PITX1 and POU1F1

Number of citations of the paper that reports this interaction (PMID 8755540)
29

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vitro, two hybrid)

		PITX1	POU1F1
Gene Name		paired-like homeodomain 1	POU class 1 homeobox 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Nucleolus Cytoplasm	Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity
	Biological Process	Skeletal System Development Transcription, DNA-templated Anatomical Structure Morphogenesis Branchiomeric Skeletal Muscle Development Pituitary Gland Development Embryonic Hindlimb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Myoblast Fate Commitment Cartilage Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Fate Specification Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Determination Of Adult Lifespan B Cell Differentiation Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Positive Regulation Of Multicellular Organism Growth Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Nuclear Transport Somatotropin Secreting Cell Development
Pathways
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Height ( 20881960 23563607 18391951) Immune response to anthrax vaccine ( 22658931) Testicular germ cell tumor ( 23666240)
Protein-Protein Interactions		24 interactors: ALG13 C1orf94 CDX4 DVL3 EGR1 HGS IPO13 LZTS2 MAGED1 MGAT5B NEUROD1 NR5A1 PLSCR1 POU1F1 PRR20A RBPMS RFX6 RHOXF2 RNF31 SMARCA2 SPAG8 TRIM23 UPF2 ZBTB32	12 interactors: CREBBP ETS1 GATA2 JUN NCOR1 NR1I2 NR1I3 NR3C1 PITX1 PPARA PPARG VDR
Entrez ID		5307	5449
HPRD ID		03688	01409
Ensembl ID		ENSG00000069011	ENSG00000064835
Uniprot IDs		P78337	P28069
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nuclear Transport Regulation Of Metabolic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Pancreatic A Cell Differentiation Macromolecule Biosynthetic Process Regulation Of Signaling RNA Metabolic Process Regulation Of Signal Transduction Gene Expression Nucleocytoplasmic Transport Organ Development Negative Regulation Of JAK-STAT Cascade Enteroendocrine Cell Differentiation Negative Regulation Of Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Cytoplasmic Transport Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process System Development Positive Regulation Of Kidney Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Aging Negative Regulation Of Wnt Signaling Pathway Glandular Epithelial Cell Differentiation Negative Regulation Of Gene Expression Pancreatic Epsilon Cell Differentiation Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Pancreatic D Cell Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway	Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway RNA Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Cellular Response To Steroid Hormone Stimulus Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Intracellular Receptor Signaling Pathway Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Steroid Hormone Negative Regulation Of Gene Expression Response To Lipid Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Response To Organic Cyclic Compound Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Gland Development Diencephalon Development Response To Hormone Cellular Response To Hormone Stimulus Response To Organic Substance
Tagcloud ?		17beta 3x0 3x20 antide buserelin diarylpropionitrile dpn egr1 erb esr1 esr2 gnrh gnrhr gonadotroph lhb microinjected microinjections oestradiol oestrogenic orchestrated ovariectomised pituitaries ppt propyl pulsatile pulses pyrazole stimulations triol	ago architectural architecture artificial bypassing developmentally enhancer enhancers exemplified homeodomain matrin naturally occupied otherwise pit1 r271w ref requisite rescued restores satb1 serves subnuclear tethered tethering unanticipated unexpectedly untethered
Tagcloud (Difference) ?		17beta 3x0 3x20 antide buserelin diarylpropionitrile dpn egr1 erb esr1 esr2 gnrh gnrhr gonadotroph lhb microinjected microinjections oestradiol oestrogenic orchestrated ovariectomised pituitaries ppt propyl pulsatile pulses pyrazole stimulations triol	ago architectural architecture artificial bypassing developmentally enhancer enhancers exemplified homeodomain matrin naturally occupied otherwise pit1 r271w ref requisite rescued restores satb1 serves subnuclear tethered tethering unanticipated unexpectedly untethered
Tagcloud (Intersection) ?