PITX1 and IPO13

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid, two hybrid)

		PITX1	IPO13
Description		paired like homeodomain 1	importin 13
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Small GTPase Binding
	Biological Process	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Branchiomeric Skeletal Muscle Development Pituitary Gland Development Embryonic Hindlimb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Myoblast Fate Commitment Cartilage Development	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport
Pathways
Drugs
Diseases		Congenital clubfoot; Congenital talipes equinovarus
GWAS		Appendicular lean mass ( 33097823) Atrial fibrillation ( 29237688) Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487 30529582 24836286) Colorectal cancer or advanced adenoma ( 30510241) DHEAS levels ( 34748635) Height ( 25429064 31562340 18391951 23563607 20881960) Hip circumference adjusted for BMI ( 34021172) Immune response to anthrax vaccine ( 22658931) Testicular germ cell tumor ( 28604732 23666240)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		98 interacting genes: - ABHD11 ACTMAP AKAP8L ALG13 ANKRD10 ARID5A ATN1 BPIFA1 C10orf55 C1orf94 C9orf57 CDX4 CEACAM6 CFAP68 CYSRT1 DCTN3 DVL3 DZIP3 EFEMP2 EGR1 FAM168A FAM168B FOXO1 GATA1 GOLGA2 HGS HOXA1 HSF4 HYI IGFL2 IPO13 KLHL26 KRT34 KRT83 KRTAP13-1 KRTAP13-2 KRTAP19-5 KRTAP19-7 KRTAP26-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LZTS2 MAGED1 METTL27 MGAT5B MSX2 MYH7B MYOZ3 NEUROD1 NHLRC4 NID2 NR5A1 PFDN5 PLA2G10 PLEKHB2 PLSCR1 PLSCR3 POU1F1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 PTK6 RBPMS RFX6 RHOXF2 RNF31 ROR2 SERGEF SERPINE1 SLC15A2 SMARCA2 SPAG8 STH TBX19 TBX22 TEKT5 TFAP2D TLE5 TP53BP1 TRAF1 TRAPPC2 TRIM23 TSC1 UFSP1 UPF2 VGLL3 YPEL3 ZBTB32 ZNF34	20 interacting genes: ALX1 ARX CRX EIF1AX GK HMBOX1 MAGOH NOSIP NPSR1 NUP50 PAX3 PAX6 PBX4 PITX1 PSMA1 RAN RBM8A RNF10 RPL5 UBE2I
Entrez ID		5307	9670
HPRD ID		03688	13742
Ensembl ID		ENSG00000069011	ENSG00000117408
Uniprot IDs		P78337 X5D9A5	O94829
PDB IDs			2X19 2XWU 3ZJY
Enriched GO Terms of Interacting Partners?		Intermediate Filament Chromatin Protein Binding Keratin Filament DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Lead Ion Binding Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mercury Ion Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Transcription By RNA Polymerase II Axonemal A Tubule Inner Sheath Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Structural Molecule Activity	Translation Initiation Factor Activity Chromatin Translational Initiation Exon-exon Junction Subcomplex Mago-y14 Cytosol Sequence-specific Double-stranded DNA Binding Nuclear Export Nuclear Transport Nucleocytoplasmic Transport RNA Transport RNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Neuron Development Translation Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex RNA Export From Nucleus Nuclear Pore Nucleobase-containing Compound Transport Translation Factor Activity, RNA Binding Exon-exon Junction Complex Cell Development Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Nucleoplasm Pronuclear Fusion Regulation Of Macromolecule Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Chromatin Binding Cytoplasm Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process MRNA Transport Sequence-specific DNA Binding Forebrain-midbrain Boundary Formation Pituitary Gland Development Pancreatic A Cell Development SUMO Conjugating Enzyme Activity Structural Constituent Of Presynapse Cytoplasmic Translational Initiation
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