PITX1 and CFAP68

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PITX1	CFAP68
Description		paired like homeodomain 1	cilia and flagella associated protein 68
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Branchiomeric Skeletal Muscle Development Pituitary Gland Development Embryonic Hindlimb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Myoblast Fate Commitment Cartilage Development	Flagellated Sperm Motility
Pathways
Drugs
Diseases		Congenital clubfoot; Congenital talipes equinovarus
GWAS		Appendicular lean mass ( 33097823) Atrial fibrillation ( 29237688) Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487 30529582 24836286) Colorectal cancer or advanced adenoma ( 30510241) DHEAS levels ( 34748635) Height ( 25429064 31562340 18391951 23563607 20881960) Hip circumference adjusted for BMI ( 34021172) Immune response to anthrax vaccine ( 22658931) Testicular germ cell tumor ( 28604732 23666240)
Interacting Genes		98 interacting genes: - ABHD11 ACTMAP AKAP8L ALG13 ANKRD10 ARID5A ATN1 BPIFA1 C10orf55 C1orf94 C9orf57 CDX4 CEACAM6 CFAP68 CYSRT1 DCTN3 DVL3 DZIP3 EFEMP2 EGR1 FAM168A FAM168B FOXO1 GATA1 GOLGA2 HGS HOXA1 HSF4 HYI IGFL2 IPO13 KLHL26 KRT34 KRT83 KRTAP13-1 KRTAP13-2 KRTAP19-5 KRTAP19-7 KRTAP26-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LZTS2 MAGED1 METTL27 MGAT5B MSX2 MYH7B MYOZ3 NEUROD1 NHLRC4 NID2 NR5A1 PFDN5 PLA2G10 PLEKHB2 PLSCR1 PLSCR3 POU1F1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 PTK6 RBPMS RFX6 RHOXF2 RNF31 ROR2 SERGEF SERPINE1 SLC15A2 SMARCA2 SPAG8 STH TBX19 TBX22 TEKT5 TFAP2D TLE5 TP53BP1 TRAF1 TRAPPC2 TRIM23 TSC1 UFSP1 UPF2 VGLL3 YPEL3 ZBTB32 ZNF34	35 interacting genes: AGXT ANKRD11 ARMC7 ATG9A ATPAF2 CATSPER1 CNOT2 COL8A1 DMRT3 DTX2 FOXH1 FRS3 HGS HOXA1 HOXC8 HR KANK2 KLHL38 KRTAP13-2 MGAT5B MYO15B OTX1 PATZ1 PEF1 PITX1 PLSCR4 PRKAB2 PROP1 PRR35 SETDB1 SMYD1 TEKT4 TLE5 TLX3 ZIC1
Entrez ID		5307	64776
HPRD ID		03688	12601
Ensembl ID		ENSG00000069011	ENSG00000137720
Uniprot IDs		P78337 X5D9A5	E9PS93 Q9H5F2
PDB IDs			7UNG 8J07
Enriched GO Terms of Interacting Partners?		Intermediate Filament Chromatin Protein Binding Keratin Filament DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Lead Ion Binding Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mercury Ion Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Transcription By RNA Polymerase II Axonemal A Tubule Inner Sheath Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Structural Molecule Activity	Sequence-specific Double-stranded DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Anatomical Structure Morphogenesis Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Phospholipid Scramblase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Plasma Membrane Phospholipid Scrambling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Pattern Specification Process
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