPRD (two hybrid, in vitro)

		PITX1	POU1F1
Description		paired like homeodomain 1	POU class 1 homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding LncRNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Branchiomeric Skeletal Muscle Development Pituitary Gland Development Embryonic Hindlimb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Myoblast Fate Commitment Cartilage Development	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Adenohypophysis Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases		Congenital clubfoot; Congenital talipes equinovarus	Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Appendicular lean mass ( 33097823) Atrial fibrillation ( 29237688) Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487 30529582 24836286) Colorectal cancer or advanced adenoma ( 30510241) DHEAS levels ( 34748635) Height ( 25429064 31562340 18391951 23563607 20881960) Hip circumference adjusted for BMI ( 34021172) Immune response to anthrax vaccine ( 22658931) Testicular germ cell tumor ( 28604732 23666240)	Menarche (age at onset) ( 25231870) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		98 interacting genes: - ABHD11 ACTMAP AKAP8L ALG13 ANKRD10 ARID5A ATN1 BPIFA1 C10orf55 C1orf94 C9orf57 CDX4 CEACAM6 CFAP68 CYSRT1 DCTN3 DVL3 DZIP3 EFEMP2 EGR1 FAM168A FAM168B FOXO1 GATA1 GOLGA2 HGS HOXA1 HSF4 HYI IGFL2 IPO13 KLHL26 KRT34 KRT83 KRTAP13-1 KRTAP13-2 KRTAP19-5 KRTAP19-7 KRTAP26-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LZTS2 MAGED1 METTL27 MGAT5B MSX2 MYH7B MYOZ3 NEUROD1 NHLRC4 NID2 NR5A1 PFDN5 PLA2G10 PLEKHB2 PLSCR1 PLSCR3 POU1F1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 PTK6 RBPMS RFX6 RHOXF2 RNF31 ROR2 SERGEF SERPINE1 SLC15A2 SMARCA2 SPAG8 STH TBX19 TBX22 TEKT5 TFAP2D TLE5 TP53BP1 TRAF1 TRAPPC2 TRIM23 TSC1 UFSP1 UPF2 VGLL3 YPEL3 ZBTB32 ZNF34	22 interacting genes: ARID5A ARSA CREBBP ETS1 GATA2 JUN KRTAP10-8 KRTAP15-1 KRTAP6-1 LASP1 LHX4 MSX2 NCOR1 NR1I2 NR1I3 NR3C1 PITX1 PPARA PPARG RAD54L2 UBE2I VDR
Entrez ID		5307	5449
HPRD ID		03688	01409
Ensembl ID		ENSG00000069011	ENSG00000064835
Uniprot IDs		P78337 X5D9A5	P28069
PDB IDs			5WC9
Enriched GO Terms of Interacting Partners?		Intermediate Filament Chromatin Protein Binding Keratin Filament DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Lead Ion Binding Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mercury Ion Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Transcription By RNA Polymerase II Axonemal A Tubule Inner Sheath Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Structural Molecule Activity	Sequence-specific DNA Binding Regulation Of MiRNA Transcription Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nuclear Receptor Activity Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Regulation Of DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of MiRNA Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Transcription Regulator Complex Positive Regulation Of MiRNA Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Nuclear Retinoid X Receptor Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of MiRNA Transcription Cell Differentiation Nuclear Receptor-mediated Signaling Pathway Cellular Developmental Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
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